找到约 32 条 “CY5-SE” 相关结果 （用时 0.105 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M10195
|
MOG (35-55) (Mouse, rat) | 髓鞘少突胶质细胞糖蛋白 | Animal Modeling |
| Myelin Oligodendrocyte Glycoprotein (35-55) (Mouse, rat) | |||
| MOG (35-55) (Mouse, rat)（髓鞘少突胶质细胞糖蛋白）是中枢神经鞘的一个次要成分，能诱导强效的T细胞和B细胞反应。可用于构建实验性自身免疫脑脊髓炎(EAE)模型。 | |||
| M13775
|
CY5-SE | CY5-SE | Fluorescent Dye |
| Cy5 NHS Ester; Sulfo-Cyanine5 Succinimidyl Ester | |||
| Cy5-SE (Cy5 NHS Ester) 是一种用于标记肽, 蛋白质, 寡核苷酸的氨基基团的反应染料。 激发波长 (nm): 649, 发射波长 (nm): 670。 | |||
| M13776
|
CY5-SE triethylamine salt | CY5-SE triethylamine salt | Fluorescent Dye |
| Cy5 NHS Ester triethylamine salt; Sulfo-Cyanine5 Succinimidyl Ester triethylamine salt | |||
| Cy5-SE (Cy5 NHS Ester) triethylamine salt 一种用于标记肽, 蛋白质, 寡核苷酸的氨基基团的反应染料 (Ex=649 nm; Em=670 nm)。 | |||
| M14818
|
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA | Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA | Peptides |
| MOG (35-55) (TFA) | |||
| Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (TFA) 是中枢神经鞘的一个次要成分。Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (TFA)引发复发缓解性神经系统疾病，伴有广泛的斑块样脱髓鞘。还能诱导强效的 T细胞和 B 细胞反应，同时是高度脑源性的。 | |||
| M31324 | Cy5 DiSE(Di SO3) | Cy5 DiSE(Di SO3) | Fluorescent Dye |
| Cy5 DiSE(Di SO3)是一种常用的荧光染料。 | |||
| M31330
|
Cy5.5-SE | Cy5.5-SE | Fluorescent Dye |
| Cyanine5.5 NHS ester | |||
| Cy5.5-SE（Cyanine5.5 NHS ester）是一种花菁染料，可用于标记肽、蛋白质和寡聚体等生物分子和动物活体成像。 | |||
| M51434 | Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse | Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse | Others |
| Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse (MOG (40-54)) 是髓鞘少突胶质细胞糖蛋白 (MOG) 蛋白的 CD8 相关自身抗原表位，与 H-2Db 相关。 | |||
| M52647 | Cytochrome P450 reductase | Cytochrome P450 reductase | Cytochrome P450 (e.g. CYP17) |
| Cytochrome P450 reductase 是一种 NADPH-细胞色素还原酶。 | |||
| M54197 | Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat | Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat | Animal Modeling |
| Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) 是中枢神经鞘的一个次要成分。 | |||
| M2788
|
JZL184 | JZL184 | MAGL |
| JZL184是第一个选择性的Monoacylglycerol lipase (MAGL)（单酰基甘油脂肪酶）抑制剂，IC50为8 nM。JZL184还可调控Amidase家族中的FAAH-4，具有极好的选择性。 | |||
| M4987
|
Procyanidin B4 | Procyanidin B4 | Others |
| A series of dimeric procyanidins (1-9) and some related polyphenols (10-15) were chosen as model compounds in a comparative investigation for various biological activities in order to obtain structure-activity relationships. | |||
| M6642 | CYM 50260 | CYM 50260 | S1P Receptor |
| CYM 50260 is a potent and selective S1P4 agonist. | |||
| M6643
|
CYM 5520 | CYM 5520 | S1P Receptor |
| CYM 5520 is a selective S1P2 allosteric agonist. | |||
| M7763
|
Diacylglycerol Kinase Inhibitor I | Diacylglycerol Kinase Inhibitor I | 5-HT Receptor |
| R 59-022; DKGI-I | |||
| Diacylglycerol Kinase Inhibitor I（R 59-022）是一种二酰甘油激酶（DGK）和5-HT Receptor的抑制剂，作用于DGK的IC50值为2.8 µM，并能抑制 OAG 磷酸化为 OAPA。此外，Diacylglycerol Kinase Inhibitor I也能激活蛋白激酶 C (PKC)。 | |||
| M7804 | 5-Fluoro-2′-deoxycytidine | 5-Fluoro-2′-deoxycytidine | Others |
| 5-Fluoro-2′-deoxycytidine is a mechanism based DNMT (DNA cytosine-5 methyltransferase) inhibitor, that forms a covalent link with the cysteine residue in the active site of DNMT. | |||
| M8431
|
CYM50358 | CYM50358 | S1P Receptor |
| CYM50358 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). | |||
| M8767 | MIND4-17 | MIND4-17 | Others |
| MIND4-17 is a potent NRF2 (nuclear factor erythroid 2-related factor 2) activator that covalently modifies a critical stress-sensor cysteine (C151) in the BTB domain of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEAP1). | |||
| M8796 | TCPOBOP | TCPOBOP | Others |
| TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct agonist of CAR. | |||
| M10499
|
FPL 62064 | FPL 62064 | Lipoxygenase |
| FPL62064 | |||
| FPL 62064 是一种有效的 5-lipoxygenase (5-LOX) 和 prostaglandin synthetase (cyclooxygenase, COX) 的双重抑制剂，它对RBL-1 胞质 5-脂氧合酶和前列腺素合成酶prostaglandin synthetase的IC50值分别为3.5 μM和3.1 μM。 | |||
| M14561
|
Recombinant Human MIP-5/CCL15 Protein (E. coli, aa 22-113, C-His) | 重组人MIP-5/CCL15蛋白 (E. coli, aa 22-113, C-His) | Recombinant Proteins |
| SCYA15; HCC-2; NCC-3 | |||
| Chemokine ligand 15 (CCL15), also known as leukotactin-1, MIP5, MIP1 and HCC-2, is a small cytokine belonging to the C-C chemokine family. CCL15 is prevantly expressed in liver, small intestine, colon, and in certain leukocytes and macrophages of the lung. | |||
| M20389 | Quisinostat (JNJ-26481585) 2HCl | Quisinostat (JNJ-26481585) 2HCl | HDAC |
| Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11 greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2. | |||
| M20477 | 7-Hydroxyflavone | 7-Hydroxyflavone | Cytochrome P450 (e.g. CYP17) |
| 7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2. It also has excellent antioxidant properties and great potential to be applied as medicines. | |||
| M20671 | SGC-GAK-1 | SGC-GAK-1 | CDK |
| SGC-GAK-1 is a potent, selective, and cell-active inhibitor of cyclin G-associated kinase (GAK) with Ki value of 3.1 nM and >50-fold selectivity over nearest kinase. | |||
| M20697 | Triglycidyl Isocyanurate (Teroxirone) | Triglycidyl Isocyanurate (Teroxirone) | p53 |
| Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC | |||
| Triglycidyl Isocyanurate, also known as Teroxirone, is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry. | |||
| M20706 | HQNO | HQNO | Others |
| 2-heptyl-4-hydroxyquinoline-N-oxide | |||
| HQNO is a natural quinolone secreted by P. aeruginosa. HQNO is a potent inhibitor of the electron transport chain with Kd of 64 nM for the ubiquinol-ferricytochrome c oxidoreductase segment (Complex III) of the respiratory chain. HQNO is also an inhibitor of bacterial and mitochondrialType II NADH : quinone oxidoreductase (NDH-2) with IC50 of 7.3 μM in the presence of 50μM menadione. | |||
| M27921 | BI 653048 | BI 653048 | GCR |
| BI 653048 是一种选择性且口服的非甾体类糖皮质激素 (glucocorticoid (GC)) 激动剂，其 IC50 值为 55 nM。BI 653048 抑制 CP1A2，CYP2D6，CYP2C9，CYP2C19 和 CYP3A4 的活性并降低对 hERG 离子通道的亲和力 (IC50>30 μM)。BI 653048 也是一种 HCV NS3 protease 抑制剂，可以减少感染丙型肝炎病毒的病毒载量。 | |||
| M27922 | BI 653048 phosphate | BI 653048 phosphate | GCR |
| BI 653048 phosphate 是一种选择性且口服的非甾体类糖皮质激素 (glucocorticoid (GC)) 激动剂，其 IC50 值为 55 nM。BI 653048 phosphate 抑制 CP1A2，CYP2D6，CYP2C9，CYP2C19 和 CYP3A4 的活性并降低对 hERG 离子通道的亲和力 (IC50>30 μM)。BI 653048 phosphate 也是一种 HCV NS3 protease 抑制剂。 | |||
| M28670 | Seviteronel | Seviteronel | Cytochrome P450 (e.g. CYP17) |
| VT-464 | |||
| Seviteronel (VT-464) 是 CYP17 裂解酶抑制剂，对h-Lyase的 IC50 为 69 nM。此外，Seviteronel 还是雄激素受体（AR）拮抗剂，可用于前列腺癌的相关研究。 | |||
| M28685 | Cholesterol 24-hydroxylase-IN-1 | Cholesterol 24-hydroxylase-IN-1 | Cytochrome P450 (e.g. CYP17) |
| Cholesterol 24-hydroxylase-IN-1 (compound 17) 是一种强效、口服活性和高选择性的胆固醇24-羟化酶 (CH24H or CYP46A1) 抑制剂 (IC50=8.5 nM)。Cholesterol 24-hydroxylase-IN-1 能透过血脑屏障。 | |||
| M29846 | α-Hydroxyglutaric acid | α-Hydroxyglutaric acid | Histone demethylase |
| 2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid | |||
| α-Hydroxyglutaric acid (2-Hydroxyglutarate) 是戊二酸的 α-羟基酸形式。α-Hydroxyglutaric acid 是多种 α-酮戊二酸依赖性双加氧酶 (包括 histone demethylases 和 5-甲基胞嘧啶羟化酶 (5-methlycytosine (5mC) hydroxylases) 的 TET 家族) 的竞争性抑制剂。 | |||
| M30059 | α-Hydroxyglutaric acid disodium | α-Hydroxyglutaric acid disodium | Histone demethylase |
| 2-Hydroxyglutarate disodium; 2-Hydroxyglutaric acid disodium; 2-Hydroxypentanedioic acid disodium | |||
| α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium 是戊二酸的 α-羟基酸形式。α-Hydroxyglutaric acid disodium 是多种 α-酮戊二酸依赖性双加氧酶 (包括 histone demethylases 和 5-甲基胞嘧啶羟化酶 (5-methlycytosine (5mC) hydroxylases) 的 TET 家族) 的竞争性抑制剂。 | |||
| M49531 | Glycyl H-1152 hydrochloride | Glycyl H-1152 hydrochloride | ROCK |
| Glycyl H-1152 hydrochloride 是 Rho-kinase 抑制剂 H-1152 dihydrochloride 的糖基衍生物。 | |||
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