找到约 24 条 “INH14” 相关结果 （用时 0.11 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M5347
|
Y15 | Y15 | FAK |
| FAK inhibitor Y15; FAK Inhibitor 14 | |||
| Y15是新型FAK激酶磷酸化抑制剂，能特异性抑制Y397-FAK和total-FAK磷酸化。 | |||
| M20672 | INH14 | INH14 | NF-κB |
| INH14 is an inhibitor of TLR2-mediated NF-kB activation with IC50 values of 8.975 μM and 3.598 μM for IKKα and IKKβ, respectively. | |||
| M41315 | Mcl-1 inhibitor 14 | Mcl-1 inhibitor 14 | Bcl-2 |
| Mcl-1 inhibitor 14 是 髓系细胞白血病 -1 (MCL-1) 的抑制剂，Ki 为 0.018 nM，可用于抗癌研究。 | |||
| M41613 | Topoisomerase II inhibitor 14 | Topoisomerase II inhibitor 14 | Topoisomerase |
| Topoisomerase II inhibitor 14 是拓扑异构酶 II 的有效抑制剂，具有抗癌活性。 | |||
| M42231 | P-gp inhibitor 14 | P-gp inhibitor 14 | P-glycoprotein |
| P-gp inhibitor 14 是一种高亲和力 P-gp 抑制剂。 | |||
| M5298
|
NSC-144303 | NSC-144303 | Apoptosis |
| Ubiquitin Isopeptidase Inhibitor I, G5 | |||
| Ubiquitin Isopeptidase Inhibitor I, G5（NSC-144303）是一种广谱的可透过细胞的去泛素化酶（DUB）抑制剂，可影响由poly(I:C)诱导的I型 IFNs和NF-κB。 | |||
| M8439 | SMI481 | SMI481 | Others |
| SMI481 is a selective small-molecule inhibitor (SMI) of the yeast phosphatidylinositol transfer protein (PITP) Sec14, a key regulator of phosphoinositide signaling, regulating membrane trafficking through the trans-Golgi network and endosomal systems. | |||
| M8496 | NSC687852 | NSC687852 | Others |
| NSC687852 is a cell-permeable, potent, reversible and selective inhibitor of 19S regulatory-particle-assoc |
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| M8835 | UA62784 | UA62784 | Others |
| Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor. | |||
| M10183
|
Difopein TFA | Difopein TFA | Peptides |
| Difopein TFA is a specific and competitive inhibitor of 14-3-3 protein, blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. | |||
| M20497 | 2’-deoxyuridine | 2’-deoxyuridine | Others |
| 2'-Deoxyuridine is an inhibitor of HSV-1 pyrimidine deoxythymidine kinase using 2-[14C]deoxythymidine as substrate. | |||
| M20632 | Selective PI3Kδ Inhibitor 1 (compound 7n) | Selective PI3Kδ Inhibitor 1 (compound 7n) | PI3K |
| Selective PI3Kδ Inhibitor 1 (compound 7n) is an inhibitor of PI3Kδ with an IC50 of 0.9 nM and >1000-fold selectivity against other class I PI3K isoforms [PI3K α/γ/β=3670/1460/21300 nM]. | |||
| M20730
|
KGA-2727 | KGA-2727 | SGLT |
| KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models. | |||
| M20733 | SP-96 | SP-96 | Aurora Kinase |
| SP-146 is a potent, selective and non-ATP-competitive inhibitor of Aurora B with IC50 of 0.316 nM. SP-146 can be used for the research of triple negative breast cancer (TNBC). | |||
| M21035 | LCH-7749944 | LCH-7749944 | PAK |
| GNF-PF-2356 | |||
| LCH-7749944 (GNF-PF-2356) is a novel and potent p21-activated kinase 4 (PAK4) inhibitor with an IC50 of 14.93 μM and has less potently inhibitory effect against PAK1, PAK5 and PAK6. LCH-7749944 causes successful inhibition of EGFR activity due to its inhibitory effect on PAK4. | |||
| M21042 | DCPIB | DCPIB | Potassium Channel |
| DCPIB is a specific and potent inhibitor of volume-regulated anion channels (VRAC). DCPIB potently inhibits several K2P channels with no voltage dependence, including TRESK, TASK1, and TASK3. DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM. | |||
| M27728 | Tubulin inhibitor 6 | Tubulin inhibitor 6 | Microtubule |
| Tubulin inhibitor 6 (Compound 14b) 是一种微管蛋白 (tubulin) 抑制剂，也是多种肿瘤细胞系的有效抑制剂。Tubulin inhibitor 6 抑制微管蛋白聚合，IC50 为 0.87 μM。Tubulin inhibitor 6 抑制 K562 细胞生长，IC50 为 840 nM。 | |||
| M29181 | PARP14 inhibitor H10 | PARP14 inhibitor H10 | PARP |
| PARP14 inhibitor H10 (化合物 H10) 是针对 PARP14 的选择性抑制剂 (IC50=490 nM)，是其他 PARP 的抑制剂 (约为 PARP1 的 24 倍)。PARP14 抑制剂 H10 诱导 caspase-3/7 介导的细胞凋亡 (apoptosis)。 | |||
| M41594 | CaMKP inhibitor sodium | CaMKP inhibitor sodium | ROCK |
| CaMKP inhibitor sodium是选择性的 ROCK1 抑制剂，IC50 值为14 nM。 | |||
| M53939 | 187-1, N-WASP inhibitor | 187-1, N-WASP inhibitor | Others |
| 187-1, N-WASP inhibitor 是一种14-aa 环肽，也是一种变构神经 Wiskott Aldrich 综合征蛋白 (N-WASP) 抑制剂。 | |||
| M56583 | UT-B-IN-1 | UT-B-IN-1 | Others |
| UT-B-IN-1 (UTBINH-14) 是一种可逆的，竞争性的以及选择性的尿素转运蛋白 B (UT-B) 抑制剂，对人和小鼠的 UT-B 的 IC50 分别为 10 和 25 nM。UT-B-IN-1 具有低毒性和高选择性相比于 UT-A 亚型。 | |||
| M56737 | PTP Inhibitor IV | PTP Inhibitor IV | Phosphatase |
| PTP Inhibitor IV 是一种蛋白酪氨酸磷酸酶 (PTP) 抑制剂，可竞争性抑制 DUSP14 磷酸酶活性，50 为 5.21 μM。 | |||
| M56779 | Proteasome inhibitor IX | Proteasome inhibitor IX | Proteasome |
| Proteasome inhibitor IX (PS-IX; AM114) 是一种 20S 蛋白酶体 (20S proteasome) 的胰凝乳蛋白酶样活性抑制剂，IC50 值约为 1 μM。Proteasome inhibitor IX 具有 HCT116 p53+/+ 细胞生长抑制活性，IC50 值为 1.49 μM。 | |||
| M58200 | 14-3-3η Protein inhibitor 1 | 14-3-3η Protein inhibitor 1 | Apoptosis |
| 14-3-3η Protein inhibitor 1 是一种 14-3-3η 蛋白抑制剂，KD 值为 35 µM。 | |||
