M2225
|
Thalidomide |
Thalidomide（沙利度胺）是一种 cereblon (cullin-4 E3 泛素连接酶复合物 CUL4-RBX1-DDB1 的一部分)抑制剂，Kd 值约为 250 nM。具有免疫调节，抗炎和抗肿瘤活性，可用于许多癌症的相关研究。 |
| M43862
|
4-Piperidinecarboxaldehyde, 1-[5-(2,6-dioxo-3-piperidinyl)-2-pyridinyl]- |
4-Piperidinecarboxaldehyde, 1-[5-(2,6-dioxo-3-piperidinyl)-2-pyridinyl]- |
| M43861
|
4-Piperidinecarboxylic acid, 1-[5-(2,6-dioxo-3-piperidinyl)-2-pyridinyl]-, 1,1-dimethylethyl ester |
4-Piperidinecarboxylic acid, 1-[5-(2,6-dioxo-3-piperidinyl)-2-pyridinyl]-, 1,1-dimethylethyl ester |
| M43860
|
1-[5-(2,6-Dioxo-3-piperidinyl)-3-fluoro-2-pyridinyl]-4-piperidineacetic acid |
1-[5-(2,6-Dioxo-3-piperidinyl)-3-fluoro-2-pyridinyl]-4-piperidineacetic acid |
| M43859
|
3-[6-[4-(Hydroxymethyl)-1-piperidinyl]-3-pyridinyl]-2,6-piperidinedione |
3-[6-[4-(Hydroxymethyl)-1-piperidinyl]-3-pyridinyl]-2,6-piperidinedione |
| M43858
|
3-[6-[4-(Methylamino)-1-piperidinyl]-3-pyridinyl]-2,6-piperidinedione |
3-[6-[4-(Methylamino)-1-piperidinyl]-3-pyridinyl]-2,6-piperidinedione |
| M43857
|
3-[6-(4-Amino-1-piperidinyl)-3-pyridinyl]-2,6-piperidinedione |
3-[6-(4-Amino-1-piperidinyl)-3-pyridinyl]-2,6-piperidinedione |
| M43856
|
3-[6-(1-Piperazinyl)-3-pyridinyl]-2,6-piperidinedione |
3-[6-(1-Piperazinyl)-3-pyridinyl]-2,6-piperidinedione |
| M43855
|
4-Piperidinecarboxaldehyde, 1-[6-(2,6-dioxo-3-piperidinyl)-3-pyridinyl]- |
4-Piperidinecarboxaldehyde, 1-[6-(2,6-dioxo-3-piperidinyl)-3-pyridinyl]- |
| M43854
|
3-(3-fluoro-4-(piperidin-4-yl)phenyl)piperidine-2,6-dione |
3-(3-fluoro-4-(piperidin-4-yl)phenyl)piperidine-2,6-dione |
| M43853
|
1-(4-(piperidin-4-yl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione |
1-(4-(piperidin-4-yl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione |
| M43852
|
3-(4-(piperidin-4-yl)phenyl)piperidine-2,6-dione |
3-(4-(piperidin-4-yl)phenyl)piperidine-2,6-dione |
| M43851
|
1-[5-(2,6-Dioxo-3-piperidinyl)-2-pyridinyl]-4-piperidineacetic acid |
1-[5-(2,6-Dioxo-3-piperidinyl)-2-pyridinyl]-4-piperidineacetic acid |
| M43850
|
2-[5-(2,6-Dioxo-3-piperidinyl)-2-pyridinyl]-2-azaspiro[3.3]heptane-6-acetic acid |
2-[5-(2,6-Dioxo-3-piperidinyl)-2-pyridinyl]-2-azaspiro[3.3]heptane-6-acetic acid |
| M43848
|
2,6-Piperidinedione, 3-[6-(4-piperidinyl)-3-pyridinyl]- |
2,6-Piperidinedione, 3-[6-(4-piperidinyl)-3-pyridinyl]- |
| M43847
|
1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidine-4-carbaldehyde |
1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidine-4-carbaldehyde |
| M43846
|
3-(4-(4-(hydroxymethyl)piperidin-1-yl)phenyl)piperidine-2,6-dione |
3-(4-(4-(hydroxymethyl)piperidin-1-yl)phenyl)piperidine-2,6-dione |
| M43845
|
3-[4-[3,3-Difluoro-4-(methylamino)-1-piperidinyl]phenyl]-2,6-piperidinedione |
3-[4-[3,3-Difluoro-4-(methylamino)-1-piperidinyl]phenyl]-2,6-piperidinedione |
| M43424
|
CRBN ligand-9 |
CRBN ligand-9 是一种 CRBN 配体 (Ki: 8.9 μM)。 |
| M43423
|
CC-3060 |
CC-3060 是促进 ZBTB16 降解的 Cereblon 调节剂。 |
| M43422
|
DCAF1 binder 1 |
DCAF1 binder 1 对 CRL4 DCAF1 E3 连接酶复合物具有选择性。 |
