找到约 30 条 “Con B-1” 相关结果 （用时 0.09 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
| M21110 | Con B-1 | Con B-1 | ALK |
| ConB-1是一种对正常细胞低毒的强选择性 ALK 抑制剂。 | |||
M2892
|
NSC697923 | NSC697923 | E1/E2/E3 Enzyme |
| NSC697923 是一种细胞选择透过性 Ub-conjugating enzyme (E2) 复合Ubc13-Uev1A 抑制剂. | |||
M3621
|
Ionomycin | 离子霉素(乙醇溶液) | Calcium Channel |
| SQ23377 | |||
| 离子霉素（Ionomycin），一种来源于Streptomyces conglobatus的聚醚类窄谱抗生素，有效作用于G+菌。常用作一种有效的钙离子载体，高度选择性结合钙离子（Ca2+＞Mg2+＞＞Sr2+=Ba2+）。离子霉素（Ionomycin）常与PMA联用以刺激淋巴细胞。本品为离子霉素的乙醇溶液形式，浓度为10mg/ml，每只体积100ul，含离子霉素1mg。 | |||
| M4014
|
Licochalcone-C | 甘草查尔酮C | Glucosidase |
| Lico-C | |||
| Licochalcone C 能够抑制 α-葡萄糖苷酶 (α-glucosidase)，其对 α-葡萄糖苷酶和蛋白酪氨酸磷酸酶 1B 的 IC50 值分别为 <100 nM 和 92.43 μM。Licochalcone-C是一种脂多糖-干扰素-γ炎症的抑制剂。 | |||
| M7377 | TC-MCH 7c | TC-MCH 7c | Others |
| TC-MCH 7c is a selective melanin-concentrating hormone receptor 1 (MCH 1R) antagonist. | |||
| M8283 | Pleconaril | 普可那利 | Others |
| VP 63843; Win 63843 | |||
| Pleconaril is an orally bioavailable, broad-spectrum antipicorna-viral agent that binds to hydrophobic pocket in VP1 major capsid protein. | |||
| M8467 | OF-1 | OF-1 | Others |
| OF-1 is a chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) family of scaffolding proteins (BRPF1, BRPF2, BRPF3) that assemble histone acetyltransferase (HAT) complexes of the MYST family members MOZ and MORF. | |||
| M58448
|
Recombinant Human ALDH1A1 (E.coli, N-6His) | 重组人ALDH1A1 (E.coli, N-6His) | Cytokines and Growth Factors |
| Aldehyde Dehydrogenase Family 1 Member A1 | |||
| Aldehyde Dehydrogenase Family 1 Member A1 (ALDH1A1) is a cytoplasmic enzyme that belongs to the Aldehyde Dehydrogenase family. ALDH1A1 is the second enzyme of the major oxidative pathway of alcohol metabolism. ALDH1A1 binds free retinal and cellular retinol-binding protein-bound retinal. It can convert/oxidize retinaldehyde to retinoic acid. | |||
| M8601 | R-Ketorolac | 酮咯酸R-异构体 | Others |
| R-Ketorolac is potent and selective Rho-family GTPases Cdc42 (cell division control protein 42) and Rac1 (Ras-related C3 botulinum toxin substrate 1) allosteric inhibitor. | |||
| M10686
|
Muscone | 麝香酮 | IL Receptor/Related |
| Muscone 是中药麝香的主要活性单体。Muscone 抑制 NF-κB 和 NLRP3 炎性小体的活化。Muscone 显着降低炎性细胞因子 (IL-1β，TNF-α 和 IL-6) 水平，并最终改善心脏功能和存活率。 | |||
| M14861
|
Thalidomide-O-amido-C8-NH2 TFA | Thalidomide-O-amido-C8-NH2 TFA | PROTAC |
| Cereblon Ligand -Linker Conjugates 2 TFA; E3 Ligase Ligand-Linker Conjugates 20 TFA | |||
| Thalidomide-O-amido-C8-NH2 TFA (Cereblon Ligand -Linker Conjugates 2 TFA) 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 1 个 linker。 | |||
| M20389 | Quisinostat (JNJ-26481585) 2HCl | Quisinostat (JNJ-26481585) 2HCl | HDAC |
| Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11 greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2. | |||
| M20515 | Emedastine | Emedastine | Histamine Receptor |
| Emedastine is a potent, high affinity histamine H1-receptor-selective antagonist with Ki of 1.3 ±0.1 nM for H1-receptors while considerably weaker at H2- (K1 = 49,067 ± 11,113 nM) and H3-receptors (Ki = 12,430 ± 1,282 nM). | |||
| M20619 | CeMMEC1 HCl | CeMMEC1 HCl | DNA/RNA Synthesis |
| CeMMEC1 is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (IC50=0.9 μM). | |||
| M20635 | DCC-2618 | DCC-2618 | c-Kit |
| DCC-2618 is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of KIT and PDGFR with potential antineoplastic activity. It also inhibits several other kinases, including VEGFR2, TIE2, PDGFR-beta and CSF1R, thereby further inhibiting tumor cell growth. | |||
| M20752 | PZ-2891 | PZ-2891 | Others |
| PZ-2891 is a selective, orally active and brain-penetrant pantothenate kinase (PANK) modulator that acts as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits PANK with IC50 of 40.2 nM, 0.7 nM and 1.3 nM for hPANK1β, hPANK2, and hPANK3, respectively. | |||
| M20783 | Tenofovir alafenamide hemifumarate | Tenofovir alafenamide hemifumarate | Reverse Transcriptase |
| TAF hemifumarate, GS-7340 hemifumarate | |||
| Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection. | |||
| M21278
|
Recombinant Mouse IL-12 (HEK293) | 重组小鼠IL-12 蛋白 (HEK293) | Cytokines and Growth Factors |
| IL12; NKSF; TCMF; CLMF; TSF | |||
| Interleukin-12 (IL-12), also known as NKSF, TCMF, CLMF and TSF, is a heterodimeric cytokine consisting of p35 and p40 subunits. IL‑12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. | |||
| M21331
|
Recombinant Human CDH1 (HEK293, C-6His) | 重组人CDH1 蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
| Cadherin-1; CDH1;CAM 120/80;E-cadherin; CD324 | |||
| Recombinant human Cadherin-1/E-Cadherin/CDH1 is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. Accession: P12830. | |||
| M25270 | Conatumumab | Conatumumab | TNF Receptor |
| AMG 655; TRAIL-R2 mAb Human Anti-TNFRSF10B Recombinant Antibody | |||
| Conatumumab (AMG 655) 是一种针对人死亡受体 5 (DR5，TRAILR2) 的单克隆激动剂抗体(Kd: 长型 DR5 为 1 nM, 短型 DR5 为 0.8 nM)。Conatumumab 通过激活 caspase 诱导细胞凋亡 (Apoptosis)。Conatumumab 可用于癌症研究。 | |||
| M25346
|
Human IgG4, kappa Isotype Control Antibody | Human IgG4, kappa Isotype Control Antibody | Others |
| Human IgG4, kappa Isotype Control Antibody (HyHEL-10) | |||
| M25383
|
Recombinant Human KEAP1 Protein (Baculovirus-Insect) | 重组人KEAP1蛋白 (Baculovirus-Insect) | Cytokines and Growth Factors |
| Kelch-like ECH-associated protein 1; INRF2 | |||
| Kelch-like ECH-associated protein 1 (KEAP1) is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB (POZ) domain, and six Kelch repeats. KEAP1 is a key regulator of the NRF2 transcription factor, which transactivates the antioxidant response element (ARE) and upregulates numerous proteins involved in antioxidant defense. | |||
| M25384
|
Recombinant Human KEAP1 Protein (Baculovirus-Insect, His & GST Tag) | 重组人KEAP1蛋白 (Baculovirus-Insect, His & GST Tag) | Cytokines and Growth Factors |
| Kelch-like ECH-associated protein 1; INRF2 | |||
| Kelch-like ECH-associated protein 1 (KEAP1) is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB (POZ) domain, and six Kelch repeats. KEAP1 is a key regulator of the NRF2 transcription factor, which transactivates the antioxidant response element (ARE) and upregulates numerous proteins involved in antioxidant defense. | |||
| M25427
|
Recombinant Human SDF-1 Protein (E. coli) | 重组人SDF-1蛋白 (E. coli) | Cytokines and Growth Factors |
| Stromal cell-derived factor-1 | |||
| The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF-1 binds primarily to CXC receptor 4 (CXCR4; CD184). The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription. | |||
| M25441
|
Recombinant Human Endothelin B Receptor Protein (HEK293, His Tag) | 重组人EDNRB蛋白 (HEK293, His Tag) | Cytokines and Growth Factors |
| human EDNRB | |||
| EDNRB is a new candidate tumor suppressor gene which is often down-regulated or even silenced by promoter hypermethylation in various human cancers. The recombinant human EDNRB consists 86 amino acids and predicts a molecular mass of 9.5 kDa. A DNA sequence encoding the human EDNRB (NP_000106.1) (Met1-Lys101) was expressed with a polyhistidine tag at the C-terminus. | |||
| M25536
|
Recombinant Human CXCL13/BCA-1 (E. coli) | 重组人CXCL13/BCA-1蛋白 (E. coli) | Cytokines and Growth Factors |
| CXC chemokine BLC; Small-inducible cytokine B13 | |||
| CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Recombinant human CXCL13 is a single non-glycosylated polypeptide chain containing 87 amino acids and mature human BCA-1 shares 64 % amino acid sequence similarity with the murine protein and 23–34 % amino acid sequence identity with other known CXC chemokines. Determined by a chemotaxis bioassay using human B cells, the biological activity is in a concentration range of 1.0-10 ng/ml. | |||
| M25585
|
Recombinant Human HMGB1 Protein (HEK293, C-6His) | 重组人HMGB1蛋白 (HEK293, C-6His) | Other Proteins |
| High Mobility Group Protein B1 | |||
| High mobility group protein B1 is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. | |||
| M25587
|
Recombinant Mouse CXCL13/BCA-1 Protein (HEK293, N-Fc) | 重组小鼠CXCL13/BCA-1蛋白 (HEK293, N-Fc) | Cytokines and Growth Factors |
| CXCL13 is a homeostatic chemokine, and is constitutively secreted by stromal cells in B-cell areas of secondary lymphoid tissues (follicles). Recombinant Mouse CXCL13/BCA-1 Protein is produced by HEK293 expression system with a N-Terminal Fc-tag. | |||
| M55397
|
Recombinant Human HMGB1 Protein (E. coli) | 重组人HMGB1 蛋白 (E. coli) | Other Proteins |
| High Mobility Group Protein B1 | |||
| High mobility group protein B1 is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. As a nuclear protein, HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile, it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte, T cell, dendritic cell activities in inflammatory responses. | |||
| M28934 | Ravuconazole | 雷夫康唑 | Antifungal |
| BMS-207147; ER-30346 | |||
| Ravuconazole (BMS-207147;ER-30346) 是一种口服的三唑抗真菌活性分子，能够有效广谱的抑制真菌。 | |||
