Cholesterol - 搜索结果 | AbMole中文官网

找到约 31 条 “Cholesterol” 相关结果（用时 0.097 秒）

目录号	产品名称	中文名称	靶点
M2516	Cholesterol	胆固醇	Estrogen Receptor
	Cholesterol是一种哺乳动物中的主要固醇，占质膜结构成分的 20-25％，并在确定膜的流动性和渗透性特征以及转运蛋白和信号蛋白的功能中起着重要作用。此外，Cholesterol 还是一种内源性雌激素相关受体 α (ERRα) 激动剂。
M9313	25-Hydroxycholesterol	25-Hydroxycholesterol	Others
	25-Hydroxycholesterol 是胆固醇的代谢产物，由巨噬细胞响应 Toll 样受体 (TLR) 激活而产生和分泌。25-Hydroxycholesterol 有效且选择性抑制 B 细胞产生 IgA，EC50 约为 65 nM。
M10348	27-Hydroxycholesterol	27-羟基胆固醇	Estrogen Receptor
	27-Hydroxycholesterol是一种选择性的雌激素受体 (estrogen receptor) 调节剂，它也是一种肝脏X受体 (liver X receptor) 的激动剂。
M13771	BODIPY-Cholesterol	BODIPY-Cholesterol	Fluorescent Dye
	BODIPY-cholesterol 是一种带有荧光 BODIPY 基团的亲脂性和细胞通透性胆固醇类似物。BODIPY-cholesterol 可用于监测细胞内固醇摄取和细胞器间固醇通量。(激发/发射波长: 480/508 nm)。
M18170	7-Dehydrocholesterol acetate	7-脱氢胆固醇乙酸酯	Others
	7-Dehydrocholesterol acetate 7-脱氢胆固醇乙酸酯
M18253	7alpha-Hydroxycholesterol	7-羟基胆固醇	Others
	7α-Hydroxycholesterol 是一种胆固醇氧化物，由酶促氧化和非酶促氧化形成。
M18414	7-Dehydrocholesterol	7-去氢胆固醇；7-脱氢胆固醇	Ferroptosis
	7-DHC
	7-Dehydrocholesterol（7-DHC，7-去氢胆固醇）是一种胆固醇合成过程中的代谢中间体，同时也是不饱和甾醇，其甾醇B环上的共轭双键可以使7-DHC吸收自由基，从而抵消自由基触发脂质氧化和铁死亡的能力。
M20876	Dihydrocholesterol	Dihydrocholesterol	Others
	Beta-Cholestanol, Zymostanol, 5alpha-Cholestanol
	Dihydrocholesterol is a cholesterol derivative found in human feces, gallstones, eggs, and other biological matter.
M21702	22(R)-Hydroxycholesterol	22(R)-羟基胆固醇	Metabolite/Endogenous Metabolite
	22(R)-Hydroxycholesterol是从胆固醇合成孕烯醇酮途径中的一种中间体。它具有神经保护特性并可保护神经元免受β-淀粉样蛋白诱导的细胞死亡。
M21968	Cholesterol Margarate	十七酸胆固醇酯	Others
	Cholesterol Margarate
M22127	Cholesterol-d7	Cholesterol-d7	Others
	Cholesterol-d7
M28685	Cholesterol 24-hydroxylase-IN-1	Cholesterol 24-hydroxylase-IN-1	Cytochrome P450 (e.g. CYP17)
	Cholesterol 24-hydroxylase-IN-1 (compound 17) 是一种强效、口服活性和高选择性的胆固醇24-羟化酶 (CH24H or CYP46A1) 抑制剂 (IC50=8.5 nM)。Cholesterol 24-hydroxylase-IN-1 能透过血脑屏障。
M28783	DC-Chol hydrochloride	DC-Chol hydrochloride	Amyloid
	DC-Cholesterol hydrochloride
	DC-Chol hydrochloride 在适当的实验条件下能抑制 Aβ40 纤维的形成。DC-Chol hydrochloride 以剂量依赖性的方式强烈抑制氧化hCT的淀粉样蛋白形成。
M30042	Cholesterol 5beta,6beta-epoxide	Cholesterol 5beta,6beta-epoxide	Others
	Cholesterol beta-epoxide
	Cholesterol 5beta,6beta-epoxide 是胆固醇的一种氧化代谢物，通过胆固醇在 5,6 双键处的自由基和非自由基氧化形成。在巨噬细胞分化的 U937 细胞中诱导乳酸脱氢酶 (LDH) 的释放和细胞凋亡。
M30136	24-Methylenecholesterol	24-Methylenecholesterol	Transferase
	Ostreasterol
	24-Methylenecholesterol (Ostreasterol) 是一种天然海洋甾醇，可刺激人类巨噬细胞中的胆固醇酰基转移酶 (cholesterol acyltransferase)。24-Methylenecholesterol 在酵母中具有抗衰老作用。24-Methylenecholesterol 可延长蜜蜂寿命并改善育幼蜂生理。
M30137	24(S)-Hydroxycholesterol	24(S)-Hydroxycholesterol	Liver X Receptor
	24S-OHC; 24S-HC; Cerebrosterol
	24(S)-Hydroxycholesterol (24S-OHC) 是脑胆固醇的主要代谢物，对维持脑内胆固醇的稳态起主要作用。24(S)-Hydroxycholesterol (24S-OHC) 是非常有效的内源性的 LXR 的激动剂，在大脑和循环系统中含量高。24(S)-Hydroxycholesterol (24S-OHC) 是有效直接的、选择性的NMDARs 的阳性变构调节剂，其机制不会与其它异构调节因子重叠。
M30428	7α,25-Dihydroxycholesterol	7α,25-Dihydroxycholesterol	GPR/FFAR
	7α, 25-dihydroxycholesterol (7α,25-OHC) 是一种孤儿 GPCR 受体 EBI2 (GPR183) 的有效选择性激动剂和内源性配体。7α, 25-dihydroxycholesterol 对激活 EBI2 有很强的作用 (EC50=140 pM; Kd=450 pM)。7α, 25-dihydroxycholesterol 可作为一种趋化因子，指导 B 细胞、T 细胞和树突状细胞的迁移。
M39576	Cholesterol 5α,6α-epoxide	Cholesterol 5α,6α-epoxide	Others
	Cholesterol-5α,6α-epoxide 是一种生化试剂，可作为生物材料或有机化合物，用于生命科学相关研究。
M39737	7β-Hydroxycholesterol	7β-Hydroxycholesterol	Others
	7β-Hydroxycholesterol 是一种通过胆固醇氧化得到的氧固醇。7β-Hydroxycholesterol 是一种强大的氧化应激诱导剂，可诱导细胞器 (线粒体、溶酶体和过氧化物酶体) 功能障碍，从而导致细胞死亡。
M6474	AY 9944 dihydrochloride	AY 9944 dihydrochloride	Hedgehog
	ay9944二盐酸盐是hedgehog (Hh)信号通路的抑制剂，可能通过几种机制。抑制Δ7-dehydrocholesterol还原酶(IC50 = 13 nM)，从而减少胆固醇的生物合成，也抑制胆固醇酯化。也可能直接阻断细胞对Hh蛋白的反应。产生畸形的体内。
M7653	BM 15766 sulfate	BM 15766 sulfate	Others
	Dehydrocholesterol reductase inhibitor.
M7772	Diethylumbelliferyl phosphate	Diethylumbelliferyl phosphate	Others
	Diethylumbelliferyl phosphate is a selective, potent cholesterol esterase inhibitor.
M8202	Sandoz 58-035	Sandoz 58-035	Others
	Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
M8694	K-604	K-604	Others
	K-604 inhibits against acyl-coenzyme A (acyl-CoA):cholesterol O-acyltransferase-1 (ACAT1, SOAT1) activitiy in a selective (IC₅₀ = 450 nM vs.
M8757	TASIN-1 hydrochloride	TASIN-1 hydrochloride	Others
	TASIN-1 (Truncated APC Selective INhibitor-1) targets EBP- (Emopamil-binding protein; D8-D7 sterol isomerase) dependent cholesterol biosynthesis and selectively induces cellular cholesterol depletion and apoptotic death in human colorectal cancer (CRC).
M8836	U 18666A	U 18666A	Others
	Inhibitor of cholesterol synthesis (inhibits desmosterol Δ24-reductase).
M18321	5-Cholesten-3β-ol-7-one	5-胆甾烯-3β-醇-7-酮	Metabolite/Endogenous Metabolite
	7-Ketocholesterol 毒性羟甾醇，抑制胆汁酸生物合成的限速步骤胆固醇 7 α -羟化酶，并强烈抑制 HMG-CoA 还原酶 (胆固醇生物合成的限速酶)。
M20771	RP-64477	RP-64477	Others
	RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). RP-64477 inhibits ACAT activity with IC50 of 113 nM, 503 nM, and 180 nM in human intestinal (CaCo-2), hepatic (HepG2) and monocytic (THP-1) cell assays, respectively.
M20994	Eicosapentaenoic acid ethyl ester	Eicosapentaenoic acid ethyl ester	FAS
	AMR101, EPA ethyl ester, Ethyl eicosapentaenoate
	Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels.
M21184	Soticlestat	Soticlestat	Cytochrome P450 (e.g. CYP17)
	TAK-935; OV935
	Soticlestat (TAK-935; OV935) 是一种首创的(first-in-class)，有效的，选择性的，具有口服活性的胆固醇 24-羟化酶 (cholesterol 24-hydroxylase, CH24H) 抑制剂。Soticlestat 可用于癫痫综合征的研究。
M21547	Recombinant Mouse PCSK9 (Mammalian, C-6His)	重组小鼠PCSK9 蛋白(Mammalian, C-6His)	Recombinant Proteins
	Proprotein Convertase Subtilisin/Kexin Type 9
	Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in neural development.

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