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Recombinant Human Cathepsin K protein (E.coli) 重组人Cathepsin K 蛋白(E.coli)

目录号 M21451 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


蛋白构造:编码人类CTSK (Ala115-Met329)的DNA序列与His标签融合。Accession #P43235。

Recombinant Human Cathepsin K protein (E.coli)结构式

别名:CTSK;Cathepsin K;Cathepsin O;Cathepsin O2

规格 价格 库存状态
50ug ¥ 3600 中国库存现货
其他规格数量报价?

质量标准及产品资料
生物活性

种属:Human

表达系统:E.coli

纯度:>90%由SDS-PAGE测定

预测分子量:25.81 kDa

存储及稳定性:使用手动解冻冰柜,避免重复冻融循环。在2 - 8°C保存一周。从收到之日起在-20至-80°C保存12个月。


生物活性:硫醇蛋白酶参与破骨细胞骨吸收,可能部分参与骨重塑紊乱。在酸性ph值下对纤维蛋白原显示出强大的内蛋白酶活性。可能在细胞外基质降解中发挥重要作用。在甲状腺滤泡腔内通过有限的TG/甲状腺球蛋白蛋白水解参与甲状腺激素甲状腺素(T4)的释放

化学性质
溶解性(25°C) Reconstitute in sterile water for a stock solution.
储存条件 粉末型式       -20°C   3年;4°C   2年
溶于溶剂       -80°C   6个月;-20°C   1个月
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Dongzheng Gai, et al. J Clin Invest. CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation

[2] Huaqiang Tao, et al. Pharmacol Res. Urolithin A suppresses RANKL-induced osteoclastogenesis and postmenopausal osteoporosis by, suppresses inflammation and downstream NF-κB activated pyroptosis pathways

[3] Rui Li, et al. Cell Death Differ. Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer

[4] Jennifer A Bennett, et al. Am J Surg Pathol. Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors

[5] F Bhling, et al. Adv Exp Med Biol. Cathepsin K expression in human lung

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