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Recombinant Human Siglec-6 Protein (Mammalian, C-Fc) 重组人Siglec-6蛋白 (Mammalian, C-Fc)

目录号 M40845 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


Siglec-6, also known as CD327, mediates sialic-acid dependent binding to cells. Siglec-6 binds to alpha-2,6-linked sialic acid.

Recombinant Human Siglec-6 Protein (Mammalian, C-Fc)结构式

别名:Sialic acid-binding Ig-like lectin 6; CD327; CD33 antigen-like 1

规格 价格 库存状态
10ug ¥ 1100 中国库存现货
50ug ¥ 2350 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
生物活性

Siglec-6, also known as CD327, mediates sialic-acid dependent binding to cells. Siglec-6 binds to alpha-2,6-linked sialic acid. Siglec-6 may show increasing expression human labor and following childbirth, it has been speculated that this expression helps to slow the tempo of human labor. Siglec-6 is found on B cells and in placenta, and would seem to have a restricted specificity for the sialyl Tn antigen.

Recombinant Human Sialic acid-binding Ig-like lectin 6 expressed the target gene encoding Glu27-Val331 with a human IgG1 Fc tag at the C-terminus.


Accession: O43699-3

Endotoxin < 1 EU/µg

Apparent Molecular Weight: 70-90 KDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.5.

化学性质
性状 Lyophilized powder
溶解性(25°C) Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
储存条件 Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Matthew G Cyr et al. J Immunother Cancer. Patient-derived Siglec-6-targeting antibodies engineered for T-cell recruitment have potential therapeutic utility in chronic lymphocytic leukemia

[2] Sonali R Bhagwat et al. Int J Biol Macromol. Identification of unexplored substrates of the serine protease, thrombin, using N-terminomics strategy

[3] Kristen K Rumer et al. Reprod Sci. Siglec-6 expression is increased in placentas from pregnancies complicated by preterm preeclampsia

[4] H Floyd et al. J Biol Chem. Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily

[5] N Patel et al. J Biol Chem. OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily

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