Anti-Mouse IFNß (interferon beta) Antibody (Clone HDß-4A7) In vivo 别名：IFN-b, IFN-beta, Type-1 interferon
Anti-Mouse Interferon-beta (IFN-ß) (Clone HDß-4A7) recognizes an epitope on Mouse IFN-ß and binds specifically to murine IFNß and does not bind murine IFNg or several different IFNa species (a-1,4,5 or 13); HDb-4A7 binds both recombinant and natural forms.
化学性质/溶解性/储存
| 储存条件 |
Stored sterile as received at 2-8°C for up to one month. |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
生物活性
Mouse Anti-Mouse Interferon-beta (IFN-ß) (Clone HDß-4A7) recognizes an epitope on Mouse IFN-ß and binds specifically to murine IFNß and does not bind murine IFNg or several different IFNa species (a-1,4,5 or 13); HDb-4A7 binds both recombinant and natural forms.
In Vitro Activity of HDß-4A7 - Inhibits IFNb-induced Stat1 phosphorylation (level of inhibition is similar to that seen using anti-IFNAR1 mAb (MAR1-5A3). Blocks IFNb induction of MHC-I expression (H2-Kb) using L929 or fibrosarcoma cell lines. Neutralizes IFNb-induced antiviral activity in vitro following infection of L929 cells with VSV.
In Vivo Activity of HDß-4A7 circulates with a half-life of ~ 14 days.
Blocks in vivo IFNb leading to increased the lethality of mice infected with West Nile Virus (WNV), similar to susceptibility of IFNb-/- mice.
Clone：HDß-4A7
Formulation：0.01 M (150 mM NaCl) PBS pH 7.2 - 7.4
Reactivity Species：Mouse
Host Species：Mouse
Product Concentration：≥ 5.0 mg/ml
Endotoxin：< 1.0 EU/mg
Purity：≥95%
实验参考
建议您制定动物给药及实验方案时，尽量参考已发表的相关实验文献（溶剂种类及配比众多，简单地溶解目的化合物，并不能解决动物给药依从性、体内生物利用度、组织分布等相关问题，未必能保证目的化合物在动物体内充分发挥生物学效用）。
体内实验的工作液，建议您现用现配，当天使用；如在配制过程中出现沉淀、析出现象，可以通过超声和（或）加热的方式助溶。
切勿一次性将产品全部溶解。
请在下面的计算器中，输入您的动物实验相关数据并点击计算，即可得到该实验的总需药量和工作液终浓度。
例如您给药剂量是10 mg/kg，平均每只动物的体重为20 g，每只动物的给药体积是100 μL，动物数量为20只，则该动物实验的总需药量为4 mg，工作液终浓度为2 mg/mL。
1：鉴于实验过程的损耗，建议您至少多配1-2只动物的量；
2：为该产品最终给药时的浓度。
其他相关的Interferon-α/β/γ产品
