找到约 11 条 “SF 11” 相关结果 （用时 0.107 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M1925
|
LY294002 | LY294002 | PI3K |
| NSC 697286; SF 1101 | |||
| LY294002是一种广谱的PI3K抑制剂，对PI3Kα/δ/β的IC50分别为0.5 μM/0.57 μM/0.97 μM。LY294002 也可以抑制 CK2 的活性，IC50 为 98 nM。LY294002 还是一种竞争性 DNA-PK 抑制剂，可逆结合 DNA-PK 的激酶结构域，IC50 为 1.4 μM。 | |||
M3007
|
SF1126 | SF1126 | PI3K |
| SF1126 是RGDS-缀合的 LY294002 前体，同时也是首创的（first-in-class）双重 PI3K/BRD4 泛抑制剂，具有抗肿瘤和抗血管生成活性。并能诱导细胞凋亡 (apoptosis)。 | |||
| M7289 | SF 11 | SF 11 | Neuropeptide Receptor |
| SF 11是一种NPY Y2受体拮抗剂。 | |||
| M15095
|
Recombinant Mouse RANKL (HEK293, N-6His) | 重组小鼠RANKL蛋白 (HEK293, N-6His) | Cytokines and Growth Factors |
| Tnfsf11 | |||
| Recombinant Mouse RANKL/TNFSF11 is a member of the tumor necrosis factor (TNF) cytokine family. Tnfsf11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune response and enhancing bone-resorption in humoral hypercalcemia of malignancy. It augments the ability of dendritic cells to stimulate naive T-cell proliferation. | |||
| M55293
|
Recombinant Mouse RANKL (E. coli) | 重组小鼠RANKL (E. coli) | Cytokines and Growth Factors |
| TNFSF11 | |||
| 小鼠肿瘤坏死因子配体超家族成员11(RANKL/TNFSF11)是肿瘤坏死因子(TNF)细胞因子家族成员。RANKL/TNFSF11广泛表达于包括T细胞在内的细胞以及T细胞丰富的器官，如胸腺和淋巴结。该细胞因子可与TNFRSF11B/OPG和tnfrsf11a /RANK结合。Tnfsf11参与许多基本的生物学过程，如作为t细胞和树突状细胞之间相互作用的调节剂，调节t细胞依赖的免疫反应和增强恶性体液高钙血症中的骨吸收。它增强了树突细胞刺激幼稚t细胞增殖的能力。 | |||
| M1696
|
Cediranib | 西地尼布 | VEGFR/PDGFR |
| AZD2171; NSC-732208 | |||
| Cediranib (AZD2171)是一种高效的VEGFR(KDR)抑制剂，IC50为<1 nM，同时也抑制Flt1/4，IC50为5 nM/≤3 nM，此外对c-Kit和PDGFRβ也具有相似的抑制活性，对VEGFR的选择性比PDGFR-α， CSF-1R和Flt3分别高36倍， 110倍 和1000倍以上。 | |||
| M8984
|
Denosumab | 地舒单抗；地诺单抗 | NF-κB |
| AMG 162,Anti-RANK ligand | |||
| Denosumab是一种靶向NF-κB受体活化因子配体RANKL的全人源单克隆抗体，能结合并抑制 RANKL 受体激活因子 (TNFSF11)，具有抗癌活性。 | |||
| M40926
|
Recombinant Human/Mouse/Rat GDF-11 Protein (HEK293) | 重组人/小鼠/大鼠GDF-11蛋白 (HEK293) | Cytokines and Growth Factors |
| Growth/differentiation factor 11; BMP-11 | |||
| Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. | |||
| M20771 | RP-64477 | RP-64477 | Others |
| RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). RP-64477 inhibits ACAT activity with IC50 of 113 nM, 503 nM, and 180 nM in human intestinal (CaCo-2), hepatic (HepG2) and monocytic (THP-1) cell assays, respectively. | |||
| M29174 | CHMFL-ABL/KIT-155 | CHMFL-ABL/KIT-155 | Src-bcr-Abl |
| CHMFL-ABL-KIT-155 | |||
| CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; compound 34) 是一种高效的，具有口服活性的 type II ABL/c-KIT 双激酶抑制剂 (IC50 分别为 46 nM 和 75 nM)，对 BLK (IC50=81 nM), CSF1R (IC50=227 nM), DDR1 (IC50=116 nM), DDR2 (IC50=325 nM), LCK (IC50=12 nM), PDGFRβ (IC50=80 nM) 激酶也具有明显的抑制活性。 | |||
| M30111 | ABT-100 | ABT-100 | Farnesyl Transferase |
| ABT-100 是一种有效的，高选择性和口服活性的 farnesyltransferase 抑制剂。ABT-100 抑制细胞增殖 (对于 EJ-1，DLD-1，MDA-MB-231，HCT-116，MiaPaCa-2，PC-3 和 DU-145 细胞的 IC50 分别为 2.2 nM，3.8 nM，5.9 nM，6.9 nM，9.2 nM，70 nM 和 818 nM)，可增加细胞凋亡并减少血管生成。ABT-100 具有广谱抗肿瘤活性。 | |||
