F-CRI1 - 搜索结果 | AbMole中文官网

找到约 12 条 “F-CRI1” 相关结果（用时 0.16 秒）

目录号	产品名称	中文名称	靶点
M20941	Raloxifene	雷洛昔芬	Estrogen Receptor
	Keoxifene, Pharoxifene, LY-139481, LY-156758, CCRIS-7129
	Raloxifene（雷洛昔芬）是第二代选择性雌激素受体（ER）调节剂（SERM），可用于乳腺癌和骨质疏松症的相关研究。
M42059	F-CRI1	F-CRI1	STING
	F-CRI1 是一种有效的 STING 激动剂，Kd 值为 40.62 nM。
M2294	Brefeldin A	布雷非德菌素A；蓝菌素A	ATPase
	BFA; Cyanein; Decumbin
	Brefeldin A是一种内酯抗生素，同时也是蛋白质转运的抑制剂，并能诱导癌细胞分化和凋亡，作用于HCT 116细胞，其IC50为0.2 μM。此外，Brefeldin A 还是一种 CRISPR/Cas9 激动剂，可抑制 HSV-1病毒，并具有抗癌活性。
M8641	LP117	LP117	Others
	LP117 is a pirinixic acid derivative that interferes with ATP-binding cassette (ABC) transporter ABCB1-mediated substrates transport, including vincristine, vinorelbine, paclitaxel, and actinomycin D, but not doxorubicin, rhodamine 123, or JC-1.
M8767	MIND4-17	MIND4-17	Others
	MIND4-17 is a potent NRF2 (nuclear factor erythroid 2-related factor 2) activator that covalently modifies a critical stress-sensor cysteine (C151) in the BTB domain of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEAP1).
M20775	SEC inhibitor KL-1	SEC inhibitor KL-1	Others
	KL-1
	SEC inhibitor KL-1 (KL-1) is a potent and selective inhibitor of super elongation complex (SEC) that disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with Ki of 3.48 μM.
M20783	Tenofovir alafenamide hemifumarate	Tenofovir alafenamide hemifumarate	Reverse Transcriptase
	TAF hemifumarate, GS-7340 hemifumarate
	Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
M21048	Methylprednisolone Acetate	Methylprednisolone Acetate	Others
	NSC-19987 acetate, Medrol acetate
	Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
M24696	Ascrinvacumab	Ascrinvacumab	ALK
	Anti-ACVRL1/ALK-1 Reference Antibody; PF-03446962
	Ascrinvacumab (PF-03446962) 是一种人 IgG2 单克隆抗体，靶向 ALK-1。Ascrinvacumab 显示出与人 ALK1 的结合效能，Kd 值为 7 nM。Ascrinvacumab 可用于肝细胞癌 (HCC) 的研究。
M40811	Recombinant Mouse CCL21 Protein (E. coli)	重组小鼠CCL21蛋白 (E. coli)	Recombinant Proteins
	C-C Motif Chemokine 21a
	C-C Motif Chemokine 21a (CCL21) is a small secreted cytokine that belongs to the intercrine beta (CC chemokine) family. Mouse CCL21 inhibits hemopoiesis and stimulates chemotaxis. It has chemotactic function in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils.
M40995	Recombinant Rat CXCL16 Protein (HEK293, C-His)	重组大鼠CXCL16蛋白 (HEK293, C-His)	Recombinant Proteins
	chemokine (C-X-C motif) ligand 16
	C-X-C motif chemokine 16 (CXCL16) is a single-pass type I membrane protein which belongs to the intercrine alpha (chemokine CxC) family. CXCL16 is a protein which shares pattern recognition receptor functions, relevant for adhesion and phagocytosis of bacterial products, with the properties of an adhesion molecule and inflammatory chemokine.
M55195	Recombinant Mouse Lumican (Mammalian, C-6His)	重组小鼠Lumican (Mammalian, C-6His)	Recombinant Proteins
	Keratan sulfate proteoglycan lumican; KSPGL
	Lumican binds to laminin. It has positive regulation of transcription from RNA polymerase II promoter and transforming growth factor beta1 production.

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