找到约 8 条 “Checkpoint” 相关结果 （用时 0.11 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M1676
|
BIBR1532 | BIBR1532 | Checkpoint |
| BIBR-1532 | |||
| BIBR 1532是一种有效的，选择性的，非竞争性的端粒酶 telomerase 抑制剂，IC50为100 nM，也可通过抑制ATM/CHK1（ataxia-telangiectasia-mutated/Checkpoint kinase 1）通路发挥作用。BIBR1532 也是TERT抑制剂，TERT是端粒酶活性调节的限速酶。 | |||
M6104
|
Ipilimumab | 伊匹木单抗；伊匹单抗 | Checkpoint |
| MDX-010, BMS-734016；Yervoy | |||
| Ipilimumab (MDX-010, BMS-734016，伊匹单抗)是一种全人源化的抗CTL antigen 4 (CTLA-4)的单克隆抗体，Ipilimumab是一种免疫检查点（Checkpoint）抑制剂。 | |||
| M7986 | OM137 | OM137 | Others |
| OM137 is an inhibitor of aurora kinases; inhibitor of spindle checkpoint. | |||
| M10129
|
CCT245737 | CCT245737 | Checkpoint |
| SRA737; PNT-737 | |||
| CCT245737是一种有效的，选择性的和口服活性的检查点激酶1（checkpoint kinase 1）抑制剂，对CHK1，CHK2和G2 check point abrogation 的IC50值分别为1.3 nM，2440 nM 和 30 nM。 | |||
| M21002 | BOS172722 | BOS172722 | Others |
| BOS172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM, Ki of 0.11 nM. | |||
| M30540 | Chk2-IN-1 | Chk2-IN-1 | Checkpoint |
| Chk2-IN-1 (compound 1) 是一种有效和选择性的 checkpoint kinase 2 (Chk2) 抑制剂，抑制 Chk2 和 Chk1 的 IC50 值分别为 13.5 nM 和 220.4 nM。Chk2-IN-1 可引发强烈的共济失调毛细血管扩张突变 (ATM) 依赖性 Chk2 介导的辐射防护作用。 | |||
| M40256 | Cryptomoscatone D2 | Cryptomoscatone D2 | Others |
| Cryptomoscatone D2 是一种有效的 G2 检查点 (G2 checkpoint) 抑制剂。 | |||
| M58881
|
Recombinant Human CHK1 (BV) | 重组人CHK1 (BV) | Target Proteins |
| Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA | |||
