找到约 17 条 “Ten01” 相关结果 （用时 0.118 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
| M11858 | ChemBridge-5226501 | ChemBridge化合物-5226501 | Screening Compounds and Building Blocks |
| 4,4'-(4,4'-biphenyldiyldiimino)bis(4-oxo-2-butenoic acid) (5226501) | |||
| ChemBridge特有类药化合物/先导化合物-5226501，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M12734 | ChemBridge-6636019 | ChemBridge化合物-6636019 | Screening Compounds and Building Blocks |
| 4-{[3-(benzoylamino)phenyl]amino}-4-oxo-2-butenoic acid (6636019) | |||
| ChemBridge特有类药化合物/先导化合物-6636019，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M28217 | (S)-JQ-35 | (S)-JQ-35 | Epigenetic Reader Domain |
| TEN-010 | |||
| (S)-JQ-35 (TEN-010) 是 BET 家族的抑制剂，有着潜在的抗肿瘤活性。 | |||
| M49623 | Ten01 | Ten01 | JAK |
| Ten01 对 JAK1 激酶具有 5.0 nM 抑制活性。 | |||
M2008
|
ICG-001 | ICG-001 | Wnt/beta-catenin |
| PRI-724 isomer | |||
| ICG-001是一种β-catenin/CBP互作抑制剂，主要通过结合 CREB 蛋白起作用，IC50 为3 μM，ICG-001不会与相关的转录共激活因子p300结合。在体实验中，ICG-001能够选择性地诱导肿瘤细胞发生凋亡，而对正常细胞的影响较小。 | |||
M3973
|
Tazarotene | 他扎罗汀 | RAR/RXR |
| Tazorac; Zorac; AGN 190168 | |||
| Tazarotene (AGN 190168) 是一种视黄酸衍生物，同时也是选择性的视黄酸受体 (RAR) 激动剂，并能通过触发半胱天冬酶依赖性细胞凋亡在人类基底细胞癌 (BCC) 中表现出抗增殖作用。可用于多种皮肤病（如银屑病）的相关研究。 | |||
| M9478
|
SKL2001 | SKL2001 | Wnt/beta-catenin |
| Wnt Agonist II | |||
| SKL2001 是一种Wnt/β-catenin信号通路的激动剂，通过破坏Axin/β-catenin的相互作用，稳定细胞内的β-catenin蛋白水平，从而激活Wnt/β-catenin信号通路。SKL2001可调节细胞分化与增殖，还具有抗肿瘤活性。 | |||
| M14939
|
β-catenin-IN-2 | β-catenin-IN-2 | Wnt/beta-catenin |
| β-catenin-IN-2 是一种有效的 β-catenin 抑制剂，化合物 H1B1，源于专利 US20150374662A1。β-catenin-IN-2 可用于结直肠癌的研究。 | |||
| M19986
|
Recombinant Human CXCL6 (HEK293, C-6His) | 重组人CXCL6 蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
| C-X-C Motif Chemokine 6; Chemokine Alpha 3 | |||
| Chemokine (C-X-C-Motif) Ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family. CXCL6 can promote the release of MMP-9 from granulocytes indicating its potential role as an inflammatory mediator. It functionally uses both of the IL-8/CXCL8 receptors to chemoattract neutrophils but that is structurally most related to epithelial cell-derived neutrophil attractant-78 (ENA-78)/CXCL5. Accession: P80162. | |||
| M20477 | 7-Hydroxyflavone | 7-Hydroxyflavone | Cytochrome P450 (e.g. CYP17) |
| 7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2. It also has excellent antioxidant properties and great potential to be applied as medicines. | |||
| M20669
|
CZC-54252 | CZC-54252 | LRRK2 |
| CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for human wild type LRRK2 and G2019S LRRK2, respectively. | |||
| M20699 | R-10015 | R-10015 | Others |
| R-10015 is a potent, selective inhibitor of LIM domain kinase (LIMK) with IC50 of 38 nM for human LIMK1. R-10015 binds to the ATP-binding pocket and acts as a broad-spectrum antiviral compound for HIV infection. | |||
| M20707
|
RK 24466 | RK 24466 | Src-bcr-Abl |
| KIN 001-51, Lck inhibitor C 8863, C8863 | |||
| RK-24466 (KIN 001-51) is a potent and selective inhibitor of Lck that inhibits two constructs of the human lck kinase, lck (64-509) and lckcd with IC50 of < 0.001 μM and 0.002 μM, respectively. | |||
| M25441
|
Recombinant Human Endothelin B Receptor Protein (HEK293, His Tag) | 重组人EDNRB蛋白 (HEK293, His Tag) | Cytokines and Growth Factors |
| human EDNRB | |||
| EDNRB is a new candidate tumor suppressor gene which is often down-regulated or even silenced by promoter hypermethylation in various human cancers. The recombinant human EDNRB consists 86 amino acids and predicts a molecular mass of 9.5 kDa. A DNA sequence encoding the human EDNRB (NP_000106.1) (Met1-Lys101) was expressed with a polyhistidine tag at the C-terminus. | |||
| M28379 | UU-T01 | UU-T01 | Wnt/beta-catenin |
| UU-T01 是 β-Catenin/T-cell factor 4 蛋白互作 (β-catenin/Tcf PPI) 的选择性抑制剂，Ki 值为 3.14 µM。UU-T01 与 β-catenin 直接结合，KD 值为 0.531 µM。 | |||
| M28645 | Azilsartan mepixetil | Azilsartan mepixetil | Angiotensin Receptor |
| Azilsartan mepixetil 是血管紧张素 II 受体 (angiotensin II receptor) 的拮抗剂。Azilsartan mepixetil 具有更强更持久的降压作用，更明显和更持久的降心率作用，安全性高。Azilsartan mepixetil 对心脏和肾脏功能具有理想的保护作用。Azilsartan mepixetil 具有研究高血压、慢性心力衰竭和糖尿病肾病的潜力 (信息摘自专利 CN107400122A)。 | |||
| M57233 | CGK012 | CGK012 | Wnt/beta-catenin |
| CKG012 是 Wnt/βcatenin 信号通路抑制剂。CGK012 抑制 HMGB1 的释放和 β-catenin 的转录，对改善盲肠结扎和穿刺引发的脓毒症和多发性骨髓瘤癌症具有活性。 | |||
