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Recombinant Human Siglec-7 Protein (Mammalian, C-6His) 重组人Siglec-7蛋白 (Mammalian, C-6His)

目录号 M40855 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


Human Siglec-7 encodes a 467 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. It binds equally well to both alpha 2,3- and alpha 2,6-linked sialic acid.

Recombinant Human Siglec-7 Protein (Mammalian, C-6His)结构式

别名:sialic acid binding Ig-like lectin 7; CD328 antigen; p75/AIRM1; QA79

规格 价格 库存状态
10ug ¥ 2790 中国库存现货
50ug ¥ 7920 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >95%, Endotoxin < 1 EU/μg
  • COA
  • MSDS
生物活性

Human Siglec-7 encodes a 467 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. It binds equally well to both alpha 2,3- and alpha 2,6-linked sialic acid. Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains.

Recombinant Human Sialic Acid-binding Ig-like Lectin 7 expressed the target gene encoding Gln19-Leu353 with a 6His tag at the C-terminus.


Accession: Q9Y286

Endotoxin < 1 EU/µg

Apparent Molecular Weight: 50-70 KDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

化学性质
性状 Lyophilized powder
溶解性(25°C) Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
储存条件 Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Mohammed Tarique Anwar et al. Bioorg Med Chem. Combining CuAAC reaction enables sialylated Bi- and triantennary pseudo mannose N-glycans for investigating Siglec-7 interactions

[2] Atsushi Yoshimura et al. J Biol Chem. Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells

[3] Friederike Gieseke et al. Eur J Immunol. Siglec-7 tetramers characterize B-cell subpopulations and leukemic blasts

[4] Yuzuru Ikehara et al. J Biol Chem. Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9

[5] T Angata et al. Glycobiology. Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily

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