Recombinant Human HMGB1 Protein (HEK293, C-6His) 别名：High Mobility Group Protein B1; 重组人HMGB1蛋白 (HEK293, C-6His)
High mobility group protein B1 is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival.
化学性质/溶解性/储存
| 性状 | Solution |
| 中文名称 | 重组人HMGB1蛋白 (HEK293, C-6His) |
| 储存条件 | Store at ≤ -70°C, stable for 6 months after receipt. |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
生物活性
High mobility group protein B1 is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile, it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte, T cell, dendritic cell activities in inflammatory responses.
Recombinant Human High Mobility Group Protein B1 expressed the target gene encoding Gly2-Glu215 with a 6His tag at the C-terminus.
Accession: P09429
APMol Mass: 25-30 KDa, reducing conditions
Endotoxin <1 EU/µg
Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.
This product is shipped on dry ice, store it immediately at the temperature listed below upon receipt.
实验参考
建议您制定动物给药及实验方案时，尽量参考已发表的相关实验文献（溶剂种类及配比众多，简单地溶解目的化合物，并不能解决动物给药依从性、体内生物利用度、组织分布等相关问题，未必能保证目的化合物在动物体内充分发挥生物学效用）。
体内实验的工作液，建议您现用现配，当天使用；如在配制过程中出现沉淀、析出现象，可以通过超声和（或）加热的方式助溶。
切勿一次性将产品全部溶解。
请在下面的计算器中，输入您的动物实验相关数据并点击计算，即可得到该实验的总需药量和工作液终浓度。
例如您给药剂量是10 mg/kg，平均每只动物的体重为20 g，每只动物的给药体积是100 μL，动物数量为20只，则该动物实验的总需药量为4 mg，工作液终浓度为2 mg/mL。
1：鉴于实验过程的损耗，建议您至少多配1-2只动物的量；
2：为该产品最终给药时的浓度。
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