找到约 14 条 “F-CRI1” 相关结果 (用时 0.105 秒)
目录号 | 产品名称 | 中文名称 | 靶点 |
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M20941
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Raloxifene | 雷洛昔芬 | Estrogen Receptor |
Keoxifene, Pharoxifene, LY-139481, LY-156758, CCRIS-7129 | |||
Raloxifene(雷洛昔芬)是第二代选择性雌激素受体(ER)调节剂(SERM),可用于乳腺癌和骨质疏松症的相关研究。 | |||
M42059 | F-CRI1 | F-CRI1 | STING |
F-CRI1 是一种有效的 STING 激动剂,Kd 值为 40.62 nM。 | |||
M2294
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Brefeldin A | 布雷非德菌素A;蓝菌素A | ATPase |
BFA; Cyanein; Decumbin | |||
Brefeldin A是一种内酯抗生素,同时也是蛋白质转运的抑制剂,并能诱导癌细胞分化和凋亡,作用于HCT 116细胞,其IC50为0.2 μM。此外,Brefeldin A 还是一种 CRISPR/Cas9 激动剂,可抑制 HSV-1病毒,并具有抗癌活性。 | |||
M8641 | LP117 | LP117 | Others |
LP117 is a pirinixic acid derivative that interferes with ATP-binding cassette (ABC) transporter ABCB1-mediated substrates transport, including vincristine, vinorelbine, paclitaxel, and actinomycin D, but not doxorubicin, rhodamine 123, or JC-1. | |||
M8767 | MIND4-17 | MIND4-17 | Others |
MIND4-17 is a potent NRF2 (nuclear factor erythroid 2-related factor 2) activator that covalently modifies a critical stress-sensor cysteine (C151) in the BTB domain of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEAP1). | |||
M9302
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CBL0137 | CBL0137 | p53 |
Curaxin 137; CBL-C137 | |||
CBL0137是一种组蛋白伴侣蛋白FACT(Facilitates Chromatin Transcription)的抑制剂。CBL0137通过抑制FACT的功能,干扰染色质的动态平衡,从而影响DNA复制、转录和损伤修复过程。此外,它还具有激活p53通路、抑制NF-κB信号通路以及诱导免疫原性细胞死亡等多种活性。 | |||
M20775 | SEC inhibitor KL-1 | SEC inhibitor KL-1 | Others |
KL-1 | |||
SEC inhibitor KL-1 (KL-1) is a potent and selective inhibitor of super elongation complex (SEC) that disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with Ki of 3.48 μM. | |||
M20783 | Tenofovir alafenamide hemifumarate | Tenofovir alafenamide hemifumarate | Reverse Transcriptase |
TAF hemifumarate, GS-7340 hemifumarate | |||
Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection. | |||
M21048 | Methylprednisolone Acetate | Methylprednisolone Acetate | Others |
NSC-19987 acetate, Medrol acetate | |||
Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis. | |||
M24696 | Ascrinvacumab | Ascrinvacumab | ALK |
Anti-ACVRL1/ALK-1 Reference Antibody; PF-03446962 | |||
Ascrinvacumab (PF-03446962) 是一种人 IgG2 单克隆抗体,靶向 ALK-1。Ascrinvacumab 显示出与人 ALK1 的结合效能,Kd 值为 7 nM。Ascrinvacumab 可用于肝细胞癌 (HCC) 的研究。 | |||
M55397
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Recombinant Human HMGB1 Protein (E. coli) | 重组人HMGB1 蛋白 (E. coli) | Other Proteins |
High Mobility Group Protein B1 | |||
High mobility group protein B1 is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. As a nuclear protein, HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile, it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte, T cell, dendritic cell activities in inflammatory responses. | |||
M40811
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Recombinant Mouse CCL21 Protein (E. coli) | 重组小鼠CCL21蛋白 (E. coli) | Cytokines and Growth Factors |
C-C Motif Chemokine 21a | |||
C-C Motif Chemokine 21a (CCL21) is a small secreted cytokine that belongs to the intercrine beta (CC chemokine) family. Mouse CCL21 inhibits hemopoiesis and stimulates chemotaxis. It has chemotactic function in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. | |||
M40995
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Recombinant Rat CXCL16 Protein (HEK293, C-His) | 重组大鼠CXCL16蛋白 (HEK293, C-His) | Cytokines and Growth Factors |
chemokine (C-X-C motif) ligand 16 | |||
C-X-C motif chemokine 16 (CXCL16) is a single-pass type I membrane protein which belongs to the intercrine alpha (chemokine CxC) family. CXCL16 is a protein which shares pattern recognition receptor functions, relevant for adhesion and phagocytosis of bacterial products, with the properties of an adhesion molecule and inflammatory chemokine. | |||
M55195
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Recombinant Mouse Lumican (HEK293, C-6His) | 重组小鼠Lumican (HEK293, C-6His) | Cytokines and Growth Factors |
Keratan sulfate proteoglycan lumican; KSPGL | |||
Lumican binds to laminin. It has positive regulation of transcription from RNA polymerase II promoter and transforming growth factor beta1 production. |