找到约 37 条 “Dehydrogenase” 相关结果 （用时 0.104 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M25491
|
Malic Dehydrogenase | 苹果酸脱氢酶 (来源于微生物) | Enzymes & Coenzymes |
| 苹果酸脱氢酶（MDH）在线粒体的柠檬酸循环中起重要作用。它催化底物苹果酸盐和草酰乙酸的相互转化，同时催化NAD/NADH+的氧化/还原。 | |||
| M31174
|
Alcohol dehydrogenase | 乙醇脱氢酶 | Dehydrogenase |
| ADH; EC 1.1.1.1 | |||
| Alcohol dehydrogenase（乙醇脱氢酶）是一种细胞内存在的二聚蛋白，能催化羰基可逆还原成相应的醇。 | |||
| M31314
|
D-Lactate dehydrogenase | D-乳酸脱氢酶 | Dehydrogenase |
| D-LDH; EC 1.1.1.28 | |||
| D-Lactate dehydrogenase(乳酸脱氢酶)是一种广泛存在于细菌和真菌中的氧化还原酶，能以 NAD+或 NADP+ 为受体，作用于供体 CH-OH 基团，同时还可以催化 D-乳酸氧化生成丙酮酸。 | |||
| M50320 | Mannitol dehydrogenase | Mannitol dehydrogenase | Enzymes & Coenzymes |
| Mannitol dehydrogenase 是一种生化试剂，可作为生物材料或有机化合物，用于生命科学相关研究。 | |||
| M50327 | myo-Inositol dehydrogenase | myo-Inositol dehydrogenase | Enzymes & Coenzymes |
| myo-Inositol dehydrogenase 是一种生化试剂，可作为生物材料或有机化合物，用于生命科学相关研究。 | |||
| M50329 | Phenylalanine dehydrogenase | Phenylalanine dehydrogenase | Enzymes & Coenzymes |
| Phenylalanine dehydrogenase 是一种生化试剂，可作为生物材料或有机化合物，用于生命科学相关研究。 | |||
| M50333 | α-Ketoglutarate dehydrogenase | α-Ketoglutarate dehydrogenase | Enzymes & Coenzymes |
| α-Ketoglutarate dehydrogenase 是一种生化试剂，可作为生物材料或有机化合物，用于生命科学相关研究。 | |||
| M50335 | Glutamate dehydrogenase (NADP) | Glutamate dehydrogenase (NADP) | Enzymes & Coenzymes |
| Glutamate dehydrogenase (NADP) 是一种生化试剂，可作为生物材料或有机化合物，用于生命科学相关研究。 | |||
| M50343 | Fructose 5-dehydrogenase (acceptor) | Fructose 5-dehydrogenase (acceptor) | Enzymes & Coenzymes |
| Fructose 5-dehydrogenase (acceptor) (D-Fructose dehydrogenase) 是一种生化试剂，可作为生物材料或有机化合物，用于生命科学相关研究。 | |||
| M50348 | (R)-Alcohol dehydrogenase | (R)-Alcohol dehydrogenase | Enzymes & Coenzymes |
| (R)-Alcohol dehydrogenase (E.C. 1.1.1.2) 是一种生化试剂，可作为生物材料或有机化合物，用于生命科学相关研究。 | |||
| M50349 | Malate dehydrogenase oxaloacetate-decarboxylating, NADP+ | Malate dehydrogenase oxaloacetate-decarboxylating, NADP+ | Enzymes & Coenzymes |
| Malate dehydrogenase (oxaloacetate-decarboxylating, NADP+) 是一种生化试剂，可作为生物材料或有机化合物，用于生命科学相关研究。 | |||
| M50351 | Phosphogluconate dehydrogenase (NADP, decarboxylating) | Phosphogluconate dehydrogenase (NADP, decarboxylating) | Enzymes & Coenzymes |
| Phosphogluconate dehydrogenase (NADP, decarboxylating) (6-Phosphogluconate dehydrogenase) 是一种生化试剂，可作为生物材料或有机化合物，用于生命科学相关研究。 | |||
| M52599 | Glycerol dehydrogenase | Glycerol dehydrogenase | Metabolite/Endogenous Metabolite |
| Glycerol dehydrogenase 是一种多元醇脱氢酶，可催化 NAD 依赖性的甘油氧化成二羟基丙酮。 | |||
| M52607 | beta-Galactose dehydrogenase | beta-Galactose dehydrogenase | Metabolite/Endogenous Metabolite |
| beta-Galactose dehydrogenase 可将半乳糖转化为半乳糖酸内酯，同时将 NAD 还原为荧光 NADH。 | |||
| M52611 | 3-Hydroxybutyrate dehydrogenase | 3-Hydroxybutyrate dehydrogenase | Metabolite/Endogenous Metabolite |
| 3-Hydroxybutyrate dehydrogenase (3-HBDH) 3-羟基丁酸脱氢酶是一种线粒体酶，常用于生化研究。 | |||
| M2297
|
Devimistat (CPI-613) | 德维司他 | Dehydrogenase |
| Devimistat | |||
| Devimistat (CPI-613) 是Lipoate类似物，抑制线粒体酶pyruvate dehydrogenase (PDH)（丙酮酸脱氢酶）和α-ketoglutarate dehydrogenase（α-酮戊二酸脱氢酶），干扰肿瘤细胞线粒体代谢。此外，Devimistat 也是TCA循环抑制剂。 | |||
| M4945
|
Enasidenib | 恩西地平；依那西尼 | Isocitrate Dehydrogenase (IDH) |
| AG-221 | |||
| Enasidenib（AG-221，恩西地平）是一种首创的（first-in-class），具有口服活性的，可逆的，选择性的 IDH2（Isocitrate dehydrogenase 2）突变酶抑制剂，抑制IDH2R140Q 和IDH2R172K 的 IC50 分别为100 nM和 400 nM。 | |||
| M7368 | TC-E 5008 | TC-E 5008 | Others |
| TC-E 5008 is a selective mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor; phenotypically lethal. | |||
| M8604
|
NCT-503 | NCT-503 | PHGDH |
| NCT503 | |||
| NCT-503是一种phosphoglycerate dehydrogenase (PHGDH)抑制剂，抑制细胞中3-磷酸甘油酸的丝氨酸合成，IC50值为2.5 μM。 | |||
| M8685 | GSK984 | GSK984 | Others |
| GSK984 is an inactive control probe for GSK983, which is an inhibitor of dihydroorotate dehydrogenase (DHODH) with antiviral activity. | |||
| M8753 | PKUMDL-WQ-2201 | PKUMDL-WQ-2201 | Others |
| PKUMDL-WQ-2201 is a potent and selective non-NAD+-competing allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) that selectively inhibits serine synthesis in cancer cells. | |||
| M9783
|
Sodium oxamate | 草氨酸钠 | LDH |
| Oxamic acid sodium salt | |||
| Sodium oxamate 草氨酸钠是一种 lactate dehydrogenase（LDH）的抑制剂，抑制L(+)-乳酸脱氢酶，使得整个糖异生途径脱轨，Sodium oxamate还抑制线粒体丙酮酸代谢机制。Sodium oxamate (SO) 通过下调 CDK1/cyclin B1 途径诱导G2/M细胞周期停滞，并通过增加线粒体内 ROS 的生成来促进凋亡。 | |||
| M9849
|
AZ-33 | AZ-33 | LDH |
| AZ33; LDHA Inhibitor 33 | |||
| AZ-33 是一种有效的 lactate dehydrogenase A (LDHA) 抑制剂，IC50值为0.5 μM。 | |||
| M10085
|
Mycophenolate mofetil | 吗替麦考酚酯；霉酚酸吗啉乙酯 | Dehydrogenase |
| MMF; RS 61443; TM-MMF; CAS# 128794-94-5 | |||
| Mycophenolate mofetil能够抑制B细胞增殖、抑制B细胞产生抗体；抑制T细胞增殖、抑制T细胞产生细胞因子，从而发挥免疫抑制作用。Mycophenolate mofetil是一种肌苷酸脱氢酶（Dehydrogenase）抑制剂霉酚酸(MPA)的前药。 | |||
| M14337 | 11beta-Hydroxyprogesterone | 11β-羟孕酮 | Metabolite/Endogenous Metabolite |
| 11β-Hydroxyprogesterone | |||
| 11beta-Hydroxyprogesterone是11β-羟基甾类脱氢酶(11β-Hydroxysteroid dehydrogenase)的有效抑制剂; 同时在COS-7细胞中激活人类盐皮质激素受体， ED50 值为10 nM。 | |||
| M20083 | WAY-313218 | WAY-313218 | Others |
| WAY-313218 is a 11β-hydroxysteroid dehydrogenase type 1 modulator | |||
| M20460 | 3-Methylpyrazole | 3-Methylpyrazole | Dehydrogenase |
| 3-MP | |||
| 3-Methylpyrazole (3-MP) is a weak or non-inhibitor of alcohol dehydrogenase. | |||
| M20485 | Phenylglyoxal hydrate | Phenylglyoxal hydrate | Dehydrogenase |
| 1-Phenylethanedione hydrate | |||
| Phenylglyoxal is a potent inhibitor of mitochondrial aldehyde dehydrogenase. It reacts with arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties. | |||
| M20682 | Frentizole | Frentizole | Amyloid |
| Frentizol | |||
| Frentizole is a novel inhibitor of amyloid beta peptide (Abeta) binding alcohol dehydrogenase (ABAD) interaction with IC50 of 200 μM. Frentizole is a nontoxic antiviral and immunosuppressive agent used clinically in rheumatoid arthritis and systemic lupus erythematosus. | |||
| M20770 | AKR1C1-IN-1 | AKR1C1-IN-1 | Others |
| AKR1C1-IN-1 is a potent and selective inhibitor of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) with Ki of 4 nM, 87 nM, 4.2 μM and 18.2 μM for AKR1C1, AKR1C2, AKR1C3 and AKR1C4, respectively. | |||
| M20802 | 6-Aminonicotinamide | 6-Aminonicotinamide | Dehydrogenase |
| 6AN | |||
| 6-Aminonicotinamide (6AN) is an antimetabolite used to inhibit the NADPH-producing pentose phosphate pathway (PPP) in many cellular systems, making them more susceptible to oxidative stress. 6-Aminonicotinamide is a competitive inhibitor of NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) with Ki of 0.46 μM. | |||
| M20857 | Ethyl potassium malonate | Ethyl potassium malonate | Others |
| Potassium 3-ethoxy-3-oxopropanoate, Malonic Acid Monoethyl Ester Potassium Salt | |||
| Ethyl potassium malonate is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation and serves as an intermediate for the preparation of ethyl tert-butyl malonate. | |||
| M28312 | ME1111 | ME1111 | Antifungal |
| ME1111 是一种具有抗皮肤真菌活性的抗真菌剂。ME1111 是毛癣菌属琥珀酸脱氢酶 (succinate dehydrogenase) 的抑制剂。ME1111 对人类指甲有良好的穿透性，被用于甲真菌病的研究。 | |||
| M39566 | Octanoyl coenzyme A lithium | 辛酰基辅酶A锂盐 | Others |
| Octanoyl coenzyme A lithium 是脂肪酸酰基辅酶 A 的衍生物。Octanoyl coenzyme A lithium 对柠檬酸合成酶 (citrate synthase) 和谷氨酸脱氢酶 (glutamate dehydrogenase) 具有抑制作用，其 IC50 值为 0.4-1.6 mM。 | |||
| M41136 | SDH-IN-4 | SDH-IN-4 | Antifungal |
| SDH-IN-4 是一种琥珀酸脱氢酶 (succinate dehydrogenase (SDH)) 抑制剂，IC50 值为 0.28 μg/mL。 | |||
| M41141 | Penflufen | Penflufen | Antifungal |
| Penflufen 是一种高效、广谱的琥珀酸脱氢酶 (succinate dehydrogenase) 抑制剂。 | |||
| M42381 | 3-Butynoic acid | 3-Butynoic acid | Metabolite/Endogenous Metabolite |
| 3-Butynoic acid 是一种酰基辅酶A脱氢酶 (acyl CoA dehydrogenase) 抑制剂。 | |||
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