找到约 30 条 “Antifungal” 相关结果 （用时 0.118 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M3953
|
Voriconazole | 伏立康唑 | Cytochrome P450 (e.g. CYP17) |
| UK-109496 | |||
| Voriconazole (UK-109496，伏立康唑) 是14α-羊毛甾醇脱甲基酶的抑制剂，IC50值为53nM。Voriconazole (UK-109496) 是广谱的三唑类抗真菌 (antifungal) 化合物，可抑制真菌麦角甾醇的生物合成。 | |||
| M5650
|
Fluconazole | 氟康唑 | Cytochrome P450 (e.g. CYP17) |
| UK 49858 | |||
| Fluconazole (UK-49858) 是一种三唑类抗真菌剂 (antifungal)，对多种真菌具有优异的活性，抑制 C. albicans 和 Candida kefyr 的 IC99为 0.20 μg/mL 至 0.39 μg/mL。Fluconazole 抑制 4 种烟曲霉菌，IC50 为 23.9-43.5 μg/mL。 | |||
| M7151 | Polygodial | 水蓼二醛 | Others |
| Polygodial is a tRPA1 channel activator; analgesic and antifungal. | |||
| M7893 | Leptomycin A | 来普霉素A | Others |
| Leptomycins are antifungal antibiotics with unique unsaturated, branched-chain fatty acid structures. | |||
| M8157 | Sordarin sodium salt | Sordarin sodium salt | Others |
| Sordarin is an antifungal metabolite possessing a tetracyclic diterpene glycoside structure. | |||
| M8588 | iKIX1 | iKIX1 | Others |
| iKIX1 is an antifungal agent that can re-sensitize drug-resistant Candida glabrata to azole antifungals. | |||
| M8592 | Brassinin | 芸苔宁 | Others |
| Brassinin is a phytoalexin isolated from cruciferous vegetables that exhibits anticancer, chemopreventive, antiproliferative and antifungal activities. | |||
| M8701 | Inz-1 | Inz-1 | Others |
| Inz-1 is a potent and selective inhibitor of yeast mitochondrial cytochrome bc1 that reverses resistance to triazole antifungals in the pathogenic fungus Candida albicans. | |||
| M9157
|
2-Phenylethyl isothiocyanate | 2-苯基乙基异硫代氰酸酯；异硫氰酸-2-苯基乙酯；异硫氰酸苯乙酯 | Antifungal |
| Isothiocyanic Acid 2-Phenylethyl Ester;2-PE ITC; PEITC | |||
| 2-Phenylethyl isothiocyanate是一种存在于豆瓣菜和十字花科蔬菜中的天然产物，同时也是有效的抗真菌剂 (antifungal)，能显著抑制互隔交链孢霉的孢子萌发和菌丝生长。此外，2-Phenylethyl isothiocyanate还能诱导自噬，同时抑制多种肿瘤细胞的生长。 | |||
| M11173 | PC945 | PC945 | Others |
| PC945 是一种有效的抗真菌 (antifungal) 三唑类药物，对多种敏感和耐药的烟曲霉菌株都具有抗药性。PC945 是烟曲霉甾醇 14α-去甲基酶 (CYP51A/CYP51B) 活性的有效、紧密结合的抑制剂，IC50s 分别为 0.23 μM 和 0.22 μM。 | |||
| M11174 | Mefentrifluconazole | 氯氟醚菌唑 | Others |
| Mefentrifluconazole 是一种新型的唑类衍生物，广谱抗真菌 (antifungal agent) 剂。Mefentrifluconazole 是具有强效选择性和口服活性真菌 CYP51 的抑制剂 (Kd= 0.5 nM)。 | |||
| M16987
|
Nyasol | 尼艾酚 | Anti-infection |
| Nyasol 尼艾酚 是一种具抗细菌 (antibacterial)、真抗菌 (antifungal)、抗利什曼原虫 (antileishmanial)、透明质酸酶 (hyaluronidase) 抑制活性的活性化合物。Nyasol 抑制 LTB4 与人中性粒细胞的结合。 | |||
| M17118 | Alternariol methyl ether | 交替烯醇甲醚；交链孢酚单甲醚 | Phenols |
| Alternariol methyl ether exhibits antifungal and phytotoxic activity. Alternariol methyl ether is a cholinesterase inhibitor. | |||
| M17299
|
Xanthoxylin | 花椒素；花椒油素 | Antifungal |
| Xanthoxyline | |||
| Xanthoxylin 花椒素具有抗真菌 (antifungal) 和抗癫痫活性。Xanthoxylin 是从 Zanthoxylum simulans 中分离出来的。 | |||
| M19162 | Cauloside A | 葳岩仙皂苷A | Antifungal |
| Cauloside A (Leontoside A) 是从 Dipsacus asper 根中分离出的皂苷。Cauloside A 具有有效的抗真菌 (antifungal) 活性。 | |||
| M20471 | Suloctidil | Suloctidil | Others |
| Suloctidil, a sulfur-containing aminoalcohol showing to inhibit human platelet aggregation, is a peripheral vasodilator and a potential antifungal agent. | |||
| M20789 | Neticonazole | Neticonazole | Others |
| SS717 | |||
| Neticonazole (SS717) is a selecvie inhibitor of exosome biogenesis and secretion. Neticonazole exhibits Neticonazole antifungal and antitumor activity. | |||
| M20895
|
Chlorobutanol | Chlorobutanol | Anti-infection |
| Chlorbutol, Chloreton, Chloretone, Chlortran| | |||
| Chlorobutanol (trichloro-2-methyl-2-propanol) is a preservative, sedative, hypnotic and weak local anesthetic with antibacterial and antifungal properties. | |||
| M20918 | Butoconazole | Butoconazole | Anti-infection |
| Butoconazole is an imidazole antifungal used in gynecology. | |||
| M20946 | Butenafine | Butenafine | Anti-infection |
| Butenafine is a synthetic benzylamine antifungal agent. | |||
| M20959 | Fosfluconazole | Fosfluconazole | Anti-infection |
| Fosfluconazole is a water-soluble phosphate prodrug of fluconazole, which is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. | |||
| M29194 | Fosmanogepix | Fosmanogepix | Antifungal |
| APX001; E1211 | |||
| Fosmanogepix (APX001) 是一种 N-磷酸氧基甲基前体化合物，能由全身碱性磷酸酶快速完全代谢为活性部分 APX001A，同时也是首创的（first-in-class）口服广谱抗真菌 (antifungal) 化合物，可靶向高度保守的 Gwt1 真菌酶。能用于侵袭性真菌感染的相关研究。 | |||
| M30976 | Swinholide A | Swinholide A | Antifungal |
| Swinholide A 是结合肌动蛋白的一种海洋聚酮化合物，可将肌动蛋白二聚化，Kd 约为 50 nM。Swinholide A 是一种破坏海洋毒素的微丝，可稳定肌动蛋白二聚体并切断肌动蛋白丝。Swinholide A 破坏细胞的肌动蛋白细胞骨架。具有抗真菌 (antifungal)活性。 | |||
| M38719 | L-Diguluronic acid | L-Diguluronic acid | Antifungal |
| L-Diguluronic acid 是一种由两个 L-guluronic acid (G) 组成的直链多糖共聚物，可用于海藻酸的合成。L-Diguluronic acid 是一种无支链聚阴离子多糖的总称，可用于抗真菌 (antifungal) 试剂的载体研究。 | |||
| M38723
|
Demethoxyencecalin | Demethoxyencecalin | Antifungal |
| Demethoxyencecalin 是从一种从向日葵中提取的色烯，具有抗真菌 (antifungal) 活性。 | |||
| M38731 | lsocryptomerin | lsocryptomerin | Antifungal |
| lsocryptomerin 是一种具有膜活性的抗真菌 (antifungal) 化合物，可从Selaginella tamariscina 中分离得到。lsocryptomerin 能使真菌质膜去极化。 | |||
| M38736 | 3-Oxobetulin | 3-Oxobetulin | Antifungal |
| 3-Oxobetulin 是一种抗真菌剂 (antifungal)，对白腐真菌 L. betulina 和 褐腐真菌 L. sulphureus 都具有抗真菌活性。 | |||
| M38742 | Eleutherol | 红葱酚 | Antifungal |
| Eleutherol 是从 E. americana 中分离得到的萘类化合物，具有抗真菌 (antifungal) 活性。Eleutherol 抑制白假丝酵母菌，白色念珠菌，酿酒酵母和新型隐球菌的 MIC 值在 7.8-250 µg/mL 之间。 | |||
| M53520 | Aminocandin | 氨基康定 | Antifungal |
| Aminocandin (HMR 3270) 是一种水溶性的棘白菌素类抗真菌剂 (antifungal)，对 Aspergillus 和 Candida spp. 具有良好的活性。 | |||
| M53847 | Iturin A | Iturin A | Antifungal |
| IturinA 对致病性酵母和真菌具有较强的抗真菌 (antifungal) 活性。 | |||
