找到约 15 条 “S-Gem” 相关结果 （用时 0.283 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M25059
|
Sugemalimab | 舒格利单抗 | PD-1/PD-L1 |
| Sugemalimab 是一种完整的人全长抗程序性死亡配体 1 (PD-L1) 免疫球蛋白 G4 (IgG4) 单克隆抗体 (mAb)。Sugemalimab 显示出抗癌活性，可用于非小细胞肺癌的研究。 | |||
| M41547 | S-Gem | S-Gem | Nucleoside Antimetabolite/Analog |
| S-Gem 是 Gemcitabine 的 TrxR 依赖性前体化合物，由 TrxR 选择性激活。 | |||
| M4976
|
Ivabradine | 伊伐布雷定 | HCN Channel |
| Ivabradine is a novel medicine indicated for the symptomatic management of stable angina pectoralis. | |||
M5680
|
Gemcitabine | 吉西他滨 | DNA/RNA Synthesis |
| NSC 613327; LY188011 | |||
| Gemcitabine (LY-188011，NSC 613327，吉西他滨) 是DNA合成抑制剂，对PANC1，MIAPaCa2，BxPC3和Capan2细胞的IC50分别为50 nM，40 nM，18 nM和12 nM。Gemcitabine 抑制 DNA 合成 (DNA synthesis) 和修复，导致细胞自噬 (autophagy) 和凋亡 (apoptosis)。可用于胰腺癌和非小细胞肺癌（NSCLC）的相关研究。 | |||
| M8507 | Tonabersat | Tonabersat | Others |
| SB-220453 | |||
| Tonabersat is a potent inhibitor of neuronal-glial gap junctions in trigeminal ganglion that inhibits cortical spreading depression (CSD) and neurogenic inflammation in animal models of migraine. | |||
| M11418
|
SAR-020106 | SAR-020106 | Checkpoint |
| SAR-020106 是一种 ATP 竞争性的、选择性好的 CHK1 抑制剂，IC50 为 13.3 nM。SAR-020106 对 CHK2 具有良好的选择性。SAR-020106 在几种结肠肿瘤细胞系中以 p53 依赖性方式将 Gemcitabine 和 SN38 的细胞杀伤力提高了 3.0 到 29 倍。SAR-020106 可通过选择抗癌药物增强抗肿瘤活性。 | |||
| M20445
|
Indometacin Sodium | Indometacin Sodium | Others |
| Indometacin is a non-steroidal anti-inflammatory drug (NSAID) used most commonly for the treatment of inflammation and pain resulting from rheumatic disease (arthritis), and less commonly in postoperative pain management. When taken for chronic pain conditions, indometacin has been associated with a high incidence of adverse events. The benefits and harms of orally-administered indometacin for postoperative pain are not clear. | |||
| M20485 | Phenylglyoxal hydrate | Phenylglyoxal hydrate | Dehydrogenase |
| 1-Phenylethanedione hydrate | |||
| Phenylglyoxal is a potent inhibitor of mitochondrial aldehyde dehydrogenase. It reacts with arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties. | |||
| M20988 | Promethazine | Promethazine | Histamine Receptor |
| Promethazine is a potent histamine H1 receptor antagonist. Promethazine is a medication used in the management and treatment of allergic conditions, nausea and vomiting, motion sickness, and sedation. Promethazine exhibits antiparasitic properties. | |||
| M21014 | edetate calcium disodium | edetate calcium disodium | Others |
| EDTA calcium disodium | |||
| Edetate calcium disodium is a chelating agent that is primarily used for the management of severe lead poisoning. | |||
| M27924 | GNE-900 | GNE-900 | Checkpoint |
| GNE-900 是一种 ATP 竞争性、选择性和口服活性 ChK1 抑制剂，对ChKl, ChK2 的IC50 值分别为为 0.0011，1.5 µM。GNE-900 废除 G2-M 检查点，增强 DNA 损伤，并诱导胞凋亡 (Apoptosis)。gemcitabine 和 GNE-900 给药显示抗肿瘤活性< /sup>。 | |||
| M41200 | Viral polymerase-IN-1 hydrochloride | Viral polymerase-IN-1 hydrochloride | Anti-infection |
| Viral polymerase-IN-1 hydrochloride 是一种 Gemcitabine 衍生物，有效抑制甲型和乙型流感病毒 (influenza) 感染，IC90 值为 11.4-15.9 μM。 | |||
| M43167 | C-Gem | C-Gem | Others |
| C-Gem 是 S-Gem 的对照。 | |||
| M51738 | Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) | Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) | Others |
| Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) (c(RGDfE)) 是一种环状 RGD 肽，可作为共轭多功能纳米药物递送系统，将 Gemcitabine 靶向至胰腺癌细胞。 | |||
| M55984 | SOP1812 | SOP1812 | Others |
| SOP1812 (QN-302) 是一种 naphthalene diimide (ND) 衍生物，具有抗肿瘤活性。SOP1812 能够与quadruplex arrangements (G4s) 结合，并下调多个癌症基因通路。 | |||
