找到约 38 条 “P-T-P-S-NH2” 相关结果 （用时 0.101 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M5619
|
Eptifibatide | 依替巴肽；依非巴特 | Integrin |
| MPA-HAR-Gly-Asp-Trp-Pro-Cys-NH2; {MPA}{HAR}GDWPC-NH2 | |||
| Eptifibatide为抗血小板化合物，同时也是糖蛋白IIb/IIIa（CD41/CD61）的大环类抑制剂。 | |||
| M10565
|
Kisspeptin-10, human TFA | 亲吻促动素-10(人源)三氟乙酸盐 | Peptides |
| KP-10; Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 | |||
| Kisspeptin-10, human TFA 是一种有效的血管收缩剂和血管生成抑制剂，它通过其受体 GPR54 来抑制肿瘤转移作用。Kisspeptin-10/GPR54 信号通过 NFATc4 介导的 BMP2 表达来诱导成骨细胞分化。 | |||
| M20860 | Eptifibatide Acetate | Eptifibatide Acetate | Others |
| Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2 | |||
| Eptifibatide Acetate is a cyclic heptapeptide constructed from 6 amino acids and a mercaptopropionyl residue. A disulfide bridge forms between mercaptopropionyl and cysteine. Eptifibatide prevents platelet aggregation. One study shows the inhibition of platelet glycoprotein IIb/IIIa in acute coronary syndromes. | |||
| M50591 | P-T-P-S-NH2 | P-T-P-S-NH2 | Others |
| P-T-P-S-NH2 是一种具有 N-末端脯氨酸的短链肽。 | |||
| M51402 | KWKHGAEIVYKSPVV-{S(GlcNAc-β-D)}-GDTSPRHLSNVK-{K(biotinyl)}-NH2 | KWKHGAEIVYKSPVV-{S(GlcNAc-β-D)}-GDTSPRHLSNVK-{K(biotinyl)}-NH2 | Others |
| KWKHGAEIVYKSPVV-{S(GlcNAc-β-D)}-GDTSPRHLSNVK-{K(biotinyl)}-NH2 是一种多肽，能够由多肽筛选发现。 | |||
| M51469 | NBD-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys-(DMC)-NH2 | NBD-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys-(DMC)-NH2 | Others |
| NBD-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys-(DMC)-NH2 是基质金属蛋白酶溶质素 (MMP-3) 水解的底物，可在 Abs/Em=350/465 nm 检测。 | |||
| M52569 | Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 | Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 | MMP |
| Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 是一种有生物活性的肽。 | |||
| M53494 | Hepatitis Virus C NS3 Protease Inhibitor 2 | Hepatitis Virus C NS3 Protease Inhibitor 2 | HCV Protease |
| Hepatitis Virus C NS3 Protease Inhibitor 2 是基于产物的丙型肝炎病毒蛋白酶 ( HCV NS3 protease) 肽抑制剂，其 Ki 值为 41 nM。 | |||
| M3634
|
TAPI-1 | TAPI-1 | Immunology/Inflammation |
| TAPI-1（TNF-α processing inhibitor-1）是一种ADAM17/TACE(TNF-α转化酶)抑制剂，可通过抑制TACE 介导的可溶性TNF-α及其受体的释放，从而减少其他炎症因子的产生。此外，TAPI-1能在稳定表达M3毒蕈碱受体的HEK-293细胞中，减少组成型和毒蕈碱受体刺激的sAPP释放，IC50分别为8.09 μM和3.61 μM，可用于关节炎的相关研究， | |||
| M5027
|
CPI-169 racemate | CPI-169 racemate | EZH2 |
| CPI-169 racemate is the racemate form of CPI-169, which is a novel and potent EZH2 inhibitor with IC50 <1 nM(inhibition of the catalytic activity of PRC2). | |||
| M40771
|
Recombinant Human CTLA-4 Protein (HEK293, C-6His) | 重组人CTLA-4蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
| Cytotoxic T-lymphocyte-associated antigen 4 | |||
| Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. | |||
| M6651 | Damnacanthal | 丹宁卡；丹拿堪索 | Others |
| Damnacanthal is a potent, selective p56 lck inhibitor; also LIMK1/2 inhibitor. | |||
| M40772
|
Recombinant Human CTLA-4 Protein (HEK293, C-Flag) | 重组人CTLA-4蛋白 (HEK293, C-Flag) | Cytokines and Growth Factors |
| Cytotoxic T-lymphocyte-associated antigen 4 | |||
| Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. | |||
| M8382
|
kb-NB142-70 | kb-NB142-70 | Others |
| kb-NB142-70 is a derivative of the PKD1 inhibitor CID755673, with approximately 6-fold greater potency (IC50 for inhibition of PKD1 = 28. | |||
| M8415 | CID44216842 | CID44216842 | Others |
| CID44216842 is a potent and selective non-competitive allosteric inhibitor of Cdc42 GTPase that does not inhabit Rho and Rac. | |||
| M8506
|
ML351 | ML351 | Lipoxygenase |
| ML351 is a cell penetrant, selective and highly potent human lipoxygenase-12/15 (15-Lipoxygenase-1, 12/15-LOX) inhibitor that exhibits protective effects against oxidative glutamate toxicity in mouse neuronal HT22 cells. | |||
| M8557 | CS1 | CS1 | Others |
| CS1 is a selective and potent inhibitor of topoisomerase IIα (TopoIIα) that potently inhibits a proliferation of cancer cell lines including MDA-MB-231 and A548 cells, with less toxicity than etoposide. | |||
| M8609 | MM-206 | MM-206 | Others |
| MM-206 is a cell-permeable, non-cytotoxic naphthalene sulfonamide compound effectively inhibits STAT3 DNA-binding activity (IC50 = 2. | |||
| M8640
|
SW044248 | SW044248 | Topoisomerase |
| SW044248 is a cell permeable, indolotriazine-based compound that selectively inhibits topoisomerase 1 (Top 1), but not Top 2, catalyzed DNA decatenation in a manner distinct from that of camptothecin (Cat. | |||
| M8743 | FPMINT | FPMINT | Others |
| FPMINT is a potent, irreversible and non-competitive inhibitor of equilibrative nucleoside transporters ENT1 and ENT2. | |||
| M10237
|
Protease-Activated Receptor-2, amide | 蛋白酶激活的受体-2,酰胺 | PAR |
| SLIGKV-NH2 | |||
| Protease-Activated Receptor-2, amide (SLIGKV-NH2) 是一种针对蛋白酶激活受体 2 (PAR-2) 的肽类激动剂，主要用于炎症和疼痛研究。 | |||
| M10559
|
Tyrphostin A1 | Tyrphostin A1 | IL Receptor/Related |
| Tyrphostin 1 | |||
| Tyrphostin A1 is a weaker EGFR tyrosine kinase inhibitor, Tyrphostin A1 inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. | |||
| M13682 | HSP27 inhibitor J2 | HSP27 inhibitor J2 | HSP |
| HSP27 inhibitor J2 (J2) 是一种 HSP27 抑制剂，其显著诱导异常 HSP27 二聚体形成并抑制 HSP27 巨聚合物的产生，从而具有抑制 HSP27 的伴侣功能和降低其细胞保护功能的作用。HSP27 inhibitor J2 (J2) 显著增强 17-AAG 的抗增殖活性，并对顺铂诱导的肺癌细胞生长抑制具有敏感性。 | |||
| M14157
|
D-JNKI-1 | D-JNKI-1 | JNK |
| AM-111; XG-102; Brimapitide | |||
| D-JNKI-1 (AM-111) 是高效可渗透细胞的 JNK 抑制剂。序列: Asp-Gln-Ser-Arg-Pro-Val-Gln-Pro-Phe-Leu-Asn-Leu-Thr-Thr-Pro-Arg-Lys-Pro-Arg-Pro-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly-NH2。 | |||
| M14303 | CPA inhibitor | CPA inhibitor | Others |
| Carboxypeptidase inhibitor | |||
| CPA inhibitor (Carboxypeptidase inhibitor; compound 5) 是一种有效的羧肽酶 A (CPA) 抑制剂，Ki 值为 0.32 μM。 | |||
| M15012
|
Recombinant Human TIMP-2 (HEK293,C-6His) | 重组人TIMP-2蛋白（HEK293,C-6His） | Cytokines and Growth Factors |
| Metalloproteinase Inhibitor 2; CSC-21K | |||
| TIMP-2 is a non N-glycosylated protein with a molecular mass of 22 kDa. It produced by a wide range of cell types, which inhibits MMPs non-covalently by the formation of binary complexes and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-2 also has erythroid‑potentiating and cell growth promoting activities. | |||
| M15097
|
α-CGRP (mouse, rat) (TFA) | α-CGRP (mouse, rat) (TFA) | Peptides |
| α-CGRP (mouse, rat) (TFA)是一种神经肽 (降钙素基因相关肽)，可用于心血管、促炎和代谢相关的研究。 序列：SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2 (Disulfide bridge:Cys2-Cys7) | |||
| M20597 | PF-562271 HCl | PF-562271 HCl | FAK |
| PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1. | |||
| M20599 | PI-1840 | PI-1840 | Proteasome |
| PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor with IC50 of 27 nM with little effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L). | |||
| M20605
|
CFI-400945 | CFI-400945 | PLK |
| CFI-400945 is an orally active, potent and selective polo-like kinase 4(PLK4) inhibitor with Ki value of 0.26 nM. | |||
| M20614 | NSC-87877 disodium salt | NSC-87877 disodium salt | Phosphatase |
| NSC-87877 disodium is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. NSC-87877 disodium salt also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation. | |||
| M20632 | Selective PI3Kδ Inhibitor 1 (compound 7n) | Selective PI3Kδ Inhibitor 1 (compound 7n) | PI3K |
| Selective PI3Kδ Inhibitor 1 (compound 7n) is an inhibitor of PI3Kδ with an IC50 of 0.9 nM and >1000-fold selectivity against other class I PI3K isoforms [PI3K α/γ/β=3670/1460/21300 nM]. | |||
| M20635 | DCC-2618 | DCC-2618 | c-Kit |
| DCC-2618 is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of KIT and PDGFR with potential antineoplastic activity. It also inhibits several other kinases, including VEGFR2, TIE2, PDGFR-beta and CSF1R, thereby further inhibiting tumor cell growth. | |||
| M20668 | Trifluoperazine | Trifluoperazine | Dopamine Receptor |
| NSC-17474, RP-7623, SKF-5019 | |||
| Trifluoperazine is an FDA-approved antipsychotic drug for schizophrenia. It is an inhibitor of calmodulin (CaM) and Dopamine D2 receptor with an IC50 value of 1.2 nM for D2 receptor. | |||
| M20692
|
G150 | G150 | Others |
| G150 is a potent and highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with IC50 of 10.2 nM. | |||
| M20704 | SR18662 | SR18662 | Others |
| SR18662 is an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM. SR18662 reduces the viability of multiple colorectal cancer cell lines. SR18662 induces apoptosis. | |||
| M20706 | HQNO | HQNO | Others |
| 2-heptyl-4-hydroxyquinoline-N-oxide | |||
| HQNO is a natural quinolone secreted by P. aeruginosa. HQNO is a potent inhibitor of the electron transport chain with Kd of 64 nM for the ubiquinol-ferricytochrome c oxidoreductase segment (Complex III) of the respiratory chain. HQNO is also an inhibitor of bacterial and mitochondrialType II NADH : quinone oxidoreductase (NDH-2) with IC50 of 7.3 μM in the presence of 50μM menadione. | |||
| M20739 | TRi-1 | TRi-1 | Others |
| HUN20688, TXNRD1 inhibitor 1 | |||
| TRi-1 (HUN20688, TXNRD1 inhibitor 1) is a potent, specific and irreversible cytosolic thioredoxin reductase 1 (TXNRD1) inhibitor with IC50 of 12 nM. TRi-1 exhibits anti-cancer activity while having little mitochondrial toxicity. | |||
