M66251
|
Recombinant Human FTO Protein (HEK293, C-His) |
FTO 蛋白是一种 RNA 去甲基酶，通过靶向 mRNA 中的 N(6)-甲基腺苷来调节脂肪量、脂肪生成和能量稳态。它还使 U6 snRNA 中的 m6A 和 5'-cap 中的 m6A(m) 去甲基化，影响 mRNA 稳定性。 |
| M66215
|
Recombinant Human DHFR Protein (E. coli, N-His) |
DHFR蛋白是叶酸代谢中的关键酶，对多种代谢途径至关重要。它催化的一系列反应对于线粒体胸苷酸的从头合成、甘氨酸和嘌呤的从头合成以及DNA前体的合成都不可或缺。 |
| M66199
|
Recombinant Human ERBB3/HER3 (HEK293, C-Fc) |
ERBB3/HER3 belongs to the protein kinase superfamily,tyr protein kinase family and EGF receptor subfamily.It contains 1 protein kinase domain and it is expressed in Epithelial tissues and brain. |
| M66165
|
Recombinant Mouse MPO/Myeloperoxidase (HEK293, C-10His) |
Myeloperoxidase (MPO) is a heme-containing enzyme belonging to the XPO subfamily of peroxidases. MPO activity results in protein nitrosylation and the formation of 3-chlorotyrosine and dityrosine crosslinks. MPO is also associated with a variety of other diseases, and inhibits vasodilation in inflammation by depleting the levels of NO. |
| M66164
|
Recombinant Human MPO/Myeloperoxidase (HEK293, C-10His) |
Myeloperoxidase (MPO) is a heme-containing enzyme belonging to the XPO subfamily of peroxidases. MPO activity results in protein nitrosylation and the formation of 3-chlorotyrosine and dityrosine crosslinks. MPO is also associated with a variety of other diseases, and inhibits vasodilation in inflammation by depleting the levels of NO. |
| M66010
|
Recombinant Mouse ERBB3/HER3 (HEK293, C-6His) |
ERBB3/HER3 is an enzyme belongs to the protein kinase superfamily, tyr protein kinase family and EGF receptor subfamily. |
| M66009
|
Recombinant Human ERBB3/HER3 (HEK293, C-6His) |
ERBB3/HER3 is an enzyme belongs to the protein kinase superfamily, tyr protein kinase family and EGF receptor subfamily. |
| M59331
|
Recombinant Human MAPK3 Protein (E. coli, N-His) |
MAPK3 是MAP激酶途径中重要的丝氨酸/苏氨酸激酶，与MAPK1/ERK2配合激活MAPK/ERK级联。在 KIT 和 KITLG/SCF 的刺激下，该通路在细胞生长、粘附、存活和分化中发挥着关键作用。此外，MAPK/ERK 级联还涉及内体动力学、溶酶体加工、通过核周回收室 (PNRC) 的内体循环以及有丝分裂期间高尔基体的碎片。 |
| M59330
|
Recombinant Human MAPK14 Protein (E. coli, N-His) |
MAPK14 是 MAP 激酶途径中重要的丝氨酸/苏氨酸激酶。它可以对细胞因子或应激等刺激做出反应，并直接激活转录因子。此外，MAPK14 调节蛋白质翻译，影响细胞骨架重塑，并参与各种细胞过程，例如内体动力学、蛋白质周转和跨膜蛋白的胞外域脱落。 |
| M59329
|
Recombinant Human MAPK8 Protein (E. coli, N-His) |
MAPK8 是一种多功能丝氨酸/苏氨酸蛋白激酶，复杂地调节多种细胞过程，包括细胞增殖、凋亡和分化。MAPK8 是由 MAP2K4/MKK4 和 MAP2K7/MKK7 激活，磷酸化 AP-1 成分，并影响转录活性。 |
| M59216
|
Recombinant Mouse LDHA Protein (HEK293, C-6His) |
Lactate dehydrogenase A (LDHA) 乳酸脱氢酶 A 是 LDH/MDH 超家族和 LDH 家族的成员。LDHA 催化丙酮酸和 L-乳酸的相互转化，同时伴随 NADH 和 NAD+ 的相互转化。LDHA 存在于大多数体细胞组织中，但主要存在于肌肉组织和肿瘤中。LDHA 是调节有氧糖酵解的关键酶，属于乳酸脱氢酶家族，在许多人类癌症中过度表达。LDHA在恶性肿瘤的发展、侵袭和转移中起着重要作用。 |
| M59166
|
Recombinant Human LDH-B (E. coli, N-6His) |
L-Lactate Dehydrogenase B Chain (LDH-B) is a member of the lactate dehydrogenase family. LDH-B is an oxidoreductase that catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. It converts pyruvate to lactate when oxygen is absent or in short supply and it performs the reverse reaction during the Cori cycle in the liver. |
| M59026
|
Recombinant Human TIMP-1 (HEK293, C-6His) |
Tissue Inhibitor of Metalloproteinases 1 (TIMP-1) is a member of TIMP family. The homologous proteins of TIMPs regulate the activity of matrix metalloproteinases (MMPs), including inhibition of active MMPs, proMMP activation, cell growth promotion, matrix binding, inhibition of angiogenesis and the induction of apoptosis. |
| M58979
|
Recombinant Human DPP-4/CD26 Protein (HEK293, N-hFc) |
Dipeptidyl peptidase-4 (DPP4) is a serine exopeptidase belonging to the S9B protein family. The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV). As both a regulatory enzyme and a signalling factor, DPP4 has been evaluated and described in many studies. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). |
| M58978
|
Recombinant Human PKM2 (E. coli, N-6His) |
Pyruvate kinase isoform M2 (PKM2) is a member of the pyruvate kinase (PK) family. PKM2 promotes cell proliferation and suppresses cell apoptosis in various tumors. PKM2 is expressed in some differentiated tissues, such as lung, fat tissue, retina, and pancreatic islets. |
| M58611
|
Recombinant Human SOD1 Protein (E. coli, N-6His) |
SOD1 binds copper and zinc ions and is one of three isozymes responsible for destroying free superoxide radicals in the body. SOD1 neutralizes supercharged oxygen molecules, which can damage cells if their levels are not controlled. The enzyme protects the cell against dangerous levels of superoxide. |
| M58610
|
Recombinant Human SOD2 (HEK293, C-6His) |
SOD2 is a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. SOD2 transforms toxic superoxide, a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. |
| M55681
|
Recombinant Human MMP13 Protein (E. coli, N-His) |
MMP-13 蛋白在细胞外基质蛋白，尤其是纤维状胶原、纤连蛋白、TNC 和 ACAN 的降解中发挥作用。它可裂解三螺旋胶原蛋白，优先裂解 II 型胶原蛋白，还可以靶向其他胶原蛋白类型。 |
| M55549
|
Recombinant Mouse DPP-4/CD26 Protein (HEK293, N-hFc) |
Dipeptidyl peptidase-4 (DPP4, CD26) is a serine exopeptidase belonging to the S9B protein family. The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV). |
| M55024
|
Recombinant Human DPP4/CD26 (HEK293, C-6His) |
DPP4/CD26 is a signal-anchor for type II membrane protein that belongs to the peptidase S9B family. DPP4/CD26 acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. It’s binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. |
