找到约 9 条 “Histone Methyltransferase” 相关结果 （用时 0.19 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M2024
|
BIX 01294 Trihydrochloride | BIX 01294 Trihydrochloride | Histone Methyltransferase |
| BIX 01294是一种组蛋白甲基转移酶（G9ahistone methyltransferase）抑制剂，IC50为2.7 μM，降低组蛋白H3K9me2，也微弱抑制GLP（主要是H3K9me3），对其他组蛋白甲基转移酶没有显著的抑制活性。此外，BIX-01294可用于小鼠多能干细胞的诱导和维持。 | |||
| M7509
|
UNC0642 | UNC0642 | Histone Methyltransferase |
| UNC0642是一种有效的、选择性的histone methyltransferases G9a/GLP抑制剂，对G9a和GLP的IC50均小于2.5 nM。对G9a和GLP的选择性比其他激酶、GPCRs、转运体和离子通道高300倍以上。 | |||
| M8989
|
BIX-01294 | BIX-01294 | Histone Methyltransferase |
| BIX-01294 是一种有效的G9a甲基转移酶 (G9a Histone Methyltransferase) 抑制剂，IC50 值为 1.9 μM。此外，BIX-01294可用于小鼠多能干细胞的诱导和维持。BIX-01294 可诱导坏死性凋亡 (necroptosis) 和自噬。 | |||
| M20492 | AMI-1, free acid | AMI-1, free acid | Histone Methyltransferase |
| AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively. | |||
| M21329
|
Histone H2A (1-20) | Histone H2A (1-20) | Peptides |
| Histone H2A (1-20) 是一种含 35 个氨基酸的组蛋白 H2A 肽片段，是甲基转移酶/脱甲基酶 (methyltransferase/demethylase enzymes) 的底物。序列：Ser-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Ala-Arg-Ala-Lys-Ala-Lys-Thr-Arg-Ser-Ser-Arg。 | |||
| M38950 | Tanshindiol C | 丹参二醇C | Histone Methyltransferase |
| Tanshindiol C 是一种 S-腺苷甲硫氨酸竞争性 EZH2 (Histone Methyltransferase) 抑制剂，抑制甲基转移酶活性的 IC50 为 0.55 μM。Tanshindiol C 也是巨噬细胞中 Nrf2 和 Sirtuin 1 (Sirt1) 的激活剂。 | |||
| M41483 | cis-BG47 | cis-BG47 | HDAC |
| cis-BG47 是 BG47 的顺式异构体，BG47 是一种典型的组蛋白脱乙酰酶 HDAC1 或 HDAC2 选择性光表观遗传学探针，在光诱导的反式-顺式异构化时能与 HDAC 靶点结合并竞争性抑制其脱乙酰酶活性，增加组蛋白甲基转移酶 (Histone Methyltransferase) H3K9 乙酰化。 | |||
| M58788
|
Recombinant Human Menin (E.Coli/BV) | 重组人Menin (E.Coli/BV) | Target Proteins |
| Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). | |||
| M58923
|
Recombinant Human SUV39H1 (E.coli) | 重组人SUV39H1 (E.coli) | Target Proteins |
| Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. | |||
