找到约 33 条 “Antagonist G” 相关结果 （用时 0.167 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M9082
|
ISO-1 | ISO-1 | NLR |
| MIF Antagonist; Macrophage Migration Inhibitory Factor | |||
| ISO-1是一种有效的巨噬细胞迁移抑制因子MIF的抑制剂，IC50值为6.2 ± 3.8 μM，可以通过降低血脑屏障(BBB)的通透性来保护神经元。此外，ISO-1还可减少NLRP3、ASC、caspase-1和IL-1β的蛋白表达，以及MIF、IL-6、TNF-α、IL-1β和IL-18的mRNA表达，可用于癌症的相关研究。 | |||
| M10242
|
Antagonist G | Antagonist G | Vasopressin Receptor |
| ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2 | |||
| Antagonist G是一个多肽，也是一种有效的vasopressin受体拮抗剂。 | |||
| M41342 | FKBP51F67V-selective antagonist Ligand2 | FKBP51F67V-selective antagonist Ligand2 | FKBP (FK506-binding protein) |
| FKBP51F67V-selective antagonist Ligand2 是一种有效的 FKBP51 F67V-选择性拮抗剂配体。 | |||
| M2584
|
MDL-29951 | MDL-29951 | GluR |
| MDL-29951 is a novel glycine antagonist of NMDA receptor activation (Ki=0.14 mM, [3H]glycine binding) in vitro and in vivo with IC50 value of 0.14 mM ([3H]glycine binding). | |||
| M2947
|
Pipenzolate Bromide | 溴哌喷酯 | AChR/AChE |
| Pipenzolate is an antimuscarinic, which binds to muscarinic receptors as an antagonist therefore preventing acetyl choline from binding to the receptors. | |||
| M9742
|
CU-CPT-9a | CU-CPT-9a | TLR |
| CU-CPT-9a is a potent TLR8 antagonist with IC50 of 0.5 nM, which that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells. | |||
| M5076
|
ZK200775 hydrate | ZK200775 hydrate | GluR |
| Fanapanel; MPQX | |||
| ZK200775 hydrate is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. | |||
| M5920
|
Ramosetron HCl | 盐酸雷莫司琼 | 5-HT Receptor |
| YM060 | |||
| Ramosetron Hydrochloride (盐酸雷莫司琼; YM060 Hydrochloride) is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting. | |||
| M6471
|
Astemizole | 阿司咪唑 | Histamine Receptor |
| Astemizole is a orally active, potent H 1 antagonist. Also K V11.1 (hERG) channel blocker. | |||
| M6639 | Cyanopindolol hemifumarate | Cyanopindolol hemifumarate | Others |
| Cyanopindolol hemifumarate is a 5-HT1A/1B antagonist with roughly equal affinity at each receptor; also a β-adrenoceptor antagonist. | |||
| M6774 | GSK 789472 hydrochloride | GSK 789472 hydrochloride | Others |
| GSK 789472 hydrochloride is a d 3 antagonist. Also D 2 partial agonist. | |||
| M6818 | Ifenprodil hemitartrate | 艾芬地尔 | Others |
| Ifenprodil hemitartrate is a non-competitive NMDA antagonist. Also σ ligand. | |||
| M6950 | Mesulergine hydrochloride | Mesulergine hydrochloride | Others |
| Mesulergine hydrochloride is a 5-HT 2A and 5-HT 2C antagonist. Also dopamine receptor partial agonist. | |||
| M7050 | NS 3763 | NS 3763 | Others |
| NS 3763 is a selective non-competitive kainate antagonist; selective for GLU K5. | |||
| M7142 | PIT 1 | PIT 1 | Others |
| PIT 1 is a pIP 3 antagonist. Blocks PIP 3-PH interaction; inhibits Akt signaling. | |||
| M7147 | PMPA (NMDA antagonist) | PMPA (NMDA antagonist) | Others |
| PMPA (NMDA antagonist) is a competitive NMDA antagonist. | |||
| M7168 | PSB 10 hydrochloride | PSB 10 hydrochloride | Others |
| PSB 10 hydrochloride is a potent, highly selective hA 3 receptor antagonist/inverse agonist. | |||
| M7259
|
SB 228357 | SB 228357 | 5-HT Receptor |
| SB 228357 is a 5-HT 2C/2B antagonist/inverse agonist. | |||
| M7283 | SDM25N hydrochloride | SDM25N hydrochloride | Others |
| SDM25N hydrochloride is a potent, selective non-peptide δ antagonist; also inhibits dengue virus replication. | |||
| M7294
|
SIB 1893 | SIB 1893 | GluR |
| SIB 1893 is a mGlu 5 antagonist and positive allosteric modulator at mGlu 4. | |||
| M7320 | Spiperone hydrochloride | 螺哌隆盐酸盐 | Others |
| Spiperone hydrochloride is a 5-HT 2A antagonist. Also D 2-like antagonist. | |||
| M7411 | threo Ifenprodil hemitartrate | threo Ifenprodil hemitartrate | Others |
| threo Ifenprodil hemitartrate is a nR2B-selective NMDA antagonist; also σ agonist. | |||
| M7445 | UBP 282 | UBP 282 | Others |
| UBP 282 is a aMPA/kainate antagonist; distinguishes between motoneuron and dorsal root kainate receptors. | |||
| M7608 | AH23848 hemicalcium salt | AH23848 hemicalcium salt | Others |
| EP4 prostanoid receptor antagonist with TP blocking activity. | |||
| M7680 | PK 11195 | PK 11195 | Parasite |
| RP 52028 | |||
| PK 11195 is a peripheral benzodiazepine antagonist. PK 11195 (RP 52028) is a ligand of translocator protein (TSPO), with IC50 values of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively. | |||
| M7695 | CGS-9343B | CGS-9343B | Others |
| CGS-9343B is a selective calmodulin antagonist with minimal protein kinase C or antidopaminergic activity. | |||
| M7697 | Chlorprothixene hydrochloride | 盐酸氯普噻吨 | Others |
| D2 dopamine receptor antagonist; blocks a subset of GABAA receptors in rat cortex that is also blocked by clozapine; thioxanthine antipsychotic. | |||
| M7783 | Efaroxan hydrochloride | 依法克生 | Others |
| (+)-Isomer is a selective α-adrenoceptor antagonist; (−)-isomer is an imidazoline ligand that induces insulin secretion, mediated by the blockade of ATP-sensitive potassium channels in pancreatic β cells; I1 imidazoline binding site antagonist. | |||
| M7859 | Idazoxan hydrochloride | 盐酸咪唑克生 | Others |
| α2-adrenoceptor antagonist; I2 imidazoline receptor agonist; I1 imidazoline receptor antagonist. | |||
| M7888 | Levocabastine hydrochloride | 左旋多巴 | Others |
| Non-peptide histamine H1 receptor antagonist; neurotensin NTS2 receptor ligand. | |||
| M7903 | Metaphit methanesulfonate salt | 蛋氨酸甲烷盐 | Sigma Receptor |
| Metaphit methanesulfonate salt is an irreversible, non-competitive antagonist at the phencyclidine site on the NMDA receptor; sigma receptor irreversible, competitive antagonist. | |||
| M7920 | MMPIP | MMPIP | Others |
| MMPIP is a potent, selective, allosteric antagonist of metabotropic glutamate receptor 7 (mGluR7). | |||
| M7932 | MRS 2395 | MRS 2395 | Others |
| Antagonist for P2Y12 purinoceptor; inhibits ADP-induced aggregation in rat platelets and antagonizes ADP-induced inhibition of cAMP in rat and human platelets in the presence of PGE1. | |||
