找到约 54 条 “ALS” 相关结果 （用时 0.047 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M2429
|
Balsalazide disodium | 巴柳氮二钠 | Sirtuin |
| Balsalazide是一种抗炎化合物，用于研究炎症性肠病和溃疡性结肠炎。此外，Balsalazide也是Sirt5的抑制剂。 | |||
M3507
|
Valsartan | 缬沙坦 | Angiotensin Receptor |
| CGP 48933 | |||
| Valsartan是一种血管紧张素II受体（AT1R）拮抗剂，IC50在39.5到116 μM之间。 | |||
| M1606
|
Aluminum stearate | 硬脂酸铝 | Adjuvants |
| ALS; Tristearic acid aluminum salt | |||
| Aluminum stearate（硬脂酸铝）是一种无机佐剂（adjuvants），可用作药物赋形剂和内部释放调节剂，用于缓释药物的研究。 | |||
| M5444
|
Balsalazide | 巴柳氮 | IL Receptor/Related |
| Balsalazide (巴柳氮) 是抗炎化合物，可作用于炎症性肠病。 | |||
| M5731
|
LCZ696 | 沙库必曲/缬沙坦 | Angiotensin Receptor |
| Sacubitril/Valsartan；Entresto | |||
| LCZ696由Valsartan和Sacubitril以1：1的摩尔比组成，是一种首创(first-in-class)的双效血管紧张素受体-脑啡肽酶抑制剂（ARNi,angiotensin receptor-neprilysin inhibitor），用于研究高血压和心脏衰竭。 | |||
| M6267
|
Valspodar | 伐司扑达 | P-glycoprotein |
| PSC 833 | |||
| Valspodar 是一种 p-糖蛋白 (P-gp) 抑制剂，被广泛用作克服多药耐药性调节剂。 | |||
| M7245 | Salsolinol-1-carboxylic acid | Salsolinol-1-carboxylic acid | Others |
| Salsolinol-1-carboxylic acid is a endogenous amino acid. | |||
| M7352 | Talsupram hydrochloride | Talsupram hydrochloride | Others |
| Talsupram hydrochloride is a selective inhibitor of noradrenalin transporters. | |||
| M8326 | Salsolinol hydrobromide | 氢溴酸去甲猪毛菜碱 | Others |
| Salsolinol is the condensation product of acetaldehyde and dopamine. | |||
| M8799 | Talsaclidine | Talsaclidine | Others |
| Talsaclidine is a M1 selective muscarinic receptor agonist. | |||
| M9346
|
Pralsetinib | 普拉替尼 | RET |
| BLU-667 | |||
| Pralsetinib (Blu-667) 是新一代的，高效的，选择性RET抑制剂，对于WT RET，RET突变体V804L，V804M，M918T和CCDC6-RET的IC50为0.3-0.4 nM。 | |||
| M11406
|
Berotralstat | 贝罗司他 | Serine/Threonine Protease |
| Berotralstat (BCX7353) 是一种低毒性，有效，高特异性，第二代，具有口服活性的 plasma kallikrein 抑制剂，用于遗传性血管水肿 (hereditary angioedema，HAE) 的研究。 Berotralstat 通过阻断 plasma kallikrein 释放缓激肽的酶活性来发挥作用，缓激肽是促进与 HAE 发作相关的肿胀和疼痛的主要生物肽。 | |||
| M13594
|
Alsterpaullone | Alsterpaullone | CDK |
| 9-Nitropaullone; NSC 705701 | |||
| Alsterpaullone (9-Nitropaullone) 是一种高效的 CDK 抑制剂，作用于 CDK1/cyclin B、CDK2/cyclin A、CDK2/cyclin E 和 CDK5/p35 的 IC50 值分别为 35 nM、15 nM、200 nM 和 40 nM。 | |||
| M14532
|
Avoralstat | Avoralstat | Serine/Threonine Protease |
| BCX4161 | |||
| Avoralstat (BCX4161) 是一种有效的，具有口服活性的血浆激肽释放酶 (PKK) 抑制剂，用于研究遗传性血管性水肿。 | |||
| M16031
|
Tetrahydroalstonine | 四氢鸭脚木碱 | Adrenergic Receptor |
| Tetrahydroalstonine 四氢鸭脚木碱是一种选择性的 α2-肾上腺素受体拮抗剂。 | |||
| M16513 | Przewalskin | Przewalskin | Diterpenoids |
| Przewalskin | |||
| M17781 | Alstonic acid A | Alstonic acid A | Triterpenoids |
| Alstonic acid A | |||
| M17783 | Walsuralactam A | 割舌树内酰胺A | Triterpenoids |
| Walsuralactam A 割舌树内酰胺A | |||
| M18403 | Przewalskinic acid A | 甘西鼠尾草酸甲 | Others |
| Przewalskinic acid A 甘西鼠尾草酸甲 | |||
| M21530
|
Sebetralstat | Sebetralstat | Serine/Threonine Protease |
| KVD900 | |||
| Sebetralstat是一种具有口服活性的血浆激肽酶（KLKB1）抑制剂，可用于遗传性血管性水肿(HAE)的相关研究。 | |||
| M24953 | Balstilimab | 巴替利单抗 | PD-1/PD-L1 |
| AGEN2034 | |||
| Balstilimab (AGEN2034) 是一种针对 PD-1 的完全人单克隆 IgG4 抗体。 | |||
| M24994 | Palsucibep pegol | Palsucibep pegol | Others |
| Palsucibep pegol 是一种工程化的人类 lipocalin-2 结合蛋白。Palsucibep pegol 与 hepcidin 结合。 | |||
| M25051 | Alsevalimab | Alsevalimab | Others |
| Alsevalimab 是 B7-H4 的人类单克隆抗体。 | |||
| M28451 | ALS-8112 | ALS-8112 | RSV |
| ALS-8112是高效，选择性的呼吸道合胞病毒（RSV）聚合酶抑制剂。5'-三磷酸形式的ALS-8112抑制RSV聚合酶，IC50值为0.02 μM。 | |||
| M28905 | Berotralstat dihydrochloride | Berotralstat dihydrochloride | Serine/Threonine Protease |
| BCX7353 dihydrochloride | |||
| Berotralstat dihydrochloride 是一种低毒性，有效，高特异性，第二代，具有口服活性的 plasma kallikrein 抑制剂，用于遗传性血管水肿 (hereditary angioedema，HAE) 的研究。Berotralstat dihydrochloride 通过阻断 plasma kallikrein 释放缓激肽的酶活性来发挥作用，缓激肽是促进与 HAE 发作相关的肿胀和疼痛的主要生物肽。 | |||
| M29315 | Feniralstat | Feniralstat | Serine/Threonine Protease |
| Feniralstat 是吡唑衍生物，一种有效的激肽释放酶 (kallikrein) 抑制剂，对人血浆激肽释放酶 (pKal) 的 IC50 为 6.7 nM。Feniralstat 对人 KLK1、人 FXIa、人因子 Xlla 没有抑制作用 (IC50 均 >40 μM)。 | |||
| M29879 | ALS-I | ALS-I | Others |
| ALS-I，一种耐酸表面活性剂，用于溶液内酶消化，有助于溶解疏水性蛋白质。ALS-I 在再生大鼠视网膜和小鼠大脑的蛋白质组研究中，可显著提高质谱 (MS) 图谱的肽回收率。 | |||
| M30417 | Alstonine | Alstonine | Parasite |
| Alstonine 是一种植物性活性分子的主要吲哚生物碱化合物。Alstonine 具有抗精神病，抗焦虑，抗癌和抗疟疾的特性。 | |||
| M39167 | Uralsaponin D | Uralsaponin D | Phosphatase |
| Uralsaponin D 是一种可以从胀果甘草中分离出来的皂苷。Uralsaponin D 抑制磷脂酶 A2 (PLA2)，IC50 值为 32.2 μM。 | |||
| M40336 | Uralsaponin C | Uralsaponin C | Others |
| Uralsaponin C 是齐墩烷型三萜皂苷的类似物。Uralsaponin C 可从甘草的根中分离得到。 | |||
| M2962
|
Procyclidine hydrochloride | 丙环定盐酸盐 | GluR |
| (±)-Procyclidine hydrochlorid | |||
| Procyclidine hydrochloride blocks the effects of certain chemicals in the brain, and thus is used to treat Parkinson's disease or extrapyramidal side-effects caused by other medicines. | |||
| M2998
|
Sasapyrine | 双水杨酸酯 | ROS |
| Salicylsalicylic acid; Disalicylic acid | |||
| Sasapyrine（双水杨酸酯，Salsalate）是一种非甾体类抗炎剂和免疫调节剂，它可通过抑制环氧合酶（COX）的活性，减少炎症介质的生成。Sasapyrine还能够调节细胞的活性氧（ROS）水平，降低细胞的氧化应激。Sasapyrine可用于自身免疫疾病的研究。 | |||
| M55399
|
Recombinant Rat FGF-basic (E. coli, Ala11-Ser154) | 重组大鼠FGF-basic (E. coli, Ala11-Ser154) | Cytokines and Growth Factors |
| FGF-2; Fibroblast Growth Factor-basic; FGFb; bFGF | |||
| Fibroblast Growth Factor-basic (FGF-basic), also known as FGF-2, is a pleiotropic cytokine and one of the prototypic members of the heparin-binding FGF family. FGF-basic regulates a variety of processes including cell proliferation, differentiation, survival, adhesion, motility, apoptosis, limb formation and wound healing. FGF-basic is a non-glycosylated heparin binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland liver, monocytes, epithelial cells and endothelial cells. | |||
| M4305
|
Ganoderic-acid-A | 灵芝酸A | Apoptosis |
| Ganoderic-acid-A inhibits of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS. | |||
| M4452
|
Echinacoside | 松果菊苷；紫锥花苷；海胆苷；松果菊甙；紫锥菊苷 | Wnt/beta-catenin |
| Echinacoside 是从 Cistanche salsa 中分离得到的一种苯乙醇类化合物，有效抑制 Wnt/β-catenin 信号通路。Echinacoside 通过激活 Trk 受体及其下游信号通路而起到神经保护作用。Echinacoside 还具有显著的抗骨质疏松活性。 | |||
| M4714
|
Picrinine | 鸭脚树叶碱；灯以叶碱 | Lipoxygenase |
| Picrinine 是一种从 Alstonia scholaris 的叶子中分离出来的 Akuammiline 生物碱。Picrinine 通过抑制5-脂氧合酶表现出抗炎活性。 | |||
| M6001
|
Terbuthylazine | 特丁津 | Others |
| Terbuthylazine是一种乙酰乳酸合酶 (ALS) 抑制剂, 是一种选择性除草剂 | |||
| M6471
|
Astemizole | 阿司咪唑 | Histamine Receptor |
| Astemizole is a orally active, potent H 1 antagonist. Also K V11.1 (hERG) channel blocker. | |||
| M6615
|
Clemizole hydrochloride | 盐酸克立咪唑；克立咪唑盐酸；盐酸氯咪唑 | Histamine Receptor |
| Clemizole hydrochloride is a tRPC5 blocker; also H 1 antagonist. | |||
| M6639 | Cyanopindolol hemifumarate | Cyanopindolol hemifumarate | Others |
| Cyanopindolol hemifumarate is a 5-HT1A/1B antagonist with roughly equal affinity at each receptor; also a β-adrenoceptor antagonist. | |||
| M6651 | Damnacanthal | 丹宁卡；丹拿堪索 | Others |
| Damnacanthal is a potent, selective p56 lck inhibitor; also LIMK1/2 inhibitor. | |||
| M6658 | DCG IV | DCG IV | Others |
| DCG IV is a very potent, selective group II mGlu agonist. Also NMDA agonist. | |||
| M6698 | Edelfosine | Edelfosine | Others |
| Edelfosine is a selective PI-PLC inhibitor, also PAF receptor agonist. | |||
| M6721 | ETP 45658 | ETP 45658 | Others |
| ETP 45658 is a potent PI 3-kinase inhibitor; also inhibits DNA-PK and mTOR. | |||
| M6774 | GSK 789472 hydrochloride | GSK 789472 hydrochloride | Others |
| GSK 789472 hydrochloride is a d 3 antagonist. Also D 2 partial agonist. | |||
| M6806 | IC 87201 | IC 87201 | Others |
| IC 87201 is a nNOS-PSD95 protein-protein interaction inhibitor; also antinociceptive and antidepressant. | |||
| M6818 | Ifenprodil hemitartrate | 艾芬地尔 | Others |
| Ifenprodil hemitartrate is a non-competitive NMDA antagonist. Also σ ligand. | |||
| M6950 | Mesulergine hydrochloride | Mesulergine hydrochloride | Others |
| Mesulergine hydrochloride is a 5-HT 2A and 5-HT 2C antagonist. Also dopamine receptor partial agonist. | |||
| M7011 | NADA | NADA | Others |
| NADA is a endogenous CB 1 agonist. Also vanilloid agonist and inhibitor of FAAH and AMT. | |||
| M7093 | OXSI 2 | OXSI 2 | Others |
| OXSI 2 is a potent Syk kinase inhibitor; also inhibits assembly of NLRP3 inflammasomes. | |||
| M7120 | PF 06465469 | PF 06465469 | Others |
| PF 06465469 is a potent ITK inhibitor; also inhibits BTK. | |||
| M7213 | Roxindole hydrochloride | Roxindole hydrochloride | Others |
| Roxindole hydrochloride is a dopamine D 2 autoreceptor agonist. Also has affinity for D 3, D 4, 5-HT 1A receptors and the 5-HT transporter. | |||
| M7235 | Ryuvidine | Ryuvidine | Others |
| Ryuvidine is a sETD8 inhibitor; also CDK4 inhibitor. | |||
| M7269 | SB 747651A dihydrochloride | SB 747651A dihydrochloride | Others |
| SB 747651A dihydrochloride is a potent MSK1 inhibitor; also inhibits other AGC group kinases. | |||
