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Recombinant Human IFN-β (HEK 293) 重组人IFN-β蛋白(HEK 293)

目录号 M13441 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


重组人IFN-β蛋白(HEK 293)通过STAT1和STAT2发挥作用,已知可上调和下调多种基因,其中大多数参与抗病毒免疫应答。蛋白构造:IFN-β (Met22-Asn187) ,Accession # P01574。

Recombinant Human IFN-β (HEK 293)结构式
规格 价格 库存状态
5ug ¥ 1188 中国库存现货
25ug ¥ 3375 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >95% , Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
生物活性

表达系统:HEK 293
纯度:SDS-PAGE分析,> 95%
内毒素:凝胶凝血法测定蛋白质< 0.2 EU/μg
表观分子量:~23 kDa,还原条件下在SDS-PAGE上
存储及稳定性:在接收后,该产品在低于-70°C的环境下保持稳定长达6个月。重组后,产品应在4°C下稳定1周或在-20°C下稳定3个月。为了长期保存,建议添加载体蛋白(如0.1% BSA)。避免反复的冻融循环。

生物活性:干扰素β (IFN-β)通过STAT1和STAT2发挥作用,已知可上调和下调多种基因,其中大多数参与抗病毒免疫应答。它是I型干扰素的成员,I型干扰素包括IFN-α、-β、τ和-ω。IFN-β在诱导对广泛的病毒感染的非特异性耐药性中发挥重要作用。它还影响细胞增殖和调节免疫反应。

化学性质
储存条件 粉末型式       -20°C   3年;4°C   2年
溶于溶剂       -80°C   6个月;-20°C   1个月
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Zhang Xiangbo, et al. Arch Microbiol. Bovine coronavirus nucleocapsid suppresses IFN-β production by inhibiting RIG-I-like receptors pathway in host cells

[2] Samira Khiar, et al. Sci Rep. Identification of a small molecule that primes the type I interferon response to cytosolic DNA

[3] Kay-Sara Sauter, et al. Vet Immunol Immunopathol. Stable transduction of bovine TLR4 and bovine MD-2 into LPS-nonresponsive cells and soluble CD14 promote the ability to respond to LPS

[4] Meenakshi Upreti, et al. Biochem Biophys Res Commun. Replacement of 198MQMDII203 of mouse IRF-1 by 197IPVEVV202 of human IRF-1 abrogates induction of IFN-beta, iNOS, and COX-2 gene expression by IRF-1

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