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Recombinant Human MMP-1 (Mammalian, C-6His) 重组人MMP-1 蛋白(Mammalian, C-6His)

目录号 M21685 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


Recombinant Human MMP-1可降解多种底物,包括 I、II、III、VII、VIII 和 X 型胶原蛋白以及酪蛋白、明胶、α1 抗胰蛋白酶、髓磷脂碱性蛋白、L-选择蛋白、pro-TNF、IL1、IGFBP3 、IGFBP5、pro-MMP2 和 pro-MMP9。Recombinant Human Matrix Metalloproteinase-1 由哺乳动物表达系统产生,编码 Phe20-Asn469 的靶基因在 C 末端用 6His 标签表达。酶原需要被 APMA 激活以获得激活形式。

Recombinant Human MMP-1 (Mammalian, C-6His)结构式

别名:Matrix Metalloproteinase-1

规格 价格 库存状态
10ug ¥ 2430 中国库存现货
50ug ¥ 6480 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
生物活性

基质金属蛋白酶 1 (MMP-1) 由成纤维细胞、角质形成细胞、内皮细胞、单核细胞和巨噬细胞表达。MMP1 包含几个不同的结构域:激活后被切割的前结构域、包含锌结合位点的催化结构域、短铰链区和羧基末端(血红素结合蛋白样)结构域。

MMP-1 可降解多种底物,包括 I、II、III、VII、VIII 和 X 型胶原蛋白以及酪蛋白、明胶、α1 抗胰蛋白酶、髓磷脂碱性蛋白、L-选择蛋白、pro-TNF、IL1、IGFBP3 、IGFBP5、pro-MMP2 和 pro-MMP9。MMP1 的一个重要作用是在细胞外基质重塑中降解纤维状胶原,其特征是间质胶原三股螺旋裂解成 3/4、1/4 片段。MMP1 也可能参与酶级联反应。


蛋白编号:P03956

表观分子量:56 KDa

剂型描述:以 20mM MES、150mM NaCl、2mM CaCl2、1mM DTT、0.05%Brij35、10% 甘油的 0.2 μm 过滤溶液提供,pH 5.0。

化学性质
溶解性(25°C) Water
PBS
储存条件 Store at ≤-70°C, stable for 6 months after receipt
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Yizhen Wu, et al. Int J Biochem Cell Biol. MMP-1 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via the JNK and ERK pathway

[2] Zichen Li, et al. Cancer Sci. Activation of MMP-9 by membrane type-1 MMP/MMP-2 axis stimulates tumor metastasis

[3] Negar Asdaghi, et al. Mol Cell Biochem. Extracellular 14-3-3 from human lung epithelial cells enhances MMP-1 expression

[4] W Brian Saunders, et al. J Cell Sci. MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices

[5] Xiaoling Jiang, et al. J Orthop Res. Inhibition of MMP-1 expression by antisense RNA decreases invasiveness of human chondrosarcoma

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