M66013
|
Recombinant Human DLL4 Protein (HEK293, C-Fc) |
Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. DLL4 is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch 1 and Notch 4. Interactions of Notch receptors with their ligands result in reciprocal regulated intramembrane proteolysis. |
| M59150
|
Recombinant Human ER alpha (E. coli, N-6His) |
Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. |
| M59114
|
Recombinant Human CXCR4 (HEK293, N-Fc) |
CXCR4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. CXCR4 plays a role in both physiological and pathological conditions and it represents a crucial target in drug development. |
| M40857
|
Recombinant Human SIGLEC-7 Protein (HEK293, His Tag) |
Recombinant Human Sialic Acid-binding Ig-like Lectin 7 expressed the target gene encoding the Human SIGLEC7 (Q9Y286-1) (Met1-Leu353) was expressed with a polyhistidine tag at the C-terminus. The recombinant Human SIGLEC7 consists of 346 amino acids and predicts a molecular mass of 38.4 kDa. |
| M40855
|
Recombinant Human Siglec-7 Protein (HEK293, C-6His) |
Human Siglec-7 encodes a 467 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. It binds equally well to both alpha 2,3- and alpha 2,6-linked sialic acid. |
| M40853
|
Recombinant Human SIGLEC-10 Protein (HEK293, mFc Tag) |
The recombinant human SIGLEC-10 comprises 763 amino acids and has a calculated molecular mass of 84.60 kDa. A DNA sequence encoding the human SIGLEC-10 (Met17-Thr546) was expressed with the Fc region of mouse IgG2a at the C-terminus. |
| M40852
|
Recombinant Human SIGLEC-10 Protein (HEK293, His Tag) |
The recombinant human SIGLEC-10 consists of 540 amino acids and predicts a molecular mass of 59.5 kDa. A DNA sequence encoding the human SIGLEC-10 (Met17-Asn550) was expressed with a polyhistidine tag at the C-terminus. |
| M40845
|
Recombinant Human Siglec-6 Protein (HEK293, C-Fc) |
Siglec-6, also known as CD327, mediates sialic-acid dependent binding to cells. Siglec-6 binds to alpha-2,6-linked sialic acid. |
| M40843
|
Recombinant Human Siglec-9 Protein (HEK293, C-Fc) |
Sialic acid-binding Ig-like lectin 9(Siglec 9) is expressed by peripheral blood leukocytes, and found in liver, fetal liver, bone marrow, placenta, spleen and so on. It is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It also binds to alpha-2,3- or alpha-2,6-linked sialic acid. |
| M40842
|
Recombinant Human Siglec-15 Protein (HEK293, C-mFc) |
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglec-15 is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts. |
| M40841
|
Recombinant Human Siglec-15 Protein (HEK293, C-Fc) |
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglec-15 is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts. |
| M40844
|
Recombinant Human Siglec-10 Protein (HEK293, C-Fc) |
Siglec-10 binds sialated proteins and lipids in alpha 2,3 or alpha 2,6 linkage and shows a preference for GT1b gangliosides. This binding can be modulated by cis interactions of Siglec-10 with sialated molecules expressed on the same cell. |
