找到约 50 条 “DIF-3” 相关结果 （用时 0.125 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M7742
|
DIF-3 | DIF-3 | GSK-3 |
| DIF3 | |||
| DIF-3（分化诱导因子3）是 DIF-1 的单氯化代谢物，由盘状芽孢杆菌产生，DIF-3是一种GSK-3β的激活剂和 Wnt/β-catenin 信号通路抑制剂。 DIF-3通过激活 GSK-3β 促进cyclin D1 和 c-Myc 的降解，从而降低 cyclin D1 和 c-Myc 的表达水平，导致细胞周期阻滞，可用于肿瘤抑制的研究。 | |||
| M11644 | ChemBridge-5118984 | ChemBridge化合物-5118984 | Screening Compounds and Building Blocks |
| 4-(3,4-difluorophenyl)-1,3-thiazol-2-amine (5118984) | |||
| ChemBridge特有类药化合物/先导化合物-5118984，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11824 | ChemBridge-5213291 | ChemBridge化合物-5213291 | Screening Compounds and Building Blocks |
| 4,4-difluoro-3,5-dihydroxy-1,7-diphenyl-2,5-heptadiene-1,7-dione (5213291) | |||
| ChemBridge特有类药化合物/先导化合物-5213291，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M12075 | ChemBridge-5416437 | ChemBridge化合物-5416437 | Screening Compounds and Building Blocks |
| 1-{4-[4-(2,5-difluorobenzyl)-1-piperazinyl]phenyl}ethanone (5416437) | |||
| ChemBridge特有类药化合物/先导化合物-5416437，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M12376 | ChemBridge-5807293 | ChemBridge化合物-5807293 | Screening Compounds and Building Blocks |
| 3-{[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]amino}phenol hydrochloride (5807293) | |||
| ChemBridge特有类药化合物/先导化合物-5807293，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M12635 | ChemBridge-6237876 | ChemBridge化合物-6237876 | Screening Compounds and Building Blocks |
| 2-({1-[3-(4-bromo-2,6-difluorophenoxy)-2-hydroxypropyl]-4-piperidinyl}methyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione hydrochloride (6237876) | |||
| ChemBridge特有类药化合物/先导化合物-6237876，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M12891 | ChemBridge-7260921 | ChemBridge化合物-7260921 | Screening Compounds and Building Blocks |
| N-[2-(2-chloro-4,5-difluorophenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide (7260921) | |||
| ChemBridge特有类药化合物/先导化合物-7260921，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M21255 | ChemBridge-9308560 | ChemBridge化合物-9308560 | Screening Compounds and Building Blocks |
| 4-(3,4-difluorophenyl)-1,3-dimethyl-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one | |||
| ChemBridge特有类药化合物/先导化合物-9308560，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M45479 | ChemBridge-5176958 | ChemBridge化合物-5176958 | Screening Compounds and Building Blocks |
| 2,5-difluoro-N,N,N',N'-tetramethyl-4,6-bis(trifluoromethyl)-1,3-benzenediamine (5176958) | |||
| ChemBridge特有类药化合物/先导化合物-5176958，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M45572 | ChemBridge-5416148 | ChemBridge化合物-5416148 | Screening Compounds and Building Blocks |
| 1-(2,5-difluorobenzyl)-3-piperidinecarboxamide (5416148) | |||
| ChemBridge特有类药化合物/先导化合物-5416148，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M45991 | ChemBridge-6799560 | ChemBridge化合物-6799560 | Screening Compounds and Building Blocks |
| 2-[(3,5-difluorophenyl)amino]-3-(1-piperidinyl)naphthoquinone (6799560) | |||
| ChemBridge特有类药化合物/先导化合物-6799560，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M46111 | ChemBridge-7290040 | ChemBridge化合物-7290040 | Screening Compounds and Building Blocks |
| N-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]nicotinamide (7290040) | |||
| ChemBridge特有类药化合物/先导化合物-7290040，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M46195 | ChemBridge-7649783 | ChemBridge化合物-7649783 | Screening Compounds and Building Blocks |
| 7-(difluoromethyl)-N-(2,3-dihydro-1H-inden-5-yl)-5-(4-methylphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide (7649783) | |||
| ChemBridge特有类药化合物/先导化合物-7649783，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M46282 | ChemBridge-7792734 | ChemBridge化合物-7792734 | Screening Compounds and Building Blocks |
| N-(4-sec-butylphenyl)-N'-[3-chloro-4-(difluoromethoxy)phenyl]thiourea (7792734) | |||
| ChemBridge特有类药化合物/先导化合物-7792734，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M46444 | ChemBridge-7947800 | ChemBridge化合物-7947800 | Screening Compounds and Building Blocks |
| 2-[(2-chloro-4,5-difluorobenzoyl)amino]-4-(3,4-dimethylphenyl)-3-thiophenecarboxamide (7947800) | |||
| ChemBridge特有类药化合物/先导化合物-7947800，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M46494 | ChemBridge-7974786 | ChemBridge化合物-7974786 | Screening Compounds and Building Blocks |
| 9-(2,5-difluorophenyl)-2,3,8,9-tetrahydro[1,4]dioxino[2,3-g]quinolin-7(6H)-one (7974786) | |||
| ChemBridge特有类药化合物/先导化合物-7974786，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M46509 | ChemBridge-7983139 | ChemBridge化合物-7983139 | Screening Compounds and Building Blocks |
| 8-{[7-(difluoromethyl)-5-(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]carbonyl}-1,4-dioxa-8-azaspiro[4.5]decane (7983139) | |||
| ChemBridge特有类药化合物/先导化合物-7983139，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M46543 | ChemBridge-8803897 | ChemBridge化合物-8803897 | Screening Compounds and Building Blocks |
| 5-(difluoromethyl)-1-(2-hydroxybenzoyl)-3-methyl-4,5-dihydro-1H-pyrazol-5-ol (8803897) | |||
| ChemBridge特有类药化合物/先导化合物-8803897，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M46630 | ChemBridge-8879055 | ChemBridge化合物-8879055 | Screening Compounds and Building Blocks |
| 2-{[5-(2,4-difluorophenyl)-2-furyl]methylene}-6,7,8,9-tetrahydro-5H-[1]benzothieno[3,2-e][1,3]thiazolo[3,2-a]pyrimidine-1,5(2H)-dione (8879055) | |||
| ChemBridge特有类药化合物/先导化合物-8879055，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M46694 | ChemBridge-8908049 | ChemBridge化合物-8908049 | Screening Compounds and Building Blocks |
| 3,5-bis(difluoromethyl)-1-{3-[(1-naphthyloxy)methyl]benzoyl}-4,5-dihydro-1H-pyrazol-5-ol (8908049) | |||
| ChemBridge特有类药化合物/先导化合物-8908049，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M46700 | ChemBridge-8910609 | ChemBridge化合物-8910609 | Screening Compounds and Building Blocks |
| N-(2,4-difluorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-5-isoxazolecarboxamide (8910609) | |||
| ChemBridge特有类药化合物/先导化合物-8910609，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M46715 | ChemBridge-8920928 | ChemBridge化合物-8920928 | Screening Compounds and Building Blocks |
| 4-(difluoromethyl)-1-(4-fluorophenyl)-6-(1-naphthyl)-1H-pyrazolo[3,4-b]pyridine (8920928) | |||
| ChemBridge特有类药化合物/先导化合物-8920928，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M46716 | ChemBridge-8920986 | ChemBridge化合物-8920986 | Screening Compounds and Building Blocks |
| 4-[4-(difluoromethyl)-3-methyl-6-(2-thienyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]benzoic acid (8920986) | |||
| ChemBridge特有类药化合物/先导化合物-8920986，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M46717 | ChemBridge-8920999 | ChemBridge化合物-8920999 | Screening Compounds and Building Blocks |
| 4-(difluoromethyl)-6-(3,4-dimethylphenyl)-1-[4-(4-methoxyphenyl)-6-(trifluoromethyl)-2-pyrimidinyl]-3-methyl-1H-pyrazolo[3,4-b]pyridine (8920999) | |||
| ChemBridge特有类药化合物/先导化合物-8920999，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M46718 | ChemBridge-8921003 | ChemBridge化合物-8921003 | Screening Compounds and Building Blocks |
| 6-(1,3-benzodioxol-5-yl)-4-(difluoromethyl)-1-[4-(4-methoxyphenyl)-6-(trifluoromethyl)-2-pyrimidinyl]-3-methyl-1H-pyrazolo[3,4-b]pyridine (8921003) | |||
| ChemBridge特有类药化合物/先导化合物-8921003，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M46719 | ChemBridge-8921101 | ChemBridge化合物-8921101 | Screening Compounds and Building Blocks |
| 1-(2-chlorobenzyl)-4-(difluoromethyl)-3-methyl-6-(1-naphthyl)-1H-pyrazolo[3,4-b]pyridine (8921101) | |||
| ChemBridge特有类药化合物/先导化合物-8921101，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M46755 | ChemBridge-9006483 | ChemBridge化合物-9006483 | Screening Compounds and Building Blocks |
| 5-chloro-N-[4-(difluoromethoxy)phenyl]-2-(propylsulfonyl)-4-pyrimidinecarboxamide (9006483) | |||
| ChemBridge特有类药化合物/先导化合物-9006483，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M47126 | ChemBridge-9272396 | ChemBridge化合物-9272396 | Screening Compounds and Building Blocks |
| N-(2,4-difluorophenyl)-3-(2-hydroxyphenyl)-5-isoxazolecarboxamide (9272396) | |||
| ChemBridge特有类药化合物/先导化合物-9272396，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M47179 | ChemBridge-9307560 | ChemBridge化合物-9307560 | Screening Compounds and Building Blocks |
| 1-tert-butyl-4-(2,4-difluorophenyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one (9307560) | |||
| ChemBridge特有类药化合物/先导化合物-9307560，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M47284 | ChemBridge-11521821 | ChemBridge化合物-11521821 | Screening Compounds and Building Blocks |
| N-(3,4-difluorophenyl)-1-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonyl)-3-piperidinamine (11521821) | |||
| ChemBridge特有类药化合物/先导化合物-11521821，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
M2198
|
Curcumin | 姜黄素 | Histone Acetyltransferase |
| Indian Saffron; Turmeric yellow; Natural Yellow 3; Diferuloylmethane | |||
| Curcumin (Diferuloylmethane，姜黄素)是一种天然酚类化合物，同时也是特异性的乙酰转移酶 p300/CREB 结合蛋白抑制剂，能抑制组蛋白/非组蛋白的乙酰化，以及组蛋白乙酰转移酶（histone acetyltransferase）依赖的染色质转录。此外，Curcumin 对 NF-κb 和 MAPKs 有抑制作用，并能通过 Keap1 半胱氨酸修饰诱导 Nrf2 蛋白的稳定。具有抗炎、抗氧化、抗增殖和抗血管生成活性。Curcumin 也是一种铜离子载体，可促进细胞对铜离子的摄取，它可以上调肠腺癌细胞中铜死亡相关蛋白并诱导其发生铜死亡。 | |||
| M4680
|
Rubimaillin | 大叶茜草素 | NF-κB |
| Mollugin 是 Rubia cordifolia L. 中主要的一种生物活性成分。Mollugin 通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。Mollugin 能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。 | |||
| M6820
|
Ancymidol | 嘧啶醇 | Plant growth regulators |
| EL-531; REDUCYMOL; THRITONE | |||
| Ancymidol（嘧啶醇）是一种嘧啶类化合物，也是DIF-3羟化酶的抑制剂，IC50为67 nM，此外，Ancymidol还可以抑制纤维素的形成。Ancymidol 是一种植物生长调节剂。 | |||
| M8767 | MIND4-17 | MIND4-17 | Others |
| MIND4-17 is a potent NRF2 (nuclear factor erythroid 2-related factor 2) activator that covalently modifies a critical stress-sensor cysteine (C151) in the BTB domain of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEAP1). | |||
| M10183
|
Difopein TFA | Difopein TFA | Peptides |
| Difopein TFA is a specific and competitive inhibitor of 14-3-3 protein, blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. | |||
| M10924
|
LY-3475070 | LY-3475070 | Immunology/Inflammation |
| LY-3475070 是首个口服生物可利用的、选择性的和胞外酶 CD73 (cluster of differentiation 73, 5'-ecto-nucleotidase, 5'-NT, ecto-5'-nucleotidase) 的抑制剂。 | |||
| M13517 | Polygalacin D | Polygalacin D | Apoptosis |
| Polygalacin D (PGD) 是从桔梗 Platycodon grandiflorum 中分离的具有抗癌和抗增殖特性的生物活性化合物。 Polygalacin D 抑制 IAP 蛋白家族的表达，包括存活蛋白，cIAP-1 和 cIAP-2 蛋白，并通过抑制 GSK3β，Akt 的磷酸化和PI3K 的表达来阻断 PI3K/Akt 途径。Polygalacin D 通过 PI3K/Akt 途径诱导凋亡 (apoptosis)。 | |||
| M13563
|
AC-73 | AC-73 | Autophagy |
| AC73 | |||
| AC-73 是 Cluster of Differentiation 147 (CD147) 的第一种特定的口服生物利用的抑制剂，可特异性破坏 CD147 的二聚化 (结合位点在 CD147 的 N 端 IgC2 域中包括 Glu64 和 Glu73)，从而抑制 CD147/ERK1/2/STAT3/MMP-2 途径，并抑制肝癌细胞的运动和侵袭。AC-73 还是一种抗增殖药，也是白血病细胞自噬的诱导剂。 | |||
| M14087 | Diflapolin | Diflapolin | Epoxide Hydrolase |
| Diflapolin 是一种高活性的双 5-脂氧合酶激活蛋白 (FLAP)/可溶性环氧化物水解酶 (sEH) 抑制剂，具有显著的抗炎作用和较高的靶向选择性。Diflapolin 抑制 IC50 分别为 30 和 170 nM 的完整人单核细胞和中性粒细胞中 5-LOX 产物的形成，并抑制分离的 sEH 的活性(IC50=20 nM)。 | |||
| M20864 | L-2-Hydroxyglutaric acid disodium | L-2-Hydroxyglutaric acid disodium | Histone demethylase |
| (S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG | |||
| L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively. | |||
| M22459
|
Recombinant Human EGF Protein (HEK293, hFc) | 重组人EGF蛋白 (HEK293, hFc) | Cytokines and Growth Factors |
| EGF is the founding member of the EGF-family of proteins. EGF is a growth factor that stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. It results in cellular proliferation, differentiation, and survival. Measured in a cell proliferation assay using Balb/C 3T3 mouse embryonic fibroblast cells, the ED50 for this effect is typically 0.3-1.5 ng/mL. | |||
| M22491
|
Recombinant Human C1QB Protein (Baculovirus-Insect, His Tag) | 重组人C1QB蛋白 (Baculovirus-Insect, His Tag) | Cytokines and Growth Factors |
| Complement Component 1, q subcomponent, B chain | |||
| Complement Component 1, q subcomponent (C1q) associates with C1r and C1s in order to yield the first component of the serum complement system. Sequence comparison of C1q from three different species have shown that the B chains have the strongest similarity. The recombinant human C1QB consists of 237 amino acids with the predicted molecular mass of 25.2 kDa. | |||
| M24791 | Denileukin diftitox | Denileukin diftitox | IL Receptor/Related |
| DAB 389IL-2; E7777; LY335348 | |||
| Denileukin diftitox (DAB 389IL-2) 是一种白喉毒素 (DT) 相关的白细胞介素 2 (IL-2) 融合蛋白毒素，可耗尽表达高亲和力形式的 IL-2 受体 (IL-2R)、CD25。Denileukin diftitox 与表达 IL-2R 的细胞结合并通过白喉毒素片段的内化抑制蛋白质合成。 | |||
| M27636 | CRS3123 | CRS3123 | Antibiotic |
| REP-3123 | |||
| CRS3123 是一种有效的具有口服活性的窄谱抗生素。CRS3123 抑制细菌甲硫氨酰-tRNA 合成酶。CRS3123 对艰难梭菌 (C. difficile) 和需氧革兰氏阳性菌具有有效活性，但对革兰氏阴性菌 (包括厌氧菌) 几乎没有活性。CRS3123具有研究艰难梭菌 (C. difficile) 感染的潜力。 | |||
| M27637 | CRS3123 dihydrochloride | CRS3123 dihydrochloride | Antibiotic |
| REP-3123 dihydrochloride | |||
| CRS3123 (REP-3123) dihydrochloride 是一种口服有效的全合成抗菌剂，可有效抑制 Clostridioides difficile 甲硫氨酰-tRNA合成酶 (MetRS)。CRS3123 dihydrochloride 可用于研究 Clostridioides difficile 感染 (CDI)。 | |||
| M39831 | H-Phe(3,5-DiF)-OH | H-Phe(3,5-DiF)-OH | Others |
| H-Phe(3,5-DiF)-OH 是一种 L 构型的二氟苯丙氨酸 [L-(F2)Phe]。H-Phe(3,5-DiF)-OH 可以结合到凝血酶受体栓系配体肽 SFLLRNP 中，以识别参与 CH/π 受体相互作用的 Phe-2 残基上的苯基氢。 | |||
| M55350
|
Recombinant Human IL-13 Protein (HEK293, C-Fc) | 重组人IL-13 蛋白 (HEK293, C-Fc) | Cytokines and Growth Factors |
| Interleukin-13 | |||
| Interleukin-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells.It is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. | |||
| M55669
|
Anti-Mouse IFNß (interferon beta) Antibody (Clone HDß-4A7) In vivo | Anti-Mouse IFNß (interferon beta) Antibody (Clone HDß-4A7) In vivo | Interferon-α/β/γ |
| IFN-b, IFN-beta, Type-1 interferon | |||
| Anti-Mouse Interferon-beta (IFN-ß) (Clone HDß-4A7) recognizes an epitope on Mouse IFN-ß and binds specifically to murine IFNß and does not bind murine IFNg or several different IFNa species (a-1,4,5 or 13); HDb-4A7 binds both recombinant and natural forms. | |||
| M55989 | SE-7552 | SE-7552 | HDAC |
| SE-7552 是 2-(difluoromethyl)-1,3,4-oxadiazole (DFMO) 衍生物，是一种具有口服活性的、高选择性、非异羟肟酸 HDAC6 抑制剂，IC50 为 33 nM。SE-7552 的选择性比所有其他已知的 HDAC 同工酶高 850 倍。 | |||
| M57745 | 6-bromo-2-(difluoromethyl)-3-fluoropyridine | 6-bromo-2-(difluoromethyl)-3-fluoropyridine | Others |
| 6-bromo-2-(difluoromethyl)-3-fluoropyridine | |||
