找到约 7 条 “TGF-β Receptor” 相关结果 （用时 0.645 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M1980
|
LY2157299 (Galunisertib) | LY2157299 (Galunisertib) | TGF-β Receptor |
| Galunisertib | |||
| LY2157299 (Galunisertib)是有效的TGFβ receptor I (TβRI)抑制剂，IC50为56 nM。 | |||
| M2081
|
LY2109761 | LY2109761 | TGF-β Receptor |
| LY-2109761 | |||
| LY2109761是一种新型的，选择性的TGF-β receptor type I/II (TβRI/II)双重抑制剂，Ki分别为38 nM和300 nM，对Smad2的磷酸化产生负面影响。 | |||
| M2108
|
SB-525334 | SB-525334 | TGF-β Receptor |
| SB525334是一种有效的，选择性的TGFβ receptor I (ALK5)抑制剂，IC50为14.3 nM，作用于ALK4比作用于ALK5效果低4倍，可抑制ALK2， 3，和6活性。 | |||
M5246
|
EW-7197 | EW-7197 | TGF-β Receptor |
| Vactosertib; TEW-7197 | |||
| EW-7197是一种高效的，选择性的，口服生物有效的TGF-β receptor ALK4/ALK5抑制剂，IC50分别为13 nM 和 11 nM。 | |||
| M29975 | SB-505124 hydrochloride | SB-505124 hydrochloride | TGF-β Receptor |
| SB-505124 hydrochloride 是一种选择性的 TGF-β Receptor type I receptor (ALK4，ALK5，ALK7) 抑制剂，对 LK4，ALK5 的 IC50 值分别为 129 nM 和 47 nM，对 ALK1，2，3 或 6 无作用。 | |||
| M55622
|
Recombinant Human BMPRIA/ALK-3/CD292 Protein (HEK293, C-His) | 重组人BMPRIA/ALK-3/CD292 蛋白 (HEK293, C-His) | Cytokines and Growth Factors |
| Bone Morphogenetic Protein Receptor type IA; Activin receptor-Like Kinase 3; ACVRLK3 | |||
| BMPR1A/ALK-3/CD292 protein is expressed in the epithelium during branching morphogenesis. It is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta (TGF-β) superfamily. BMPR1A/ALK-3 plays an essential role in the formation of embryonic ventral abdominal wall, and abrogation of BMP signaling activity due to gene mutations in its signaling components could be one of the underlying causes of omphalocele at birth. The type IA BMP receptor, ALK-3 was specifically required at mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum, and endocardial cushion. | |||
| M58453
|
Recombinant Human BMP-6 (E.coli, C-His) | 重组人BMP-6 (E.coli, C-His) | Cytokines and Growth Factors |
| Bone Morphogenetic Protein-6 | |||
| Bone Morphogenetic Protein-6 (BMP-6) is an extracellular multifunctional cytokine that is also a member of the TGF-β family. BMP-6 can bind with the TGF-β receptor and triggers SMAD protein signal transduction. It plays a vital role in regulating hepcidin to maintain iron ions in the body. | |||
