The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF-1 binds primarily to CXC receptor 4 (CXCR4; CD184). The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription.
别名：Stromal cell-derived factor-1
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF-1 binds primarily to CXC receptor 4 (CXCR4; CD184). The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription. SDF-1/CXCL12 has crucial roles in the formation of multiple organ systems during embryogenesis and in the regulation of bone marrow haematopoiesis and immune function in the postnatal organism.
Recombinant Human SDF-1 is produced by E.coli expression system and the target gene encoding Lys 22-Met 93 is expressed.
The recombinant human SDF-1 consists of 73 amino acids and predicts a molecular mass of 8.6 kDa. It migrates as an approximately 12 kDa band in SDS-PAGE under reducing conditions.
Accession: P48061
Endotoxin: < 1.0 EU per μg protein as determined by LAL test
Lyophilized from sterile PBS, pH 7.4.
| 溶解性（25°C） | Reconstitute the lyophilized powder in ddH2O or PBS to 100 μg/ml. |
| 储存条件 | Stable for up to twelve months from date of receipt at -20℃ to -80℃ |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
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