找到约 31 条 “Astin C” 相关结果 （用时 0.095 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M2602
|
Hydrastinine hydrochloride | Hydrastinine hydrochloride | Others |
| Hydrastinine hydrochloride is a semisynthetic alkaloid from the hydrolysis of the alkaloid hydrastine, which was found naturally in small quantities in Hydrastis canadensis L. | |||
| M2671
|
Epinastine hydrochloride | 依匹斯汀盐酸盐 | Histamine Receptor |
| WAL801 hydrochloride | |||
| Epinastine HCl是一种抗组胺剂和肥大细胞稳定剂。Epinastine hydrochloride 是一种有效的，选择性的，具有口服活性的组胺 H1 受体 (histamine H1 receptor) 拮抗剂。 | |||
| M3487
|
Azelastine hydrochloride | 盐酸氮卓斯汀 | Histamine Receptor |
| Azelastine HCl是有效的，第二代选择性组胺拮抗剂。 | |||
| M7888 | Levocabastine hydrochloride | 左旋多巴 | Others |
| Non-peptide histamine H1 receptor antagonist; neurotensin NTS2 receptor ligand. | |||
| M14232 | Rapastinel Trifluoroacetate | Rapastinel Trifluoroacetate | GluR |
| GLYX-13 Trifluoroacetate | |||
| Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) 是一种具有甘氨酸位点部分激动剂性质的 NMDA 受体调节剂。Rapastinel Trifluoroacetate 有潜力用于抑郁症的研究 | |||
| M16098 | Murrastinine C | Murrastinine C | Alkaloids |
| Murrastinine C | |||
| M20495 | Cloperastine hydrochloride | Cloperastine hydrochloride | Histamine Receptor |
| HT-11 hydrochloride | |||
| Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic activity. | |||
| M20720 | Vindesine sulfate | Vindesine sulfate | Microtubule |
| Eldesine, Eldisine, Desacetyl Vinblastine amide, Desacetylvinblastine amide, DAVA, DVA, VDS | |||
| Vindesine sulfate (Eldesine, Eldisine, Desacetyl Vinblastine amide, Desacetylvinblastine amide, DAVA, DVA, VDS), a vinca alkaloid derived from Catharanthus roseus, is a potent inhibitor of mitosis with antineoplastic activities. Vindesine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. | |||
| M43712
|
Astin C | Astin C | Others |
| Astin C (Asterin) 是一种具有抗癌和抗炎特性的环状五肽。 | |||
| M1702
|
DCC-2036 | 瑞巴斯替尼 | Src-bcr-Abl |
| Rebastinib | |||
| DCC-2036 (Rebastinib)是一种Bcr-Abl抑制剂，作用于Abl1(WT)和Abl1(T315I)，IC50分别为0.8 nM和4 nM，也抑制SRC， LYN， FGR， HCK， KDR， FLT3，和Tie-2，对c-Kit具有低的抑制活性。 | |||
| M2449
|
Bepotastine Besilate | 苯磺酸贝托司汀 | Histamine Receptor |
| Bepotastine Besilate是一种非镇静作用的，选择性的组胺1 (H1)受体拮抗剂，pIC50为5.7。 | |||
M2679
|
Erastin | 铁死亡诱导剂 | Ferroptosis |
| Erastin是一种SLC7A11抑制剂，以及ferroptosis激活剂，能通过作用于线粒体VDAC而起作用，选择性作用于携带致癌基因RAS的肿瘤细胞。*该产品在溶液状态不稳定，建议您现配现用 | |||
| M2698
|
Ferrostatin-1 | 铁抑素-1 | Ferroptosis |
| Fer-1 | |||
| Ferrostatin-1 (Fer-1)是一种有效的选择性的ferroptosis抑制剂，抑制Erastin诱导的HT-1080细胞铁死亡，EC50为60 nM。 | |||
| M3318
|
Clemastine Fumarate | 富马酸氯马斯汀 | Histamine Receptor |
| Meclastine fumarate | |||
| Clemastine Fumarate是一种选择性组胺H1受体拮抗剂，IC50为3 nM。 | |||
| M3912
|
Vinblastine sulfate | 硫酸长春碱 | Microtubule |
| Vincaleukoblastine sulfate salt | |||
| Vinblastine sulfate（硫酸长春碱）是一种具有广谱抗肿瘤活性的生物碱，能够抑制细胞内微管的形成和有丝分裂。此外，它还能够抑制nAChR的活性，其IC50值为8.9μM。 | |||
| M4551
|
Trigonelline hydrochloride | 葫芦巴碱盐酸盐 | Anti-infection |
| Trigonelline chloride | |||
| Trigonelline hydrochloride 是一种NRF2抑制剂，可阻断血红素和铁代谢相关的NRF2靶基因的表达，与erastin和索拉菲尼协同作用，可促进肝癌细胞的铁死亡。此外，Trigonelline hydrochloride 还能穿透大脑，并可直接结合以及激活肌酸激酶 B(CKB)，从而诱导轴突和树突生长。 | |||
| M5792
|
Mizolastine | 咪唑司汀 | Histamine Receptor |
| SL 850324 | |||
| Mizolastine 是一种组胺H1受体拮抗剂，IC50为47 nM，用于治疗花粉症（季节性过敏性鼻炎）、荨麻疹和其他过敏性反应。 | |||
| M7923 | Myoseverin B | Myoseverin B | Others |
| Myoseverin, a new microtubule-binding molecule, acts reversibly on myoblast proliferation without the cytotoxic effects displayed by nonpurine-based microtubule-disrupting molecules, like taxol, vinblastine, nocodazole. | |||
| M8311
|
MLR-1023 | MLR-1023 | Src-bcr-Abl |
| Tolimidone | |||
| MLR-1023 (Tolimidone) is a potent, orally active, allosteric activator of the non-receptor Src-related Lyn kinase that produces lasting glucose lowering, reduces HbA1c levels, and preserves pancreatic β-cells in db/db mice. | |||
| M8599 | Epiblastin A | Epiblastin A | Others |
| Epiblastin A是一种三苯氧胺衍生物，是一种 ATP 竞争性的酪蛋白激酶 1 (CK1) 抑制剂，对 CK1α， CK1δ， 和CK1 ɛ 的 IC50 分别为 8.9， 0.5，和 4.7 µM。此外，Epiblastin A 还能通过抑制 CK1 诱导外胚层干细胞重编程为胚胎干细胞。 | |||
| M8613
|
CDN1163 | CDN1163 | Others |
| CDN1163 is an allosteric activator of sarco/ endoplasmic reticulum Ca2+-ATPase (SERCA) that potently lowered fasting blood glucose, improved glucose tolerance and ameliorated hepatosteatosis in ob/ob mice. | |||
| M9172
|
Emedastine Difumarate | 富马酸依美斯汀 | Histamine Receptor |
| Rapimine | |||
| Emedastine Difumarate is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. | |||
| M10244
|
Imidazole ketone erastin | Imidazole ketone erastin | Ferroptosis |
| Ferroptosis inducer IKE; PUN-30119 | |||
| Imidazole ketone erastin (IKE) 是一个ferroptosis铁死亡的诱导剂，它也是一种有效的，选择性的，代谢稳定的system xc–抑制剂。 | |||
| M10259
|
Spastazoline | 斯巴达唑啉 | Others |
| Spastazoline 是一种有效的，选择性aaa+（与多种细胞活动相关的 atpases）蛋白抑制剂，抑制微管切断aaa+蛋白 spastin，它对人spastin的IC50值为99 nM。 | |||
| M13991 | Bepotastine | 贝他斯汀；贝托司汀；贝托斯汀；贝他司汀 | Histamine Receptor |
| Bepotastine 是一种选择性的具有口服活性的第二代组胺 H1 受体 (histamine H1 receptor) 拮抗剂。Bepotastine 可用于过敏性鼻炎，过敏性结膜炎和荨麻疹/瘙痒症的研究。 | |||
| M20452 | Revaprazan Hydrochloride | Revaprazan Hydrochloride | Proton Pump |
| YH1885 | |||
| Revaprazan Hydrochloride is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects. | |||
| M20515 | Emedastine | Emedastine | Histamine Receptor |
| Emedastine is a potent, high affinity histamine H1-receptor-selective antagonist with Ki of 1.3 ±0.1 nM for H1-receptors while considerably weaker at H2- (K1 = 49,067 ± 11,113 nM) and H3-receptors (Ki = 12,430 ± 1,282 nM). | |||
| M21708
|
Erastin2 | Erastin2 | Ferroptosis |
| Erastin2 是一种ferroptosis铁死亡的诱导剂，是 xc (-) 胱氨酸/谷氨酸转运体系统的有效的选择性抑制剂。 | |||
| M28692 | Bezuclastinib | Bezuclastinib | c-Kit |
| CGT9486; PLX 9486 | |||
| Bezuclastinib (CGT9486; PLX 9486) 是一种有效的 c-kit 和c-kit D816V 抑制剂，0.0001 < IC50 < 1 μM。Bezuclastinib 是一种酪氨酸激酶抑制剂。 | |||
| M30621 | Levocabastine | Levocabastine | Histamine Receptor |
| R 50547 | |||
| Levocabastine (R 50547) 是一种强效选择性组胺 H1 受体拮抗剂。Levocabastine 也是一种选择性、高亲和力的神经降压素受体亚型 2 (NTR2) 拮抗剂，对 mNTR2 的 Ki 值为 17 nM。Levocabastine 可作为 VLA-4 拮抗剂，干扰过敏性结膜炎 (AC) 结膜嗜酸性粒细胞的浸润。 | |||
| M38852 | Astin B | Astin B | Apoptosis |
| Astin B 是一种口服有效的环状五肽，可从 Aster tataricus 中分离得到。Astin B 在体外和体内均具有肝毒性作用，肝损伤主要由线粒体/半胱天冬酶依赖性方式的细胞凋亡 (apoptosis) 介导。 | |||
