找到约 15 条 “STAT6-IN-1” 相关结果 (用时 0.129 秒)
目录号 | 产品名称 | 中文名称 | 靶点 |
---|---|---|---|
M49689 | STAT6-IN-1 | STAT6-IN-1 | STAT |
STAT6-IN-1 是一种 STAT6 抑制剂,对 STAT6 的 SH2 结构域具有较高的亲和力 (IC50=0.028 µM)。 | |||
M2123 | Rocilinostat | Rocilinostat | HDAC |
ACY-1215; Ricolinostat | |||
Rocilinostat (ACY-1215)是一种选择性HDAC6抑制剂, IC50为5 nM,作用于HDAC6比作用于HDAC1/2/3(I型HDACs)选择性高10倍以上,对HDAC8具有微弱的作用活性,对HDAC4/5/7/9/11, Sirtuin1和Sirtuin2具有最低限度的作用活性。 | |||
M2147 | GM6001 | GM6001 | MMP |
Galardin | |||
Ilomastat (GM6001, Galardin)是一种广谱matrix metalloprotease (MMP)(基质金属蛋白酶)抑制剂,作用于MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14,和MMP-26,Ki分别为0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM,和0.36 nM。 | |||
M2376 | Aloxistatin | 阿洛司他丁 | Cathepsin |
E64d | |||
Aloxistatin(E64d)是一种不可逆的膜透过性组织蛋白酶B(Cathepsin B)的抑制剂,可用于阿尔兹海默症的研究。Aloxistatin (E64d) 抑制蛋白酶抗性朊病毒蛋白 (PrP-res) 在 ScNB 细胞中的积累,IC50 为 0.5±0.11 μM。 | |||
M2677 | Tazemetostat (EPZ-6438) | 他泽司他;塔泽托斯 | EZH2 |
Tazemetostat; E7438 | |||
Tazemetostat (EPZ-6438)是一款首创的(first-in-class),选择性EZH2抑制剂,Ki为2.5 nM,比作用于EZH1选择性高35倍,比作用于14种其他HMT选择性高4,500多倍。 | |||
M3970 | Scutellarin | 灯盏花乙素;野黄芩苷 | STAT |
Scutellarin (野黄芩苷)是一种黄酮类苷类化合物,在 HCC 细胞中,能够下调 STAT3/Girdin/Akt 信号通路,具有抗 HIV-1IIIB,HIV-1(74V) 和 HIV-1KM018 的活性,EC50 分别为 26 μM,253 μM 和 136 μM。Scutellarin 部分通过调节 PKA 信号通路抑制巨噬细胞中 caspase-11 的激活和细胞焦亡。 | |||
M20389 | Quisinostat (JNJ-26481585) 2HCl | Quisinostat (JNJ-26481585) 2HCl | HDAC |
Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11 greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2. | |||
M20718 | Tubastatin A TFA | Tubastatin A TFA | HDAC |
Tubastatin A trifluoroacetate salt | |||
Tubastatin A TFA (Tubastatin A trifluoroacetate salt) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Tubastatin A promotes autophagy and increases apoptosis. | |||
M20724 | RCM-1 | RCM-1 | IL Receptor/Related |
Robert Costa Memorial drug-1 | |||
RCM-1 is a nontoxic inhibitor of Forkhead box M1 (FOXM1) that suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. RCM-1 decreases carcinogenesis and nuclear β-catenin. | |||
M25396 | Recombinant Human Oncostatin M (OSM) (E. coli, 209aa) | 重组人Oncostatin M (E. coli, 209aa) | Recombinant Proteins |
OSM | |||
Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, which also includes IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. ED50 < 10.0 ng/ml, measured by a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 1.0 × 105 units/mg. | |||
M25397 | Recombinant Human Oncostatin M (OSM) (E. coli, 227aa) | 重组人Oncostatin M (E. coli, 227aa) | Recombinant Proteins |
OSM | |||
Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, including IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. ED50 < 10.0 ng/ml, measured by a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 1.0 × 105 units/mg. | |||
M27774 | Crebinostat | Crebinostat | HDAC |
Crebinostat 是一种有效的组蛋白去乙酰化酶 (HDAC) 抑制剂,对 HDAC1、HDAC2、HDAC3 和 HDAC6 的 IC50 分别为 0.7 nM、1.0 nM、2.0 nM 和 9.3 nM。Crebinostat 可诱导组蛋白 H3 和组蛋白 H4 乙酰化,并增强 cAMP 反应元件结合蛋白 (CREB) 靶基因 Egr1 的表达。 | |||
M30035 | Spliceostatin A | Spliceostatin A | Others |
Spliceostatin A,是 FR901464 的甲基化衍生物,是一种有效的抗肿瘤活性分子。Spliceostatin A 通过结合 SF3B1 抑制剪接并促进前体 mRNA 的积累。SF3B1 是剪接体中 U2 小核核糖核蛋白的一个亚复合体。Spliceostatin A 诱导慢性淋巴细胞白血病 (CLL) 细胞凋亡 (Apoptosis)。 | |||
M41300 | CDK8-IN-13 | CDK8-IN-13 | Apoptosis |
CDK8-IN-13 is a potent, selective and orally active CDK8 inhibitor with an IC50 value of 51.9 nM. CDK8-IN-13 induces Apoptosis. CDK8-IN-13 decreases the expression of p-STAT1 S727 and p-STAT5 S726. CDK8-IN-13 shows antitumor activity.。 | |||
M42111 | HJC0416 | HJC0416 | STAT |
HJC0416 是一种有效的口服活性 STAT3 抑制剂 HJC0416 显示出抗增殖活性并诱导细胞凋亡 (apoptosis). HJC0416 降低 p-STAT3 (Tyr-705)、Cyclin D1 的表达并增加cleaved caspase-3 蛋白的表达。 |
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