R-spondin-1/RSPO1是一种能激活Wnt信号传导的分泌蛋白，含有2个FU (furin-like) 重复序列和1个TSP type-1结构域，属于R-spondin家族。蛋白编号：Q2MKA7-1 (R31-A263)。
别名：R-spondin-1; Roof plate-specific spondin-1
R-Spondin-1 (Rspo-1)属于 Wnt 调制器(Rspo)家族。目前，该家族由四个结构相关的分泌性配体(Rspo 1-4)组成，均 含有碱性残基和血栓反应蛋白结构域。R-Spondin-1 是一种分泌的激活蛋白质，含有两个相邻的半胱氨酸呋喃结构 域（aa 34-135），具有一个潜在的 N-糖基化位点，其次是血栓孢素（TSP1）基序（aa 147-207）和富含碱性残基 的区域（aa 211-263）。Rspo-1 表达于发育中的中枢神经系统的某些区域，以及肾上腺、卵巢、睾丸、甲状腺和气 管。Rspo 可以与 Frizzled/LRP6 受体复合物相互作用，以刺激 Wnt/ β -catenin 信号通路。
蛋白序列：DNA 序列编码人 R-spondin 1（Q2MKA7.1）蛋白，带 His 标签在 C 端
分子量：预测分子量为 28 kD，由于糖基化修饰实际条带在 45kD 左右
剂型描述：冻干制剂
| 溶解性（25°C） | Reconstitute the lyophilized powder in ddH2O or PBS to 100 μg/ml |
| 储存条件 | Stable for up to 12 months at -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 6 months at -20°C. |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
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蛋白质研究