Recombinant Human MMP-1可降解多种底物,包括 I、II、III、VII、VIII 和 X 型胶原蛋白以及酪蛋白、明胶、α1 抗胰蛋白酶、髓磷脂碱性蛋白、L-选择蛋白、pro-TNF、IL1、IGFBP3 、IGFBP5、pro-MMP2 和 pro-MMP9。Recombinant Human Matrix Metalloproteinase-1 由哺乳动物表达系统产生,编码 Phe20-Asn469 的靶基因在 C 末端用 6His 标签表达。酶原需要被 APMA 激活以获得激活形式。
别名:Matrix Metalloproteinase-1
基质金属蛋白酶 1 (MMP-1) 由成纤维细胞、角质形成细胞、内皮细胞、单核细胞和巨噬细胞表达。MMP1 包含几个不同的结构域:激活后被切割的前结构域、包含锌结合位点的催化结构域、短铰链区和羧基末端(血红素结合蛋白样)结构域。
MMP-1 可降解多种底物,包括 I、II、III、VII、VIII 和 X 型胶原蛋白以及酪蛋白、明胶、α1 抗胰蛋白酶、髓磷脂碱性蛋白、L-选择蛋白、pro-TNF、IL1、IGFBP3 、IGFBP5、pro-MMP2 和 pro-MMP9。MMP1 的一个重要作用是在细胞外基质重塑中降解纤维状胶原,其特征是间质胶原三股螺旋裂解成 3/4、1/4 片段。MMP1 也可能参与酶级联反应。
蛋白编号:P03956
表观分子量:56 KDa
剂型描述:以 20mM MES、150mM NaCl、2mM CaCl2、1mM DTT、0.05%Brij35、10% 甘油的 0.2 μm 过滤溶液提供,pH 5.0。
溶解性(25°C) | Water PBS |
储存条件 | Store at ≤-70°C, stable for 6 months after receipt |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
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