Mitoxantrone 米托蒽醌

目录号 M3493 所有产品仅供科研使用，严禁用于人或动物的治疗等任何其他用途，不为任何个人提供产品和服务

Mitoxantrone是一种II型拓扑异构酶（Topoisomerase）抑制剂，作用于HepG2和MCF-7/wt细胞，IC50为2.0 μM和0.42 mM。

别名：Mitozantrone

规格	价格	库存状态
10mg	¥ 360	中国库存现货
50mg	¥ 495	中国库存现货
100mg	¥ 720	中国库存现货

其他规格数量报价？

质量标准及产品资料

纯度： >98%
COA
MSDS
H-NMR

产品信息

生物活性

Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 µM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively. It is an anthracenedione (not an anthracycline) antineoplastic agent. It disrupts DNA synthesis and DNA repair in both healthy cells and cancer cells. It is used in the treatment of certain types of cancer, mostly metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin’s lymphoma. It was also shown to improve the survival of children suffering from first relapse of acute lymphoblastic leukaemia. It also engages in intercalation.

使用AbMole产品发表的文献

J Korean Med Sci. 2016 Jun;31(6): 836–842.

Silencing of ABCG2 by MicroRNA-3163 Inhibits Multidrug Resistance in Retinoblastoma Cancer Stem Cells

产品使用成果展示

	数据来源	J Korean Med Sci (2016). Figure 5. cisplatin, mitoxantrone and topotecan were all purchased from AbMole BioScience Inc. (Houston, USA).
	方法	CCK8 Assay and ABCG2 ATPase assay
	细胞系/动物模型	RCSC cells
	浓度	0~10 μM
	处理时间	72 h
	实验结果	MiR-3163 plays important roles in multidrug resistance (Table 1, Fig. 5A). Results showed that when miR-3163 was overexpressed in RCSCs, the ATPase activity of ABCG2 was significantly downregulated compared to RCSCs with Scramble (Fig. 5B).

	数据来源	J Korean Med Sci (2016). Figure 4. cisplatin, mitoxantrone and topotecan were all purchased from AbMole BioScience Inc. (Houston, USA).
	方法	CCK8 Assay and flow cytometry analysis
	细胞系/动物模型	RCSC cells
	浓度	0~10 μM
	处理时间	72 h
	实验结果	A lower proliferation rate was observed in RCSCs transfected with miR-3163 Mimics using the CCK-8 assay (Fig. 4A).RCSCs treated with miR-3163 Mimics were more susceptible to cisplatin-induced apoptosis compared to those treated with Scramble (Fig.4B).

化学性质

分子量	444.48
分子式	C22H28N4O6
CAS号	65271-80-9
溶解性（25°C）	DMSO 80 mg/mL
储存条件	-20°C, protect from light
运输方式	冰袋运输，根据产品的不同，可能会有相应调整。

储备液配制

*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前，需考虑其在不同溶剂中的溶解度限制。

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.2498 mL	11.2491 mL	22.4982 mL
5 mM	0.45 mL	2.2498 mL	4.4996 mL
10 mM	0.225 mL	1.1249 mL	2.2498 mL

不同实验动物依据体表面积的等效剂量转换表（参考来源于公开文献）

	小鼠	大鼠	兔	豚鼠	仓鼠	狗
重量 (kg)	0.02	0.15	1.8	0.4	0.08	10
体表面积 (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m 系数	3	6	12	8	5	20

动物 A (mg/kg) = 动物 B (mg/kg) ×	动物 B的K_m系数
	动物 A的K_m系数

例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的K_m系数（3），再除以大鼠的K_m系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。

参考文献

[1] Abraham Chang. A case of mitoxantrone extravasation

[2] Mirela Enache, et al. Mitoxantrone-Surfactant Interactions: A Physicochemical Overview

[3] Benny J Evison, et al. Mitoxantrone, More than Just Another Topoisomerase II Poison

[4] F Martinelli Boneschi, et al. Mitoxantrone for multiple sclerosis

[5] I Pericot, et al. Mitoxantrone

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