Dorsomorphin dihydrochloride 别名：BML-275 2HCl; Compound C 2HCl

目录号 M2238

Dorsomorphin (BML-275; Compound C)二盐酸盐是一种有效的，可逆的AMPK选择性抑制剂，K_i为109 nM，Dorsomorphin还对BMP有抑制作用。

CAS No.：1219168-18-9

规格	价格	库存状态
Free Sample (0.5-1 mg)	¥ 0	现货
10mM*1mL in DMSO	¥ 490	现货
5mg	¥ 460	现货
10mg	¥ 680	现货
25mg	¥ 1380	现货
50mg	¥ 2670	现货

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客户使用AbMole的Dorsomorphin dihydrochloride发表的文献

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质量标准及产品资料

纯度：99.67%
COA
H-NMR
HPLC

化学性质/溶解性/储存

分子量	472.41
分子式	C24H25N5O.2HCl
CAS号	1219168-18-9
溶解性	Water 45 mg/mL DMSO 5 mg/mL (Need ultrasonic)
储存条件	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月
运输方式	冰袋运输，根据产品的不同，可能会有相应调整。

生物活性

Dorsomorphin（BML-275; Compound C）二盐酸盐是一种有效的，可逆的AMPK选择性抑制剂，K_i为109 nM，Dorsomorphin还对BMP有抑制作用。BML-275二盐酸盐对AMPK活性的抑制几乎完全抑制了HT-29细胞中的自体吞噬的蛋白质水解作用。此外，BML-275二盐酸盐选择性抑制BMP I型受体ALK2，ALK3和ALK6，并因此阻断BMP介导的SMAD1/5/8磷酸化作用，靶点基因转录和成骨分化。Dorsomorphin (10 毫克/千克)在成年小鼠体内，降低肝杀菌肽表达的基础水平，并增加血清中铁离子浓度。Dorsomorphin (0.2 毫克/千克，静脉注射)显著减少LPS 处理的大鼠胸主动脉中VCAM-1 和 ICAM-1的表达。

实验参考

蛋白/细胞实验

下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前，需考虑其在不同溶剂中的溶解度限制。

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.1168 mL	10.584 mL	21.1681 mL
5 mM	0.4234 mL	2.1168 mL	4.2336 mL
10 mM	0.2117 mL	1.0584 mL	2.1168 mL

*吸湿的DMSO对产品的溶解度有显著影响，请使用新开封的DMSO；
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

质量		浓度		体积		分子量*
	=		x		x

细胞系	Spermatogonial Cell
方法	Dorsomorphin was added to the medium at a final concentration of 0, 1, 2, 4, or 8 µM (in final 0.4% dimethyl sulfoxide). The cells were maintained at 28.5°C in an atmosphere of 3% carbon dioxide and the medium was replaced every 3–4 days.
浓度	0, 1, 2, 4, or 8 µM
处理时间	3 weeks

* 上述方法来自公开文献，仅供相同目的实验参考。如实验目的、材料、方法不同，请参考其他文献。

动物实验

建议您制定动物给药及实验方案时，尽量参考已发表的相关实验文献（溶剂种类及配比众多，简单地溶解目的化合物，并不能解决动物给药依从性、体内生物利用度、组织分布等相关问题，未必能保证目的化合物在动物体内充分发挥生物学效用）。
体内实验的工作液，建议您现用现配，当天使用；如在配制过程中出现沉淀、析出现象，可以通过超声和（或）加热的方式助溶。
切勿一次性将产品全部溶解。