M58217
|
Recombinant CRM197 (Nontoxic Diphtheria Toxin, E. coli) |
CRM197 是白喉毒素（Diphtheria toxin）的一种非毒性突变体。与天然白喉毒素不同，CRM197 因将第52位氨基酸从甘氨酸（Glycine）突变为谷氨酸（Glutamate），从而失去了毒性，但仍然保留了其免疫原性和与细胞受体结合的能力。作为一种载体蛋白，CRM197能够与多糖抗原结合，增强其免疫原性，并将多糖抗原从T细胞非依赖性转化为T细胞依赖性抗原，激发更强烈的免疫反应，从而提高疫苗的免疫效果。本产品为从大肠杆菌中表达的完全可溶性的 CRM197 蛋白。本产品不适用于白喉毒素受体 (Diphtheria toxin receptor, DTR) 小鼠实验。 |
| M58628
|
Recombinant Mouse Progranulin Protein (HEK293, C-His) |
颗粒体蛋白前体 (PGRN) 蛋白调节溶酶体功能，影响蛋白质转运、酶活性和酸化。它通过组织蛋白酶 B 降解成熟的组织蛋白酶 D。颗粒体蛋白前体 (PGRN) 蛋白是溶酶体功能的重要调节剂和生长因子，其作用涵盖炎症、伤口愈合和细胞增殖。PGRN 还充当伤口愈合中的生长因子，直接影响真皮成纤维细胞和内皮细胞细胞，促进细胞分裂、迁移和毛细血管样小管结构的形成。它通过阻止 TNF 介导的中性粒细胞活化、防止氧化剂和蛋白酶的释放，进一步促进上皮细胞增殖。 |
| M58626
|
Recombinant Human ERK5 Protein (Baculovirus-Insect, Full Length, N-GST) |
Recombinant Human ERK5 Protein (Baculovirus-Insect, Full Length, N-GST) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_139033. |
| M55397
|
Recombinant Human HMGB1 Protein (E. coli) |
High mobility group protein B1 is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. As a nuclear protein, HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile, it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte, T cell, dendritic cell activities in inflammatory responses. |
| M40767
|
Recombinant Mouse MFGE8 Protein (HEK293, C-6×His) |
Mouse MFGE8 Protein contributes to phagocytic removal of apoptotic cells in many tissues. It plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. |
| M40758
|
Recombinant Human MFGE8 Protein (Baculovirus-Insect, His-AVI, Biotinylated) |
MFG-E8 is expressed in mammary epithelial cell surfaces and aortic media. MFG-E8 has opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells. It also mediates the engulfment of the dead cell. |
| M25585
|
Recombinant Human HMGB1 Protein (HEK293, C-6His) |
High mobility group protein B1 is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. |
| M22497
|
Recombinant Human HMGB1 Protein (E. coli, C-His) |
重组人高迁移率族蛋白 1 (HMGB1)，也称为 HMG-1 或两性蛋白，是非组蛋白染色体蛋白的高迁移率族蛋白家族的成员。人 HMGB1 表达为包含三个结构域的 30 kDa、215 个氨基酸 (aa) 的单链多肽。 |
| M22496
|
Recombinant Mouse HMGB1 Protein (E. coli, C-His) |
重组小鼠HMGB1蛋白 是二硫键连接的同型二聚体。高迁移率族蛋白 1 (HMGB1)，也称为 HMG-1，是 HMGB 家族的成员。HMGB1 是一种 DNA 结合核蛋白，在细胞因子刺激后主动释放，在细胞死亡期间被动释放。 |
