找到约 35 条 “HA-100” 相关结果 （用时 0.098 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M5260
|
Hydroxyfasudil hydrochloride | 羟基法舒地尔盐酸盐 | ROCK |
| HA-1100 HCl | |||
| Hydroxyfasudil(HA-1100)是fasudil hydrochloride的活性代谢物，是特异性的Rho-kinase(ROCK)抑制剂，对ROCK1和ROCK2的IC50分别为0.73 μM和0.72 μM。 | |||
| M6552
|
HA-100 | HA-100 | PKA |
| C-1 | |||
| HA-100 是一种有效的蛋白激酶抑制剂，抑制 PKG，PKA，PKC 和 MLC 激酶的 IC50 值分别为 4 μM、8 μM、12 μM 和 240 μM。HA-100 也用作 ROCK 抑制剂。 | |||
| M12163 | ChemBridge-5569100 | ChemBridge化合物-5569100 | Screening Compounds and Building Blocks |
| 1-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(3-ethyl-2-imino-2,3-dihydro-1H-benzimidazol-1-yl)ethanone hydrochloride (5569100) | |||
| ChemBridge特有类药化合物/先导化合物-5569100，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M13728 | Hydroxyfasudil | 羟基法舒地尔 | ROCK |
| HA-1100 | |||
| Hydroxyfasudil 是一种 ROCK 抑制剂，可抑制 ROCK1 和 ROCK2 的活性，IC50 值分别为 0.73 和 0.72 μM。 | |||
M19989
|
Insulin-Transferrin-Selenium-Ethanolamine (ITS-X) (100X) | 胰岛素-转铁蛋白-硒-氨基乙醇 (ITS-X) (100X) | Cell Culture |
| Insulin-Transferrin-Selenium-Ethanolamine (ITS-X) （胰岛素-转铁蛋白-硒-氨基乙醇 (ITS-X) (100X)）是胰岛素、转铁蛋白、亚硒酸钠和氨基乙醇的混合物。它是一种基础细胞培养基(Basal cell culture media)的补充剂。在多种细胞培养过程中可显著降低胎牛血清(FBS)的用量，常用于无血清或低血清细胞培养系统。 | |||
| M20755 | HA-100 dihydrochloride | HA-100 dihydrochloride | PKC |
| HA-100 dihydrochloride is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase with IC50 of 4 μM, 8 μM, 12 μM and 240 μM, respectively. | |||
| M21586
|
Poly(2-hydroxyethyl methacrylate) (MW 1000000) | 聚甲基丙烯酸羟乙酯 (MW 1000000) | Others |
| Poly(2-hydroxyethyl methacrylate) (MW 1000000) 是生物材料领域最重要的水凝胶之一。Poly(2-hydroxyethyl methacrylate) 是隐形眼镜的基本成分，还用于软组织的植入，腕骨和骨的合成移植，神经系统组织的再生，化合物的传递等。 | |||
| M42037 | HA-1004 | HA-1004 | PKA |
| HA-1004 是一种 PKA 的选择性抑制剂，能抑制脂肪分解，诱导血管松弛。 | |||
| M48449 | ChemBridge-57510076 | ChemBridge化合物-57510076 | Screening Compounds and Building Blocks |
| (3,4-dimethoxyphenyl)[1-(2-hydroxyethyl)-3-piperidinyl]methanone (57510076) | |||
| ChemBridge特有类药化合物/先导化合物-57510076，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M49172 | ChemBridge-91852100 | ChemBridge化合物-91852100 | Screening Compounds and Building Blocks |
| [4-(2,3-dichlorobenzyl)-1-methylpiperazin-2-yl]methanol (91852100) | |||
| ChemBridge特有类药化合物/先导化合物-91852100，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M50103 | ChemBridge-88410074 | ChemBridge化合物-88410074 | Screening Compounds and Building Blocks |
| 2-(3-{[(5-phenyl-6,7-dihydro-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino]methyl}piperidin-1-yl)ethanol (88410074) | |||
| ChemBridge特有类药化合物/先导化合物-88410074，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M2210
|
A-803467 | A-803467 | Sodium Channel |
| A803467 | |||
| A-803467是一种选择性NaV1.8 channel抑制剂，IC50为8 nM，抑制抗河豚毒的电流，比作用于人类NaV1.2， NaV1.3， NaV1.5和NaV1.7选择性高100倍以上。 | |||
| M2264
|
Oxcarbazepine | 奥卡西平 | Sodium Channel |
| Trileptal | |||
| Oxcarbazepine是一种抗惊厥的化合物。抑制[3H]BTX与sodium channels结合， IC50位160 μM，也抑制22Na+汇入大鼠脑i突触体， IC50约为100 μM。 | |||
| M2322
|
PHA-767491 | PHA-767491 | CDK |
| CAY10572 | |||
| PHA-767491是一种有效的，ATP竞争性的，双重Cdc7/CDK9抑制剂，IC50分别为10 nM和34 nM，比作用于CDK1/2和GSK3-β选择性高20倍左右，比作用于MK2和CDK5选择性高50倍，比作用于PLK1和CHK2选择性高100倍。 | |||
| M2380
|
Ambroxol hydrochloride | 盐酸氨溴索 | Sodium Channel |
| Ambroxol HCl是有效的神经性钠离子通道（Sodium Channel）抑制剂，抑制抗TTX的钠离子电流，相位性阻滞，IC50为22.5 μM，抑制对TTX敏感的钠离子电流，IC50为100 μM。 | |||
| M4014
|
Licochalcone-C | 甘草查尔酮C | Glucosidase |
| Lico-C | |||
| Licochalcone C 能够抑制 α-葡萄糖苷酶 (α-glucosidase)，其对 α-葡萄糖苷酶和蛋白酪氨酸磷酸酶 1B 的 IC50 值分别为 <100 nM 和 92.43 μM。Licochalcone-C是一种脂多糖-干扰素-γ炎症的抑制剂。 | |||
| M5076
|
ZK200775 hydrate | ZK200775 hydrate | GluR |
| Fanapanel; MPQX | |||
| ZK200775 hydrate is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. | |||
| M6998 | MRS 1334 | MRS 1334 | Adenosine Receptor |
| MRS 1334是一种对人腺苷A3受体具有强效和高选择性的拮抗剂。在hA3处Ki值为2.69 nM，在A1和A2A处>值为100 μM。 | |||
| M7177
|
Quinine hydrochloride | 金鸡纳碱单盐酸盐 | Potassium Channel |
| Quinine hydrochloride（金鸡纳碱单盐酸盐）是一种从金鸡纳树皮中提取的生物碱Quinine的盐酸盐形式，具有抗疟和抗肿瘤活性，作用于恶性疟原虫passou和3CD7株的IC50值分别是60 ng/mL和107.8 ng/mL。同时，Quinine hydrochloride 也是一种钾离子通道 (potassium channel) 抑制剂，可抑制电压脉冲引起的 MT mSlo3 (KCa5.1) 通道 +100 mV 电流, 其 IC50 值为 169 μM。此外，Quinine hydrochloride还能以低纳摩尔亲和力与嘌呤核苷磷酸化酶（PfPNP）结合。 | |||
| M8124 | Quinine hemisulfate salt monohydrate | 奎宁半硫酸盐一水合物 | Potassium Channel |
| Quinine hemisulfate salt monohydrate是一种钾离子通道 (potassium channel) 抑制剂，可抑制电压脉冲引起的 MT mSlo3 (KCa5.1) 通道 +100 mV 电流, 其 IC50 值为 169 μM。此外，Quinine hemisulfate salt monohydrate还能以低纳摩尔亲和力与嘌呤核苷磷酸化酶（PfPNP）结合。 | |||
| M8686
|
CCF642 | CCF642 | Apoptosis |
| CCF642 is a cell-permeable protein disulfide isomerase (PDI) inhibitor that exhibits 100-fold higher potency than PACMA 31 (by di-E-GSSG assay) via an alternative mode of action that most likely involves PDI active-site CGHCK motifs. | |||
| M8700 | PCS1055 dihydrochloride | PCS1055 dihydrochloride | Others |
| PCS1055 is a potent and selective muscarinic M4 acetylcholine receptor competitive antagonist that exhibits >100-fold selectivity over M1-, M3-, and M5-receptors and 30-fold selectivity at the M2 receptor. | |||
| M8705 | J104129 fumarate | J104129 fumarate | Others |
| J104129 is a muscarinic M3 receptor antagonist greater than 100-fold selectivity for M3 over M2 receptors. | |||
| M10822
|
GNE-781 | GNE-781 | Epigenetic Reader Domain |
| GNE-781 (compound 19) 是一种高效的、口服活性的、选择性的 bromodomain 抑制剂对cyclic adenosine monophosphate response element binding protein (CBP) 的IC50值为0.94 nM (in TR-FRET assay)。GNE-781 还抑制 BRET 和 BRD4(1)，IC50分别为6.2 nM和5100 nM。 GNE-781 具有抗肿瘤活性。 | |||
| M40683
|
Recombinant Human RBP4 (HEK293, C-His) | 重组人RBP4 (HEK293, C-His) | Cytokines and Growth Factors |
| Retinol-Binding Protein 4 | |||
| Human-retinol binding protein is a single-chain polypeptide with a molecular weight of approximately 21000 and one binding site for retinol and other forms of vitamin A. In plasma, RBP4-retinol forms a complex with transthyretin (TTR), also known as thyroxine-binding protein and prealbumin. Defects in RBP4 cause retinol-binding protein deficiency, which affects night vision. | |||
| M19429
|
Quinine | 奎宁 | Parasite |
| Quinine 是一种钾离子通道 (potassium channel) 抑制剂，可抑制电压脉冲引起的 MT mSlo3 (KCa5.1) 通道 +100 mV 电流, 其 IC50 值为 169 μM。此外，Quinine还能以低纳摩尔亲和力与嘌呤核苷磷酸化酶（PfPNP）结合。 | |||
| M20597 | PF-562271 HCl | PF-562271 HCl | FAK |
| PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1. | |||
| M21203
|
Recombinant Human/Mouse/Rat Irisin (HEK293, C-6His) | 重组人/小鼠/大鼠Irisin蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
| Fibronectin type III domain-containing protein 5 | |||
| Fibronectin type III domain-containing protein 5 is the precursor of irisin. Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts. | |||
| M21204
|
Recombinant Human/Mouse/Rat Irisin (HEK293, C-Fc) | 重组人/小鼠/大鼠Irisin蛋白 (HEK293, C-Fc) | Cytokines and Growth Factors |
| Fibronectin type III domain-containing protein 5 | |||
| Fibronectin type III domain-containing protein 5 is the precursor of irisin. Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts. | |||
| M21205
|
Recombinant Human/Mouse/Rat Irisin (HEK293, N-6His) | 重组人/小鼠/大鼠Irisin 蛋白(HEK293, N-6His) | Cytokines and Growth Factors |
| Fibronectin type III domain-containing protein 5 | |||
| Fibronectin type III domain-containing protein 5 is the precursor of irisin. Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts. | |||
| M29225 | PROTAC Sirt2 Degrader-1 | PROTAC Sirt2 Degrader-1 | Sirtuin |
| PROTAC Sirt2 Degrader-1 是一种基于 SirReal 的 PROTAC，为 Sirt2 的降解剂，由一个高效、同种型选择性的 Sirt2 抑制剂，一个连接物和 thalidomide (Cereblon E3 泛素化连接酶的配体) 组成。PROTAC Sirt2 Degrader-1 对 Sirt2 的 IC50 值为 0.25 μM，而对 Sirt1/Sirt3 (IC50>100 μM) 无作用。 | |||
| M30635
|
Quinine hemisulfate | 奎宁半硫酸盐 | Potassium Channel |
| Quinine hemisulfate 是一种从金鸡纳树皮中提取的生物碱，具有口服活性，可用作抗疟疾研究。Quinine hemisulfate 是一种钾离子通道 (potassium channel) 抑制剂，可抑制电压脉冲引起的 MT mSlo3 (KCa5.1) 通道 +100 mV 电流, 其 IC50 值为 169 μM。此外，Quinine hemisulfate还能以低纳摩尔亲和力与嘌呤核苷磷酸化酶（PfPNP）结合。 | |||
| M30967 | TTA-A2 | TTA-A2 | Calcium Channel |
| TTA-A2 是一种强效、选择性和口服活性的 T 型电压门控钙通道 (calcium channel) 拮抗剂，可减少孕烷 X 受体 (PXR) 的激活。TTA-A2 对 Cav3.1 (a1G) 和 Cav3.2 (a1H) 通道在 -80 mV 和- 100 mV 保持电位上具有同样的作用，IC50 值分别为 89 nM 和 92 nM。TTA-A2 可用于多种人类神经系统疾病的研究，包括睡眠障碍和癫痫。 | |||
| M31124
|
Quinine dihydrochloride | 奎宁二盐酸盐 | Parasite |
| Quinine 2HCl | |||
| Quinine dihydrochloride 是一种从金鸡纳树皮中提取的生物碱，具有口服活性。Quinine dihydrochloride 也是一种钾离子通道 (potassium channel) 抑制剂，可抑制电压脉冲引起的 MT mSlo3 (KCa5.1) 通道 +100 mV 电流, 其 IC50 值为 169 μM。此外，Quinine dihydrochloride还能以低纳摩尔亲和力与嘌呤核苷磷酸化酶（PfPNP）结合。 | |||
| M41127 | Quinine sulfate hydrate | Quinine sulfate hydrate | Potassium Channel |
| Quinine sulfate hydrate (2:1:4)是一种具有口服活性钾离子通道 (potassium channel) 抑制剂，可抑制电压脉冲引起的 MT mSlo3 (KCa5.1) 通道 +100 mV 电流, 其 IC50 值为 169 μM。此外，Quinine sulfate hydrate还能以低纳摩尔亲和力与嘌呤核苷磷酸化酶（PfPNP）结合。 | |||
