找到约 20 条 “NG25” 相关结果 （用时 0.108 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M9342
|
NG25 | NG25 | MAPKAPK2/MAP3K/MAP4K |
| NG25是一种TAK1和MAP4K2的双重抑制剂，对应的IC50值分别为149 nM和21.7 nM。 | |||
| M25429
|
Rezafungin acetate | 雷扎芬净醋酸盐；醋酸瑞扎芬净；醋酸雷扎芬净 | Anti-infection |
| Biafungin acetate; CD101 acetate; SP-3025 acetate | |||
| Rezafungin（CD101，雷扎芬净）醋酸盐是一种新型的棘白菌素类抗真菌环肽，能抑制真菌合成细胞壁所必须的1,3-β-glucan synthase（葡聚糖合成酶），对念珠菌，曲霉和肺孢子菌等有抑制活性。 | |||
| M51345 | Fibronectin Type III Connecting Segment Fragment 1-25 | Fibronectin Type III Connecting Segment Fragment 1-25 | Others |
| Fibronectin Type III Connecting Segment Fragment 1-25 是一种负责黑色素瘤细胞粘附的多肽，在鸡周围神经系统的发育中发挥着重要作用。 | |||
| M4356
|
β-Mangostin | β-倒捻子素 | Antibiotic |
| beta-Mangostin (β-Mangostin) 是存在 Cratoxylum arborescens 中的一种氧杂蒽酮化合物，具有抗菌和抗疟疾活性。beta-Mangostin 对结核分枝杆菌作用的 MIC 值为 6.25 μg/mL。beta-Mangostin 具有体外抗疟活性，对恶性疟原虫作用的 IC50 值为 3.00 μg/mL。beta-Mangostin 对各种癌症 (如肝细胞癌、白血病) 具有强大的抗癌活性。 | |||
| M6404
|
Acridine Orange hydrochloride | 吖啶橙AO染液 | Fluorescent Dye |
| 吖啶橙(Acridine Orange，AO) 是一种荧光染料，主要用于染色区分核苷酸分子。Acridine Orange与正常的DNA结合时发绿色荧光（Ex = 488，Em = 525 nm），而与RNA或者单链DNA结合时发橙色荧光（Ex = 488，Em = 640 nm）。Acridine Orange还可用于染色病毒、寄生虫以及机体组织。 | |||
| M13908
|
AVE 0991 sodium salt | AVE 0991 sodium salt | Angiotensin Receptor |
| AVE 0991 sodium salt 是一种有效的非肽Ang-(1-7) 受体 Mas 激动剂。AVE 0991 sodium salt 与 [125I]-Ang-(1-7) 竞争性地结合到牛主动脉内皮细胞膜，IC50 为 21 nM。 | |||
| M20606 | SAR125844 | SAR125844 | c-Met |
| SAR125844 is a potent intravenously active and highly selective MET kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively). | |||
| M20613
|
PF-CBP1 HCl | PF-CBP1 HCl | Epigenetic Reader Domain |
| PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively. | |||
| M22491
|
Recombinant Human C1QB Protein (Baculovirus-Insect, His Tag) | 重组人C1QB蛋白 (Baculovirus-Insect, His Tag) | Cytokines and Growth Factors |
| Complement Component 1, q subcomponent, B chain | |||
| Complement Component 1, q subcomponent (C1q) associates with C1r and C1s in order to yield the first component of the serum complement system. Sequence comparison of C1q from three different species have shown that the B chains have the strongest similarity. The recombinant human C1QB consists of 237 amino acids with the predicted molecular mass of 25.2 kDa. | |||
| M38707 | Questin | Questin | Antibiotic |
| Questin 是从海洋黄曲霉中分离出来的一种抗菌剂。Questin对 V. harveyi，V. anguillarum，V. cholerae 和 V. parahemolyticus 具有抗菌活性，MIC 值分别为 31.25 µg/mL，62.5 µg/mL，62.5 µg/mL 和 125 µg/mL。 | |||
| M38742 | Eleutherol | 红葱酚 | Antifungal |
| Eleutherol 是从 E. americana 中分离得到的萘类化合物，具有抗真菌 (antifungal) 活性。Eleutherol 抑制白假丝酵母菌，白色念珠菌，酿酒酵母和新型隐球菌的 MIC 值在 7.8-250 µg/mL 之间。 | |||
| M41232
|
Quinacrine | Quinacrine | Parasite |
| Quinacrine（Acriquine）是一种具有多种生物活性的小分子化合物， Quinacrine具有较强的抗疟疾活性，它通过嵌入疟原虫 DNA，抑制其核酸合成和转录，干扰疟原虫的生长繁殖。Quinacrine还可通过激活线粒体凋亡通路、抑制DNA复制等方式抑制肿瘤的生长。Quinacrine还是一种染料，其分子结构中的吖啶环（Acridine Ring）是典型的荧光发色团，Quinacrine可用于DNA或者RNA的染色 （Ex/Em = 436/525 nm）。 | |||
| M49483 | B-355252 | B-355252 | Apoptosis |
| B-355252是一种苯氧基噻吩磺酰胺小分子，同时也是有效的 NGF 受体激动剂，能增强 NGF 诱导的神经突生长。同时能通过减轻 DNA 损伤、减少 ROS 产生和 LDH 水平以及防止神经元凋亡来保护缺血性神经元免受神经元损失。此外，B355252 还能在谷氨酸诱导的兴奋性毒性以及帕金森病 (PD) 的小鼠海马细胞系 (HT22) 模型中具有抗凋亡作用。 | |||
| M54740
|
6-Methoxynaringenin | 6-甲氧基柚皮素 | NO Synthase |
| 6-Methoxynaringenin 是一种天然黄酮类化合物，可抑制 NO 产生，IC50 为 25.8 μM。 | |||
| M55381
|
Recombinant Human IL-25/IL-17E (HEK293, C-6His) | 重组人IL-25/IL-17E (HEK293, C-6His) | Cytokines and Growth Factors |
| Interleukin-25; Interleukin-17E | |||
| Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins. IL25 is a glycoprotein secreted as dimers by innate effector eosinophils and basophils, and present at very low levels in various peripheral tissues. IL25, together with IL17B, are ligands for the cytokine receptor IL17BR, and the cross-linking induces NF-κB activation and production of the proinflammatory chemokine IL-8, as well as ERK, JNK, and p38 activation. | |||
| M55382
|
Recombinant Human IL-25/IL-17E (E. coli, C-His) | 重组人IL-25/IL-17E (E. coli, C-His) | Cytokines and Growth Factors |
| Interleukin-25; Interleukin-17E | |||
| Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins. IL25 is a glycoprotein secreted as dimers by innate effector eosinophils and basophils, and present at very low levels in various peripheral tissues. IL25, together with IL17B, are ligands for the cytokine receptor IL17BR, and the cross-linking induces NF-κB activation and production of the proinflammatory chemokine IL-8, as well as ERK, JNK, and p38 activation. | |||
| M56520 | Dimethylamiloride hydrochloride | Dimethylamiloride hydrochloride | Na+/H+ Exchanger (NHE) |
| Dimethylamiloride hydrochloride 是一种 Na+/H+ exchanger NHE 抑制剂，对 NHE1，NHE2 和 NHE3 的 Ki 值分别为 0.02，0.25 和 14 μM。Dimethylamiloride hydrochloride 可用于炎症性疼痛研究。 | |||
| M58404 | Rosoxacin | 罗索沙星 | Antibiotic |
| Acrosoxacin | |||
| Rosoxacin (Acrosoxacin，罗索沙星) 是一种口服有效的，具有广谱抗菌活性的喹诺酮类抗生素。Rosoxacin 具有广谱的抗菌活性，抑制革兰氏阴性菌，包括淋病奈瑟氏球菌 (MIC range=0.03-0.125 µg/mL)。 | |||
| M58425
|
Acridine Orange | 吖啶橙 | Fluorescent Dye |
| Acridine Orange（吖啶橙）是一种荧光染料，主要用于染色区分核苷酸分子。Acridine Orange与正常的DNA结合时发绿色荧光（Ex = 488，Em = 525 nm），而与RNA或者单链DNA结合时发橙色荧光（Ex = 488，Em = 640 nm）。Acridine Orange还可用于染色病毒、寄生虫以及机体组织。 | |||
| M58432
|
Anti-Mouse RANKL/CD254 Antibody (Clone 7C6) In vivo | Anti-Mouse RANKL/CD254 Antibody (Clone 7C6) In vivo | NF-κB |
| Anti-Mouse RANKL/CD254 Antibody (Clone 7C6) is a Mouse-derived VHH-mFc type antibody, targeting to mouse RANKL/CD254. | |||
