找到约 34 条 “TS-IN-2” 相关结果 （用时 0.084 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M4067
|
Ginsenoside-Rg2 | 人参皂苷 Rg2 | NF-κB |
| Chikusetsusaponin I; Panaxoside Rg2; Prosapogenin C2 | |||
| 人参皂苷Rg2 Ginsenoside Rg2是人参的主要活性成分之一。Ginsenoside-Rg2可以通过Nrf2增加抗氧化作用，并通过抑制细胞中的STAT3/TAK1和NF-κB信号通路增加抗炎活性。 | |||
| M21451
|
Recombinant Human Cathepsin K protein (E.coli) | 重组人Cathepsin K 蛋白（E.coli） | Cytokines and Growth Factors |
| CTSK；Cathepsin K；Cathepsin O；Cathepsin O2 | |||
| 蛋白构造：编码人类CTSK (Ala115-Met329)的DNA序列与His标签融合。Accession #P43235。 | |||
| M41372 | TS-IN-2 | TS-IN-2 | Others |
| TS-IN-2 是一种胸苷酸合酶(TS)抑制剂，IC50 值为 0.81 μM。 | |||
| M51402 | KWKHGAEIVYKSPVV-{S(GlcNAc-β-D)}-GDTSPRHLSNVK-{K(biotinyl)}-NH2 | KWKHGAEIVYKSPVV-{S(GlcNAc-β-D)}-GDTSPRHLSNVK-{K(biotinyl)}-NH2 | Others |
| KWKHGAEIVYKSPVV-{S(GlcNAc-β-D)}-GDTSPRHLSNVK-{K(biotinyl)}-NH2 是一种多肽，能够由多肽筛选发现。 | |||
| M4089
|
Ginsenoside-Ro | 竹节参皂苷V | Calcium Channel |
| Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V; Ginsenoside-Ro | |||
| Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V) 具有 Ca2+ 拮抗剂的抗血小板作用，IC50 为 155 μM。Ginsenoside Ro 降低 TXA2 产量，Ginsenoside Ro 还稍弱地降低 COX-1 和 TXAS 活性。 | |||
| M40771
|
Recombinant Human CTLA-4 Protein (HEK293, C-6His) | 重组人CTLA-4蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
| Cytotoxic T-lymphocyte-associated antigen 4 | |||
| Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. | |||
| M7330
|
Meclinertant | Meclinertant | Neurotensin Receptor |
| SR 48692 | |||
| Meclinertant (SR 48692) 是一种有效的，选择性的，非肽和口服活性神经降压素受体 (NTS1) 拮抗剂。在人结肠癌细胞中，Meclinertant 竞争性拮抗神经降压素诱导的细胞内 Ca2+ 动员，pA2 值为 8.13。Meclinertant 具有抗焦虑，抗上瘾和记忆障碍的作用。 | |||
| M7680 | PK 11195 | PK 11195 | Parasite |
| RP 52028 | |||
| PK 11195是一种TSPO蛋白（Translocator protein）的配体，它也是一种外周型苯二氮卓受体（Peripheral-type benzodiazepine receptor）的拮抗剂。PK 11195具有抗炎特性，可结合单核细胞，并在脑损伤后与脑巨噬细胞和激活的小胶质细胞结合。此外，它还能增强 DNA 损伤剂诱导细胞凋亡的能力。PK 11195还对利什曼原虫具有抑制活性，对不同种类的利什曼原虫（L. amazonensis、L. major 和 L. braziliensis）的 IC₅₀值分别为14.2 μM、8.2 μM和3.5 μM。 | |||
| M7711 | Cloricromene | Cloricromene | Others |
| Antithrombotic coumarin derivative that inhibits platelet and leukocyte function and suppresses arachidonic acid liberation by interfering with PLA2 activation. | |||
| M7725 | CK-548 | CK-548 | Others |
| CK-548 inhibits the activity of actin-related protein (Arp)2/3 complex by inserting into the hydrophobic core of Arp3 and altering its conformation: inhibits. | |||
| M7827 | HA-1077 dihydrochloride | HA-1077 dihydrochloride | Others |
| Novel vasodilator agent which inhibits vascular smooth muscle contraction by acting as an intracellular Ca2+ antagonist. | |||
| M8249 | EM20-25 | EM20-25 | Others |
| EM20-25 disrupts the BCL-2/BAX interactions and activates caspase-9 in cells overexpressing BCL-2. | |||
| M40772
|
Recombinant Human CTLA-4 Protein (HEK293, C-Flag) | 重组人CTLA-4蛋白 (HEK293, C-Flag) | Cytokines and Growth Factors |
| Cytotoxic T-lymphocyte-associated antigen 4 | |||
| Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. | |||
| M8301 | MJC13 | MJC13 | Others |
| MJC13 inhibits the positive regulation of androgen receptor (AR) signaling by the cochaperone protein FKBP52. | |||
| M8353 | SPA0355 | SPA0355 | Others |
| SPA0355 inhibits cytokine and LPS-induced activation of NF-kB in cell-based assays, blocking IKK-2 phosphorylation, degradation, and p65 binding to DNA. | |||
| M8463 | FFN102 | FFN102 | Monoamine Transporter |
| FFN102 is a pH-responsive fluorescent false neurotransmitter that acts as a dopamine transporter substrate (DAT) and also a substrate for vesicular monoamine transporter 2 (VMAT2). | |||
| M8468 | PYZD-4409 | PYZD-4409 | Others |
| PYZD-4409 inhibts ATP-dependent activation of human ubiquitin activating enzyme E1 with an IC50 of 20 mM. | |||
| M8473 | RA-9 | RA-9 | Others |
| RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 20S proteasome catalytic-core activity. | |||
| M8506
|
ML351 | ML351 | Lipoxygenase |
| ML351 is a cell penetrant, selective and highly potent human lipoxygenase-12/15 (15-Lipoxygenase-1, 12/15-LOX) inhibitor that exhibits protective effects against oxidative glutamate toxicity in mouse neuronal HT22 cells. | |||
| M8526 | MS37452 | MS37452 | Others |
| MS37452 is a selective Chromobox homolog 7 (CBX7) modulator that disrupts CBX7ChD binding to H3K27me3. | |||
| M8557 | CS1 | CS1 | Others |
| CS1 is a selective and potent inhibitor of topoisomerase IIα (TopoIIα) that potently inhibits a proliferation of cancer cell lines including MDA-MB-231 and A548 cells, with less toxicity than etoposide. | |||
| M8596 | WWL70 | WWL70 | Others |
| WWL70 is a selective inhibitor of α/β-hydrolase domain-containing 6 (ABHD6), a serine hydrolase that acts as an alternative hydrolase of the endocannabinoid 2-arachidonoylglycerol (2-AG). | |||
| M8609 | MM-206 | MM-206 | Others |
| MM-206 is a cell-permeable, non-cytotoxic naphthalene sulfonamide compound effectively inhibits STAT3 DNA-binding activity (IC50 = 2. | |||
| M8611 | Ex26 | Ex26 | S1P Receptor |
| Ex26 is a peripherally-restricted biphenylcarboxamide derivative that acts as a highly potent and subtype-selective S1P1 antagonist (IC50 = 0.93 nM against S1PR1 and >3.1 μM against S1PR2/3/4/5). | |||
| M8624 | HPB | HPB | Others |
| HPB is a cell-permeable, non-cytotoxic N-hydroxybenzamide derivative that acts as a HDAC6-selective deacetylase inhibitor (IC50 = 31/376/677/842/1133 nM against HDAC6/8/10/1/7, >2 μM against HDAC2/3/4/11/9/5). | |||
| M8709 | KIN1408 | KIN1408 | Others |
| KIN1408 is a small molecule that targets factors at or above the level of MAVS in the RLR signaling pathway to drive IRF3 activation (IRF3 nuclear translocation ECmax = 5 μM in 20 h; Huh7 cells) without significant cytotoxicity. | |||
| M8770 | Didox | Didox | Others |
| N,3,4-Trihydroxybenzamide | |||
| Didox is a ribonucleotide reductase (RNR) inhibitor that inhibits proliferation of and decreased secretion of cytokines IL-6, IFN-g, TNF-a, IL-2, IL-13, IL-10 and IL-4. | |||
| M8773 | Liarozole dihydrochloride | Liarozole dihydrochloride | Others |
| Liarozole (R 75251, R75,251) is an orally active benzimidazole-based retinoic acid (RA) metabolism blocking agent (RAMBA) that targets multiple P450 enzymes, including aromatase (CYP19), 17-hydroxylase/17,20-lyas |
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| M9465
|
MAZ51 | MAZ51 | VEGFR/PDGFR |
| MAZ-51 | |||
| MAZ51 is originally synthesized inhibitor of VEGFR-3 (Flt-4) tyrosine kinase, inhibits VEGF-C-induced activation of VEGFR-3 without blocking VEGF-C-mediated stimulation of VEGFR2. | |||
| M40601
|
Recombinant Human IL-3 Protein (CHO) | 重组人IL-3蛋白 (CHO) | Cytokines and Growth Factors |
| Interleukin-3 | |||
| Interleukin-3 (IL-3) is a pleiotropic cytokine belonging to the interleukin family. IL-3 inhibits apoptosis and promotes cell survival by targeting the anti-apoptotic bcl-2 gene family. | |||
| M55325
|
Recombinant Human IL-29/IFN-λ1 (HEK293, C-10His) | 重组人IL-29/IFN-λ1 (HEK293, C-10His) | Cytokines and Growth Factors |
| Interleukin-29; Interferon lambda-1; IFN-lambda-1 | |||
| Interleukin-29 (IL-29; IFN-λ1) is a cytokine with immunomodulatory activity. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL-29 may play a role in antiviral immunity. | |||
| M15012
|
Recombinant Human TIMP-2 (HEK293,C-6His) | 重组人TIMP-2蛋白（HEK293,C-6His） | Cytokines and Growth Factors |
| Metalloproteinase Inhibitor 2; CSC-21K | |||
| TIMP-2 is a non N-glycosylated protein with a molecular mass of 22 kDa. It produced by a wide range of cell types, which inhibits MMPs non-covalently by the formation of binary complexes and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-2 also has erythroid‑potentiating and cell growth promoting activities. | |||
| M15009
|
Recombinant Human R-spondin 1/RSPO1 (HEK293, His) | 重组人R-spondin 1/RSPO1蛋白 (HEK293, His) | Cytokines and Growth Factors |
| R-spondin-1; Roof plate-specific spondin-1 | |||
| R-spondin-1/RSPO1是一种能激活Wnt信号传导的分泌蛋白，含有2个FU (furin-like) 重复序列和1个TSP type-1结构域，属于R-spondin家族。蛋白编号：Q2MKA7-1 (R31-A263)。 | |||
| M40923
|
Recombinant Human IL31RA Protein (HEK293, C-His) | 重组人IL31RA蛋白 (HEK293, C-His) | Cytokines and Growth Factors |
| interleukin 31 receptor A | |||
| The recombinant human IL31RA consists 508 amino acids and predicts a molecular mass of 58.2 kDa. A DNA sequence encoding the human IL31RA (Met1-Ser516) was expressed with a polyhistidine tag at the C-terminus. | |||
