M58217
|
Recombinant CRM197 (Nontoxic Diphtheria Toxin, E. coli) |
CRM197 是白喉毒素（Diphtheria toxin）的一种非毒性突变体。与天然白喉毒素不同，CRM197 因将第52位氨基酸从甘氨酸（Glycine）突变为谷氨酸（Glutamate），从而失去了毒性，但仍然保留了其免疫原性和与细胞受体结合的能力。作为一种载体蛋白，CRM197能够与多糖抗原结合，增强其免疫原性，并将多糖抗原从T细胞非依赖性转化为T细胞依赖性抗原，激发更强烈的免疫反应，从而提高疫苗的免疫效果。本产品为从大肠杆菌中表达的完全可溶性的 CRM197 蛋白。本产品不适用于白喉毒素受体 (Diphtheria toxin receptor, DTR) 小鼠实验。 |
| M66231
|
Recombinant Human UCP2 Protein (E. coli, N-His) |
线粒体解耦蛋白（UCP）将ATP合成中的氧化磷酸化分离，UCP促进阴离子从内层线粒体膜向外层转移，以及质子从外层向内层线粒体膜的回转。它们还降低哺乳动物细胞中的线粒体膜电位。 |
| M66186
|
Recombinant Human S100A8 & S100A9 Protein (Baculovirus-Insect, C-His & C-Flag) |
Calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. It contributes to leukocyte function, regulates the cytoskeleton, and activates intracellular NADPH oxidase. It is produced by neutrophils and monocytes, and forms Ca2+-dependent heterodimer/heterotetramer complexes (termed calprotectin) with S100A9. |
| M59321
|
Recombinant Human COL6A3 Protein (HEK293) |
COL6A3蛋白是VI型胶原蛋白的重要组成部分，具有细胞结合蛋白的功能。COL6A3蛋白主要参与细胞外基质的构建，与肌肉组织的结构和功能相关。 |
| M59315
|
Recombinant Human SAA2 Protein (E. coli, N-6His) |
Serum amyloid A-2 protein (SAA2) belongs to the SAA family. SAA2 functions as major acute phase reactant and could works as apolipoprotein of the HDL complex. |
| M59111
|
Recombinant Human S100P (E. coli, N-6His) |
S100P 蛋白是一种多功能钙传感器，积极促进细胞钙信号传导。它以钙依赖性方式与 EZR 和 PPP5C 等蛋白质相互作用，间接影响微绒毛形成等过程。S100P 可以通过自分泌激活活化糖基化终产物 (RAGE) 受体来刺激细胞增殖。S100P 作为同二聚体存在并与 S100A1 形成异二聚体，也与 S100PBP 和 S100Z 相互作用，并以钙依赖性方式与 CACYBP 结合。 |
| M59083
|
Recombinant Human GSDMD Protein (E. coli, N-His) |
GSDMD (Gasdermin D) is a protein that plays a crucial role in pyroptosis, a highly inflammatory form of cell death. It acts as a pore-forming protein, creating openings in the cell membrane and triggering the release of inflammatory molecules like interleukin-1β. |
| M59064
|
Recombinant Human TSPAN13 Protein (E. coli, C-His) |
Recombinant Human TSPAN13 Protein expressed the target gene encoding Cys94-Glu164 with a polyhistidine tag at the C-terminus. |
| M59059
|
Recombinant Human SAA1 Protein (E. coli, N-6His) |
Serum Amyloid A1 Protein (SAA1) is an acute phase apolipoprotein reactant that is produced predominantly by hepatocytes and is under the regulation of inflammatory cytokines. SAA may play a role in the immune system and facilitate the repair of injured tissues, it also acts as an antibacterial agent, and signals the migration of germ-fighting cells to sites of infection. |
| M59008
|
Recombinant Human IMPDH2 Protein (E. coli, N-His) |
Recombinant Human IMPDH2 Protein (E. coli, N-His) expressed the target gene encoding Asp226-Phe514 with a His tag at the N-terminus. |
| M58950
|
Recombinant Human Semaphorin 5A (HEK293, C-6His) |
Semaphorin-5A (SEMA5A) is a member of the Semaphorin family of axon guidance molecules. SEMA5A mutations have been implicated in the genetic syndrome,cri-du-chat,while some polymorphisms may increase risk for neurodegenerative diseases such as Parkinson. The expression of SEMA5A may be upregulated in metastatic cancer cells and downregulated in autism. |
| M58942
|
Recombinant Human TRIM21 Protein (E. coli, N-His) |
TRIM21 Protein, an E3 ubiquitin ligase, plays a vital role in the immune response by targeting intracellular pathogens for degradation. It is involved in the recognition and clearance of viral particles. E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. |
| M58628
|
Recombinant Mouse Progranulin Protein (HEK293, C-His) |
颗粒体蛋白前体 (PGRN) 蛋白调节溶酶体功能，影响蛋白质转运、酶活性和酸化。它通过组织蛋白酶 B 降解成熟的组织蛋白酶 D。颗粒体蛋白前体 (PGRN) 蛋白是溶酶体功能的重要调节剂和生长因子，其作用涵盖炎症、伤口愈合和细胞增殖。PGRN 还充当伤口愈合中的生长因子，直接影响真皮成纤维细胞和内皮细胞细胞，促进细胞分裂、迁移和毛细血管样小管结构的形成。它通过阻止 TNF 介导的中性粒细胞活化、防止氧化剂和蛋白酶的释放，进一步促进上皮细胞增殖。 |
| M58626
|
Recombinant Human ERK5 Protein (Baculovirus-Insect, Full Length, N-GST) |
Recombinant Human ERK5 Protein (Baculovirus-Insect, Full Length, N-GST) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_139033. |
| M55397
|
Recombinant Human HMGB1 Protein (E. coli) |
High mobility group protein B1 is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. As a nuclear protein, HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile, it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte, T cell, dendritic cell activities in inflammatory responses. |
| M55380
|
Recombinant Human SEMA3A (HEK293, N-6His-Flag) |
Semaphorin 3A (SEMA3A) is a secreted protein which belongs to the semaphorin family. Semaphorin 3A can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. |
| M40767
|
Recombinant Mouse MFGE8 Protein (HEK293, C-6×His) |
Mouse MFGE8 Protein contributes to phagocytic removal of apoptotic cells in many tissues. It plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. |
| M40758
|
Recombinant Human MFGE8 Protein (Baculovirus-Insect, His-AVI, Biotinylated) |
MFG-E8 is expressed in mammary epithelial cell surfaces and aortic media. MFG-E8 has opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells. It also mediates the engulfment of the dead cell. |
| M25585
|
Recombinant Human HMGB1 Protein (HEK293, C-6His) |
High mobility group protein B1 is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. |
| M22497
|
Recombinant Human HMGB1 Protein (E. coli, C-His) |
重组人高迁移率族蛋白 1 (HMGB1)，也称为 HMG-1 或两性蛋白，是非组蛋白染色体蛋白的高迁移率族蛋白家族的成员。人 HMGB1 表达为包含三个结构域的 30 kDa、215 个氨基酸 (aa) 的单链多肽。 |
