找到约 32 条 “CY2-SE” 相关结果 （用时 0.099 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
| M31319 | CY2-SE | CY2-SE | Fluorescent Dye |
| Cyanine2 Succinimidyl Ester | |||
| CY2-SE (Cyanine2 Succinimidyl Ester) 是一种用于标记肽, 蛋白质, 寡核苷酸的氨基基团的染料（λex=492 nm， λem=510 nm）。 | |||
| M51403 | (Cys(Acm)6, 12)-Orexin A (human, mouse, rat) | (Cys(Acm)6, 12)-Orexin A (human, mouse, rat) | Others |
| (Cys(Acm)6,12)-Orexin A (human, mouse, rat) 是一种多肽，能够由多肽筛选发现。 | |||
M58226
|
Recombinant Human CDK2 (E.coli-S) | 重组人 CDK2 (E.coli-S) | Cytokines and Growth Factors |
| Cyclin-Dependent Kinase 2; Cell Division Protein Kinase 2 | |||
| CDK2 是一种重要的丝氨酸/苏氨酸蛋白激酶，在细胞周期中发挥着关键的调节作用，在减数分裂中发挥着不可或缺的作用，但对于有丝分裂来说却是可有可无的。 | |||
| M40957
|
Recombinant Human IL-22 Protein (HEK293) | 重组人IL-22蛋白 (HEK293) | Cytokines and Growth Factors |
| Interleukin-22 | |||
| Interleukin-22(IL-22) belongs to a group of cytokines called the IL-10 family or IL-10 superfamily. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens in epithelial cells such as those in the lung and gut. | |||
| M6642 | CYM 50260 | CYM 50260 | S1P Receptor |
| CYM 50260 is a potent and selective S1P4 agonist. | |||
| M6643
|
CYM 5520 | CYM 5520 | S1P Receptor |
| CYM 5520 is a selective S1P2 allosteric agonist. | |||
| M7763
|
Diacylglycerol Kinase Inhibitor I | Diacylglycerol Kinase Inhibitor I | 5-HT Receptor |
| R 59-022; DKGI-I | |||
| Diacylglycerol Kinase Inhibitor I（R 59-022）是一种二酰甘油激酶（DGK）和5-HT Receptor的抑制剂，作用于DGK的IC50值为2.8 µM，并能抑制 OAG 磷酸化为 OAPA。此外，Diacylglycerol Kinase Inhibitor I也能激活蛋白激酶 C (PKC)。 | |||
| M7953 | NKY80 | NKY80 | Others |
| NKY80 is a selective adenylyl cyclase-V inhibitor with greater than 200-fold selectivity for type V over the type II isoform. | |||
| M10277
|
EN6 | EN6 | Autophagy |
| ABM-4739 | |||
| EN6 是一种基于共价丙烯酰胺的，小分子的体内自噬（autophagy）激活剂，可共价靶向溶酶体液泡 H+ATP 酶 (v-ATPase) ATP6V1A 亚基中的半胱氨酸 277(Cys277)。能通过共价修饰v-ATP酶，破坏Ragulator-RagGTPase复合物，从而导致mTORC1失活，增加溶酶体的酸化，最终使自噬通量增强而诱导自噬。 | |||
| M10673
|
Procyanidin C1 | 原花青素C1 | Apoptosis |
| PCC1 | |||
| Procyanidin C1 (PCC1) 是一种天然多酚，可造成 DNA 损伤，细胞周期停滞，诱导凋亡 (apoptosis)。Procyanidin C1 降低癌细胞中 Bcl-2 的蛋白水平，增强 BAX，caspase 3 和 9 的表达。 | |||
| M55325
|
Recombinant Human IL-29/IFN-λ1 (HEK293, C-10His) | 重组人IL-29/IFN-λ1 (HEK293, C-10His) | Cytokines and Growth Factors |
| Interleukin-29; Interferon lambda-1; IFN-lambda-1 | |||
| Interleukin-29 (IL-29; IFN-λ1) is a cytokine with immunomodulatory activity. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL-29 may play a role in antiviral immunity. | |||
| M14194
|
Cyclopiazonic acid | 环二氮酸 | Calcium Channel |
| Cyclopiazonic acid (CPA) 是一种源于 A. flavus 的神经毒性次级代谢产物 (SM)，是一种纳摩尔内质网钙 ATP 酶抑制剂 (Ca2+ATPase; SERCA)，是植物细胞死亡的有效诱导剂。 | |||
| M20389 | Quisinostat (JNJ-26481585) 2HCl | Quisinostat (JNJ-26481585) 2HCl | HDAC |
| Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11 greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2. | |||
| M20706 | HQNO | HQNO | Others |
| 2-heptyl-4-hydroxyquinoline-N-oxide | |||
| HQNO is a natural quinolone secreted by P. aeruginosa. HQNO is a potent inhibitor of the electron transport chain with Kd of 64 nM for the ubiquinol-ferricytochrome c oxidoreductase segment (Complex III) of the respiratory chain. HQNO is also an inhibitor of bacterial and mitochondrialType II NADH : quinone oxidoreductase (NDH-2) with IC50 of 7.3 μM in the presence of 50μM menadione. | |||
| M20862 | BCH | BCH | Others |
| 2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, LAT1-IN-1 | |||
| BCH (2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, LAT1-IN-1) is a selective and competitive inhibitor of system L amino acid transporter 1 (LAT1). BCH (LAT1-IN-1) induces apoptosis in cancer cells. | |||
| M21402
|
Recombinant Mouse IL-27 (HEK293, C-6His) | 重组小鼠IL-27 蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
| Interleukin-27 subunit alpha; IL-27 subunit alpha | |||
| IL-27 is a heterodimeric cytokine which belongs to the IL-6/IL-12 family of long type I cytokines. Recombinant Mouse Interleukin-27 Subunit Alpha and Interleukin-27 Subunit Beta expressed the target gene encoding Tyr19-Pro228&Phe29-Ser234 with a 6His tag at the C-terminus. | |||
| M24702 | Indusatumab | Indusatumab | Others |
| 5F9 Monoclonal antibody | |||
| Indusatumab (5F9 Monoclonal antibody) 是一种 anti-human GUCY2C (Guanylate cyclase 2C) 的单克隆抗体。 | |||
| M25383
|
Recombinant Human KEAP1 Protein (Baculovirus-Insect) | 重组人KEAP1蛋白 (Baculovirus-Insect) | Cytokines and Growth Factors |
| Kelch-like ECH-associated protein 1; INRF2 | |||
| Kelch-like ECH-associated protein 1 (KEAP1) is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB (POZ) domain, and six Kelch repeats. KEAP1 is a key regulator of the NRF2 transcription factor, which transactivates the antioxidant response element (ARE) and upregulates numerous proteins involved in antioxidant defense. | |||
| M25384
|
Recombinant Human KEAP1 Protein (Baculovirus-Insect, His & GST Tag) | 重组人KEAP1蛋白 (Baculovirus-Insect, His & GST Tag) | Cytokines and Growth Factors |
| Kelch-like ECH-associated protein 1; INRF2 | |||
| Kelch-like ECH-associated protein 1 (KEAP1) is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB (POZ) domain, and six Kelch repeats. KEAP1 is a key regulator of the NRF2 transcription factor, which transactivates the antioxidant response element (ARE) and upregulates numerous proteins involved in antioxidant defense. | |||
| M25427
|
Recombinant Human SDF-1 Protein (E. coli) | 重组人SDF-1蛋白 (E. coli) | Cytokines and Growth Factors |
| Stromal cell-derived factor-1 | |||
| The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF-1 binds primarily to CXC receptor 4 (CXCR4; CD184). The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription. | |||
| M25536
|
Recombinant Human CXCL13/BCA-1 (E. coli) | 重组人CXCL13/BCA-1蛋白 (E. coli) | Cytokines and Growth Factors |
| CXC chemokine BLC; Small-inducible cytokine B13 | |||
| CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Recombinant human CXCL13 is a single non-glycosylated polypeptide chain containing 87 amino acids and mature human BCA-1 shares 64 % amino acid sequence similarity with the murine protein and 23–34 % amino acid sequence identity with other known CXC chemokines. Determined by a chemotaxis bioassay using human B cells, the biological activity is in a concentration range of 1.0-10 ng/ml. | |||
| M27921 | BI 653048 | BI 653048 | GCR |
| BI 653048 是一种选择性且口服的非甾体类糖皮质激素 (glucocorticoid (GC)) 激动剂，其 IC50 值为 55 nM。BI 653048 抑制 CP1A2，CYP2D6，CYP2C9，CYP2C19 和 CYP3A4 的活性并降低对 hERG 离子通道的亲和力 (IC50>30 μM)。BI 653048 也是一种 HCV NS3 protease 抑制剂，可以减少感染丙型肝炎病毒的病毒载量。 | |||
| M27922 | BI 653048 phosphate | BI 653048 phosphate | GCR |
| BI 653048 phosphate 是一种选择性且口服的非甾体类糖皮质激素 (glucocorticoid (GC)) 激动剂，其 IC50 值为 55 nM。BI 653048 phosphate 抑制 CP1A2，CYP2D6，CYP2C9，CYP2C19 和 CYP3A4 的活性并降低对 hERG 离子通道的亲和力 (IC50>30 μM)。BI 653048 phosphate 也是一种 HCV NS3 protease 抑制剂。 | |||
| M28118 | Cyclotheonamide A | Cyclotheonamide A | Serine/Threonine Protease |
| Cyclotheonamide A 是一种丝氨酸蛋白酶 (serine protease) 抑制剂 (环状多肽)，可从 Theonella 属的海洋海绵中获得。Cyclotheonamide A 对 trypsin (Ki=0.023 µM) 和 streptokinase (Ki=0.035 µM) 显示强效的抑制活性，对人 α-thrombin (Ki=0.18 µM) 显示中等抑制活性。Cyclotheonamide A 可用于抗血栓的研究。 | |||
| M28685 | Cholesterol 24-hydroxylase-IN-1 | Cholesterol 24-hydroxylase-IN-1 | Cytochrome P450 (e.g. CYP17) |
| Cholesterol 24-hydroxylase-IN-1 (compound 17) 是一种强效、口服活性和高选择性的胆固醇24-羟化酶 (CH24H or CYP46A1) 抑制剂 (IC50=8.5 nM)。Cholesterol 24-hydroxylase-IN-1 能透过血脑屏障。 | |||
| M31176
|
Recombinant Human CD40L Protein (E. coli) | 重组人CD40L蛋白 (E. coli) | Cytokines and Growth Factors |
| CD40 Ligand; CD154; TRAP | |||
| CD40 Ligand (CD40L/CD154/TRAP) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. The CD40 ligand stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. Recombinant Human CD40 Ligand is produced by E.coli expression system and the target gene encoding Met113-Leu261 is expressed. | |||
| M39205 | Procyanidin B2 3,3'-di-O-gallate | Procyanidin B2 3,3'-di-O-gallate | Notch |
| Procyanidin B2, 3,3'-di-O-gallate 是一种活性成分。Procyanidin B2, 3,3'-di-O-gallate 可以从葡萄籽提取物 (GSE) 原花青素混合物中分离出来。 | |||
| M40074
|
Secologanin | Secologanin | Others |
| Secologanin 是一种裂环烯醚萜苷类化合物，是生物活性单萜类吲哚类生物碱 (如利血平、Ajmaline 和长春碱) 生物合成的关键萜类中间体。Secologanin 合成酶 (细胞色素 P450 亚型 CYP72A1) 催化 loganin 氧化裂解为 Secologanin。 | |||
| M40919
|
Recombinant Human GSTM2 Protein (E. coli, His Tag) | 重组人GSTM2蛋白 (E. coli, His Tag) | Cytokines and Growth Factors |
| Glutathione S-transferase Mu 2; GST class-mu 2 | |||
| Glutathione S-transferase Mu 2, also known as GST class-mu 2, GSTM2-2, and GSTM2, is a cytoplasm protein that belongs to the GST superfamily and Mu family. A DNA sequence encoding the native human GSTM2 (Met 1-Lys 218) was expressed, with a polyhistide tag at the N-terminus. | |||
| M41616 | Batracylin | Batracylin | Topoisomerase |
| Batracylin (NSC320846) 是一种有效的 DNA 拓扑异构酶 I (DNA Topoisomerases I) 和 DNA 拓扑异构酶 II (DNA Topoisomerases I) 抑制剂。 | |||
| M49531 | Glycyl H-1152 hydrochloride | Glycyl H-1152 hydrochloride | ROCK |
| Glycyl H-1152 hydrochloride 是 Rho-kinase 抑制剂 H-1152 dihydrochloride 的糖基衍生物。 | |||
| M51387 | Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-ψ-(COO)Ala-Ser-Lys(DABCYL)-NH2 | Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-ψ-(COO)Ala-Ser-Lys(DABCYL)-NH2 | Others |
| Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-ψ-(COO)Ala-Ser-Lys(DABCYL)-NH2 (HCV NS3 protease substrate) 是一种有生物活性的肽。 | |||
