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 找到约 59 条 “IOX1” 相关结果 (用时 0.049 秒)

目录号 产品名称 中文名称 靶点
M2057 Dexrazoxane hydrochloride 盐酸右雷佐生;右雷佐生盐酸盐;右丙亚胺盐酸盐;右雷唑烷盐酸盐 Topoisomerase
Cardioxane, ICRF-187, NSC169780, Zinecard,DXZ
Dexrazoxane HCl (ICRF-187, ADR-529,DXZ)是一种铁螯合剂,也可以靶向抑制拓扑异构酶2α(Topoisomerase 2α)。能用于预防DOX诱导的心脏毒性。
M6831 IOX1 IOX1 Histone demethylase
IOX-1
IOX1是一个2OG oxygenases强效的广谱抑制剂,对KDM4A和KDM3A的IC50值分别为0.6 uM和0.1 uM。IOX1也抑制ALKBH5。
M11603 ChemBridge-5106399 ChemBridge化合物-5106399 Screening Compounds and Building Blocks
methyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-butynoate (5106399)
ChemBridge特有类药化合物/先导化合物-5106399,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11615 ChemBridge-5109057 ChemBridge化合物-5109057 Screening Compounds and Building Blocks
2-{[1-(4-bromophenyl)-2,5-dioxo-3-pyrrolidinyl]thio}-N-2-naphthylacetamide (5109057)
ChemBridge特有类药化合物/先导化合物-5109057,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11621 ChemBridge-5112759 ChemBridge化合物-5112759 Screening Compounds and Building Blocks
1-(2-furylmethylene)-6-methyl-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-one (5112759)
ChemBridge特有类药化合物/先导化合物-5112759,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11629 ChemBridge-5114006 ChemBridge化合物-5114006 Screening Compounds and Building Blocks
ethyl 3-(benzylamino)-2-(3-chloro-1,4-dioxo-1,4-dihydro-2-naphthalenyl)-3-phenylacrylate (5114006)
ChemBridge特有类药化合物/先导化合物-5114006,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11634 ChemBridge-5115805 ChemBridge化合物-5115805 Screening Compounds and Building Blocks
ethyl 1-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-2-oxocyclopentanecarboxylate (5115805)
ChemBridge特有类药化合物/先导化合物-5115805,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11635 ChemBridge-5115807 ChemBridge化合物-5115807 Screening Compounds and Building Blocks
5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone (5115807)
ChemBridge特有类药化合物/先导化合物-5115807,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11641 ChemBridge-5118173 ChemBridge化合物-5118173 Screening Compounds and Building Blocks
3-(1,4-dioxaspiro[4.5]dec-2-ylmethyl)-2-isopropyl-1,3-oxazolidine (5118173)
ChemBridge特有类药化合物/先导化合物-5118173,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11668 ChemBridge-5133193 ChemBridge化合物-5133193 Screening Compounds and Building Blocks
4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid (5133193)
ChemBridge特有类药化合物/先导化合物-5133193,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11676 ChemBridge-5135600 ChemBridge化合物-5135600 Screening Compounds and Building Blocks
9,10-dioxo-N-phenyl-9,10-dihydro-2-anthracenesulfonamide (5135600)
ChemBridge特有类药化合物/先导化合物-5135600,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11691 ChemBridge-5140203 ChemBridge化合物-5140203 Screening Compounds and Building Blocks
4-nitrophenyl (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetate (5140203)
ChemBridge特有类药化合物/先导化合物-5140203,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11692 ChemBridge-5140317 ChemBridge化合物-5140317 Screening Compounds and Building Blocks
2-(5-benzylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)-3-methylbutanoic acid (5140317)
ChemBridge特有类药化合物/先导化合物-5140317,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11693 ChemBridge-5140589 ChemBridge化合物-5140589 Screening Compounds and Building Blocks
3-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-oxo-4H-chromen-7-yl hexopyranoside (5140589)
ChemBridge特有类药化合物/先导化合物-5140589,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11697 ChemBridge-5141565 ChemBridge化合物-5141565 Screening Compounds and Building Blocks
4-amino-1-[6-(hydroxymethyl)-2-oxidotetrahydrofuro[3,4-d][1,3,2]dioxathiol-4-yl]-2(1H)-pyrimidinone hydrochloride (5141565)
ChemBridge特有类药化合物/先导化合物-5141565,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11710 ChemBridge-5143717 ChemBridge化合物-5143717 Screening Compounds and Building Blocks
5-{[5-(2,5-dichlorophenyl)-2-furyl]methylene}-3-methyl-2-thioxo-1,3-thiazolidin-4-one (5143717)
ChemBridge特有类药化合物/先导化合物-5143717,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11715 ChemBridge-5146442 ChemBridge化合物-5146442 Screening Compounds and Building Blocks
2,2'-{(4,4'-dioxo-2,2'-dithioxo-5,5'-bi-1,3-thiazolidine-3,3'-diyl)bis[(1-oxo-3,1-propanediyl)imino]}dibenzoic acid (5146442)
ChemBridge特有类药化合物/先导化合物-5146442,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11719 ChemBridge-5148440 ChemBridge化合物-5148440 Screening Compounds and Building Blocks
5-(4-chlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (5148440)
ChemBridge特有类药化合物/先导化合物-5148440,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11720 ChemBridge-5149378 ChemBridge化合物-5149378 Screening Compounds and Building Blocks
N-(5-chloro-2-pyridinyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinesulfonamide (5149378)
ChemBridge特有类药化合物/先导化合物-5149378,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11721 ChemBridge-5149498 ChemBridge化合物-5149498 Screening Compounds and Building Blocks
3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(2-hydroxyphenyl)propanamide (5149498)
ChemBridge特有类药化合物/先导化合物-5149498,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11723 ChemBridge-5149715 ChemBridge化合物-5149715 Screening Compounds and Building Blocks
4-methyl-2-oxo-2H-chromen-7-yl {[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-4-oxo-4H-chromen-7-yl]oxy}acetate (5149715)
ChemBridge特有类药化合物/先导化合物-5149715,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11745 ChemBridge-5158496 ChemBridge化合物-5158496 Screening Compounds and Building Blocks
sodium 4-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)butanoate (5158496)
ChemBridge特有类药化合物/先导化合物-5158496,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11746 ChemBridge-5158497 ChemBridge化合物-5158497 Screening Compounds and Building Blocks
4-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxybutanamide (5158497)
ChemBridge特有类药化合物/先导化合物-5158497,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11748 ChemBridge-5158906 ChemBridge化合物-5158906 Screening Compounds and Building Blocks
3-allyl-5-(2-furylmethylene)-2-thioxo-1,3-thiazolidin-4-one (5158906)
ChemBridge特有类药化合物/先导化合物-5158906,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11749 ChemBridge-5160780 ChemBridge化合物-5160780 Screening Compounds and Building Blocks
2-[5-(4-nitrophenoxy)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]benzoic acid (5160780)
ChemBridge特有类药化合物/先导化合物-5160780,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11751 ChemBridge-5161874 ChemBridge化合物-5161874 Screening Compounds and Building Blocks
3-ethyl-5-(1-methyl-2(1H)-pyridinylidene)-2-thioxo-1,3-thiazolidin-4-one (5161874)
ChemBridge特有类药化合物/先导化合物-5161874,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11752 ChemBridge-5162044 ChemBridge化合物-5162044 Screening Compounds and Building Blocks
5-(2-nitrobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (5162044)
ChemBridge特有类药化合物/先导化合物-5162044,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11757 ChemBridge-5170837 ChemBridge化合物-5170837 Screening Compounds and Building Blocks
5-(3,4-dihydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one (5170837)
ChemBridge特有类药化合物/先导化合物-5170837,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11758 ChemBridge-5171838 ChemBridge化合物-5171838 Screening Compounds and Building Blocks
2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylic acid -2-ethyl-3,9-dimethyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-4-amine (1:1) (5171838)
ChemBridge特有类药化合物/先导化合物-5171838,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M11780 ChemBridge-5176187 ChemBridge化合物-5176187 Screening Compounds and Building Blocks
1,3-dioxo-2-(2-pyrimidinyl)-5-isoindolinecarboxylic acid (5176187)
ChemBridge特有类药化合物/先导化合物-5176187,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。
M2134 Vortioxetine hydrobromide 溴酸沃替西汀;氢溴酸沃泰西汀;沃替西汀氢溴酸 5-HT Receptor
Lu AA21004
Vortioxetine (Lu AA21004) HBr是一种5-羟色胺抑制剂,抑制5-HT1A, 5-HT1B, 5-HT3A, 5-HT7受体和SERT,IC50分别为15 nM, 33 nM, 3.7 nM, 19 nM和1.6 nM。
M2573 IOX2 IOX2 HIF
IOX2是一种有效的HIF-1α prolyl hydroxylase-2 (PHD2)(HIF-1α脯氨酰羟化酶-2)抑制剂,IC50为21 nM,比作用于JMJD2A, JMJD2C, JMJD2E, JMJD3和2OG氧合酶FIH选择性高100倍以上。
M2862 MNS MNS Src-bcr-Abl
NSC 170724; 5-(2-Nitrovinyl)benzodioxole
MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)是一种酪氨酸激酶抑制剂,抑制Syk, Src和p97, IC50分别为2.5 μM, 29.3 μM和1.7 μM。此外,MNS还能通过抑制NLRP3,从而抑制泛凋亡(PANoptosis)。
M43895 tert-butyl 4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidine-1-carboxylate 4-(4-((2,6-二氧代哌啶-3-基)氨基)苯基)哌啶-1-甲酸叔丁酯 Ligand for E3 Ligase
1-Piperidinecarboxylic acid, 4-[4-[(2,6-dioxo-3-piperidinyl)amino]phenyl]-, 1,1-dimethylethyl ester
tert-butyl 4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidine-1-carboxylate
M3305 Tioxolone 噻克索酮 Carbonic Anhydrase
Tioxolone是一种金属酶碳酸酐酶I抑制剂,Ki为91 nM。
M4943 3,4,5-Trimethoxyphenylacetic acid 3,4,5-Trimethoxyphenylacetic acid Metabolite/Endogenous Metabolite
Cell suspensions did not release carbon dioxide from 3,4-[methoxyl-14C]dihydroxy-5-methoxyphenylacetate but accumulated 1 mol of methanol per mol of 3,4,5-trimethoxyphenylacetate oxidized.
M6058 Vortioxetine 沃替西汀 5-HT Receptor
Lu AA 21004
Vortioxetine (沃替西汀; Lu AA21004) 对5-HT1A,5-HT1B,5-HT3A,5-HT7受体和SERT的IC50分别为15 nM,33 nM,3.7 nM,19 nM和1.6 nM。
M8395 REDD1 inducer REDD1 inducer Others
6-(1,3- dioxo -6-(piperidin-1-yl)- 1h -benzo[de]isoquinolin-2(3H)-yl)hexanoic acid是一种流感病毒毒力因子NS1的抑制剂,通过激活宿主mTORC1抑制剂REDD1的表达(调控发育和DNA损伤反应)。
M10799 BMS-986242 BMS-986242 IDO
BMS-986242 是一种具有口服活性、强效和选择性的 indoleamine-2,3-dioxygenase 1 (IDO1) 抑制剂。BMS-986242 可用于癌症研究。
M11006 IOX4 IOX4 HIF
IOX4 是一种选择性 PHD2 抑制剂,IC50 值为 1.6 nM,在细胞和野生型小鼠中诱导 HIFα 表达,可通透血脑屏障。IOX4 与 PHD2 活性位点的 2-氧代戊二酸 (2OG) 竞争并置换。
M14107 D-α-Hydroxyglutaric acid disodium (R)-2-羟基戊二酸二钠盐 ROS
Disodium (R)-2-hydroxyglutarate
D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate,(R)-2-羟基戊二酸二钠盐) 是神经代谢疾病 D-2-羟基戊二酸尿症中积累的主要代谢产物,也是 α-酮戊二酸 (α-KG) 的弱竞争拮抗剂,可抑制多种 α-KG 依赖性双加氧酶 (dioxygenases),Ki 为 10.87 mM。此外,D-α-Hydroxyglutaric acid disodium也可增加活性氧 (ROS) 的产生。
M16349 9β,13β-Epidioxyabiet-8(14)-en-18-oic acid 9β,13β-Epidioxyabiet-8(14)-en-18-oic acid Diterpenoids
9β,13β-Epidioxyabiet-8(14)-en-18-oic acid
M16993 2-(2,2-Dimethyl-1,3-dioxolan -4-yl)propane-1,2-diol 2-(2,2-Dimethyl-1,3-dioxolan -4-yl)propane-1,2-diol Others
2-(2,2-Dimethyl-1,3-dioxolan -4-yl)propane-1,2-diol
M20575 Lucanthone Lucanthone Autophagy
Lucanthone is a novel autophagic inhibitor and also an orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1.
M27893 Antioxidant agent-10  Antioxidant agent-10  Others
Antioxidant agent-10 (Compound 3) 是一种具有中等 DPPH 清除活性的抗氧化剂,EC50 为 33.2 μg/mL。
M28559 (R)-FL118 (R)-FL118 Others
10,11-(Methylenedioxy)-20(R)-camptothecin
(R)-FL118 (10,11-(Methylenedioxy)-20(R)-camptothecin) 是 FL118 的 R 型异构体。(R)-FL118 具有抗癌 (anticancer) 活性。
M29484 IDO-IN-13  IDO-IN-13  IDO
IDO-IN-13 是一种有效的 indoleamine 2,3-dioxygenase 1 (IDO1) 抑制剂,EC50 值为 17 nM,详细信息请参考 WO2019040102A1,example 43。
M43876 1,1-Dimethylethyl 6-(2,6-dioxo-3-piperidinyl)-3,4-dihydro-2(1H)-isoquinolinecarboxylate 1,1-Dimethylethyl 6-(2,6-dioxo-3-piperidinyl)-3,4-dihydro-2(1H)-isoquinolinecarboxylate Ligand for E3 Ligase
1,1-Dimethylethyl 6-(2,6-dioxo-3-piperidinyl)-3,4-dihydro-2(1H)-isoquinolinecarboxylate
M29809 NU223612  NU223612  PROTAC
NU223612 是一种有效的 PROTAC (PROTACs),可降解吲哚胺 2,3-双加氧酶 1 (IDO1) (Indoleamine 2,3-Dioxygenase (IDO)),Kd 为 640 nM。NU223612 通过 CRBN 介导的蛋白酶体降解有效降解 IDO1 蛋白。NU223612 以 290 nM 的亲和力与 CRBN 结合。NU223612 可以穿过血脑屏障 (BBB)。
M29860 5-Bromo-5-nitro-1,3-dioxane 5-溴-5-硝基-1,3-二噁烷 Antibiotic
5-Bromo-5-nitro-1,3-dioxane 是一种抗菌化合物,可有效对抗革兰氏阳性和革兰氏阴性细菌和真菌,包括酵母。5-Bromo-5-nitro-1,3-dioxane 通过必需蛋白硫醇的氧化抑制酶活性并随后抑制微生物的生长。
M30730 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol Apoptosis
9,11-Dehydroergosterol peroxide; 9(11)-DHEP
5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide),一种来自药用蘑菇的重要甾体,对几种肿瘤类型具有抗肿瘤活性。5,8-Epidioxyergosta-6,9(11),22-trien-3-ol 通过诱导 CDKN1A 表达抑制 HT29 细胞生长,从而导致细胞周期停滞和凋亡。
M38771 1,4-Epidioxybisabola-2,10-dien-9-one 1,4-Epidioxybisabola-2,10-dien-9-one Anti-infection
1,4-Epidioxybisabola-2,10-dien-9-one 是 1,4-epidioxy-bisabola-2,12-diene 的衍生物,可从 Curcuma longa L. 中分离出来。1,4-Epidioxybisabola-2,10-dien-9-one 在 MDCK 细胞系中表现出抗流感病毒 A/PR/8/34 (H1N1) 的抗病毒活性,IC50 为 16.79 ± 4.03 μg/mL。
M41161 Helioxanthin Helioxanthin Anti-infection
Helioxanthin (ACH126447) 具有体外抗病毒活性,对HBV的EC50为1 μM,还可抗黄病毒。
M41897 RTIOXA-43 RTIOXA-43 OX Receptor
RTIOXA-43 是一种食欲素受体 (orexin receptor) 激动剂,对于 OX2 和 OX1 受体的 EC50 值均为 24 nM。
M43861 4-Piperidinecarboxylic acid, 1-[5-(2,6-dioxo-3-piperidinyl)-2-pyridinyl]-, 1,1-dimethylethyl ester 4-Piperidinecarboxylic acid, 1-[5-(2,6-dioxo-3-piperidinyl)-2-pyridinyl]-, 1,1-dimethylethyl ester Ligand for E3 Ligase
4-Piperidinecarboxylic acid, 1-[5-(2,6-dioxo-3-piperidinyl)-2-pyridinyl]-, 1,1-dimethylethyl ester
M43874 4-[3-(2,6-Dioxo-3-piperidinyl)-1-methyl-1H-indazol-6-yl]-3,3-difluoro-1-piperidineacetic acid 4-[3-(2,6-Dioxo-3-piperidinyl)-1-methyl-1H-indazol-6-yl]-3,3-difluoro-1-piperidineacetic acid Ligand for E3 Ligase
4-[3-(2,6-Dioxo-3-piperidinyl)-1-methyl-1H-indazol-6-yl]-3,3-difluoro-1-piperidineacetic acid
M43881 1-[4-(Tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)phenyl]-3-pyrrolidinecarboxaldehyde 1-[4-(Tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)phenyl]-3-pyrrolidinecarboxaldehyde Ligand for E3 Ligase
1-[4-(Tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)phenyl]-3-pyrrolidinecarboxaldehyde
M43882 1-(4-(2,4-Dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperidine-4-carbaldehyde 1-(4-(2,4-二氧代四氢嘧啶-1(2H)-基)苯基)哌啶-4-甲醛 Ligand for E3 Ligase
4-Piperidinecarboxaldehyde, 1-[4-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)phenyl]-
1-(4-(2,4-Dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperidine-4-carbaldehyde
M43884 1-[4-(Tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)phenyl]-4-piperidinecarboxylic acid 1-[4-(Tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)phenyl]-4-piperidinecarboxylic acid Ligand for E3 Ligase
1-[4-(Tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)phenyl]-4-piperidinecarboxylic acid









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