找到约 45 条 “SA-VA” 相关结果 （用时 0.297 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M5731
|
LCZ696 | 沙库必曲/缬沙坦 | Angiotensin Receptor |
| Sacubitril/Valsartan；Entresto | |||
| LCZ696由Valsartan和Sacubitril以1：1的摩尔比组成，是一种首创(first-in-class)的双效血管紧张素受体-脑啡肽酶抑制剂（ARNi,angiotensin receptor-neprilysin inhibitor），用于研究高血压和心脏衰竭。 | |||
| M9962
|
Nonivamide | 壬酸香草酰胺 | TRP Channel |
| Capsaicin; Pelargonic acid vanillylamide; PAVA | |||
| Nonivamide（壬酸香草酰胺）是Capsaicin的类似物，是TRPV1(Vanilloid receptor subtype 1)的激动剂。可以激活TRPV1受体，从而刺激大脑腹侧被盖区的多巴胺能神经元的放电速率，并增加5-羟色胺受体基因HTR2A的表达。 | |||
M14988
|
Chikusetsusaponin Iva | 竹节人参皂苷 IVA | Others |
| Calenduloside F | |||
| 竹节参皂苷ⅣA (Chikusetsusaponin IVa) 是三萜皂苷中主要的活性成，是蛋白激酶的激活剂，对血栓及一些代谢性疾病具有抵抗作用。 | |||
| M16732 | Isosativanone | Isosativanone | Flavonoids |
| Isosativanone | |||
| M16784 | Isosativan | Isosativan | Flavonoids |
| Isosativan | |||
| M20451
|
Granisetron | Granisetron | 5-HT Receptor |
| Sancuso, Kevatril, Granisetronum, Sustol | |||
| Granisetron is a serotonin receptor (5HT-3 selective) antagonist that is used as an antiemetic and antinauseant for cancer chemotherapy. | |||
| M20720 | Vindesine sulfate | Vindesine sulfate | Microtubule |
| Eldesine, Eldisine, Desacetyl Vinblastine amide, Desacetylvinblastine amide, DAVA, DVA, VDS | |||
| Vindesine sulfate (Eldesine, Eldisine, Desacetyl Vinblastine amide, Desacetylvinblastine amide, DAVA, DVA, VDS), a vinca alkaloid derived from Catharanthus roseus, is a potent inhibitor of mitosis with antineoplastic activities. Vindesine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. | |||
| M21178
|
TAK-653 | TAK-653 | GluR |
| Osavampator | |||
| Osavampator (TAK-653) 是一款潜在的同类首创（first-in-class）的α氨基-3-羟基-5-甲基-4-异恶唑丙酸(AMPA)增强剂。 | |||
| M25409 | Satavaptan | 沙他普坦；萨塔瓦坦；萨托伐普坦 | Vasopressin Receptor |
| SR121463 | |||
| Satavaptan（SR 121463）是一种血管加压素V2受体（Vasopressin V2 receptor (V2R)）的拮抗剂。Satavaptan能用于对肝硬化腹水的研究。 | |||
| M25424
|
Recombinant Human Fibronectin (Oryza sativa) | 重组人纤连蛋白 (Oryza sativa) | Cytokines and Growth Factors |
| rhFN | |||
| Recombinant Human Fibronectin 重组人纤维连接蛋白是一种细胞外糖蛋白，作为主要的细胞粘附分子之一，纤连蛋白FN在许多重要的生理过程中起着关键性作用，如胚胎生成，伤口愈合，止血和血栓形成。纤连蛋白可以促进细胞生长，提高细胞贴壁率，增强细胞代谢水平，缩短细胞生长时间。 | |||
| M25438
|
Recombinant Human Transferrin (Oryza sativa) | 重组人转铁蛋白 (Oryza sativa) | Cytokines and Growth Factors |
| 转铁蛋白是一种存在于血清中的主要铁结合和细胞传递分子。 无血清细胞培养系统需要一种铁的传递形式。 转铁蛋白是铁的优选传递形式，因为细胞可通过细胞表面上的转铁蛋白受体以生理学上适当的方式对转铁蛋白结合的铁进行处理。 | |||
| M28943 | Sangivamycin | Sangivamycin | PKC |
| NSC 65346; BA-90912 | |||
| Sangivamycin (NSC 65346) 是一种核苷类似物，是蛋白激酶C (PKC) 的有效抑制剂，Ki 为 10 μM。Sangivamycin 对多种人类癌症具有有效的抗增殖活性。 | |||
| M29474 | Azilsartan mopivabil | Azilsartan mopivabil | Angiotensin Receptor |
| Azilsartan mopivabil 是血管紧张素 II 受体 (angiotensin II receptor) 的强效拮抗剂。 | |||
| M40501 | Salivaricin B | Salivaricin B | Antibiotic |
| Salivaricin B是一种由唾液链球菌产生的化合物，并对唾液链球菌、化脓链球菌、轻型链球菌、藤黄微球菌等常见人体微生物具有抑制活性。 | |||
| M43452 | SA-VA | SA-VA | PROTAC |
| SA-VA 是一种基于叠氮化物和炔烃的细胞内自组装 PROTAC。 | |||
| M44441 | Sativanone | Sativanone | Others |
| Sativanone | |||
| M52870 | Desamino(D-3-(3′-pyridyl)-Ala2, Arg8)-Vasopressin | Desamino(D-3-(3′-pyridyl)-Ala2, Arg8)-Vasopressin | Vasopressin Receptor |
| Desamino(D-3-(3′-pyridyl)-Ala2,Arg8)-Vasopressin 是一种合成的抗利尿激素 (AVP) 的类似物，是抗利尿受体的弱激动剂。 | |||
| M53219 | Sauvagine | Sauvagine | CRFR |
| Sauvagine，是一种来自青蛙皮肤的 40 个氨基酸的神经肽，是哺乳动物 CRF 激动剂。 | |||
| M56168 | Antisauvagine-30 | Antisauvagine-30 | CRFR |
| Antisauvagine-30 (aSvg-30) 是一种有效的、竞争性的、选择性的 CRF2 receptor 拮抗剂，针对小鼠 CRF2 细胞和大鼠 CRF1 受体的 Kd 值分别为 1.4 nM 和 153.6 nM。 | |||
| M56000 | Lisavanbulin | Lisavanbulin | Microtubule |
| Lisavanbulin (BAL-101553) 是微管蛋白靶向剂 Avanbulin (BAL 27862) 的前药。Lisavanbulin 具有抗肿瘤活性，尤其是在高水平表达末端结合蛋白 1 的肿瘤中。 | |||
| M55998 | Lisavanbulin dihydrochloride | Lisavanbulin dihydrochloride | Microtubule |
| Lisavanbulin (BAL-101553) dihydrochloride 是微管蛋白靶向剂 Avanbulin (BAL 27862) 的前体。Lisavanbulin dihydrochloride 具有抗肿瘤活性，尤其是在高水平表达末端结合蛋白 1 的肿瘤中。 | |||
| M1999
|
Vadimezan (DMXAA) | 伐地美生 | STING |
| ASA404; DMXAA | |||
| Vadimezan (DMXAA，ASA-404，伐地美生) 是一种鼠干扰素基因 (STING) 激动剂和 I 型 IFN 及其他细胞因子的强效诱导剂。此外，Vadimezan 还具有抗流感病毒 H1N1-PR8 的活性。 | |||
| M2475
|
Bucladesine Sodium Salt | 布拉地新钠盐；二丁酰环磷腺甙； | PKA |
| Dibutyryl-cAMP sodium salt; DC2797; Sodium dibutyryl cAMP | |||
| Bucladesine Sodium Salt是一种，膜渗透性的选择性PKA激动剂，在PC12细胞中，通过Ca2+-和PKA-依赖的方式激活细胞外信号调节激酶(ERK)，显著上调ChAT和VAChT基因表达。 | |||
| M4446
|
Cimifugin | 升麻素 | Others |
| Cimitin | |||
| Cimifugin (Cimitin，升麻素)是Saposhnikovia divaricate 的生物活性成分。Cimifugin 通过调节紧密连接减少上皮衍生的主动关键因子，从而抑制过敏性炎症。 | |||
| M7243 | SAG 21k | SAG 21k | Others |
| SAG 21k is a hedgehog signaling activator; brain penetrant and orally bioavailable. | |||
| M7698
|
Capsazepine | 辣椒平 | TRP Channel |
| Capsazepine（辣椒平）是一种Capsaicin的合成类似物，是TRPV1（Vanilloid type 1）的拮抗剂，在体外具有抗癌，调节炎症等功能。 | |||
| M8476 | Cuspin-1 | Cuspin-1 | Others |
| Cuspin-1 (Chemical Upregulator of SMN Protein-1) is an upregulator of the Survival of Motor Neuron protein (SMN), necessary for survival of motor neurons. | |||
| M8772 | SAK3 | SAK3 | Others |
| SAK3 is a potent and orally active spiroimidazopyridine derivative that enhances Cav3. | |||
| M8796 | TCPOBOP | TCPOBOP | Others |
| TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct agonist of CAR. | |||
| M13472
|
Murepavadin TFA | 莫瑞伐定TFA盐 | Antibiotic |
| POL7080 TFA | |||
| Murepavadin TFA (POL7080 TFA) 是一种14氨基酸环肽，是一种强效、特异性的抗生素，可用于 Pseudomonas aeruginosa 引起的细菌感染的研究。Murepavadin TFA 靶向作用于脂多糖转运蛋白 portin D。 | |||
| M14390
|
Mevalonic acid lithium salt | Mevalonic acid lithium salt | Metabolite/Endogenous Metabolite |
| Mevalonic acid lithium salt 是甲羟戊酸途径 (mevalonate pathway) 的前体，对细胞生长和增殖至关重要。 | |||
| M15075
|
Ensulizole | 苯基苯并咪唑磺酸； 恩索利唑 | ROS |
| PBSA | |||
| Ensulizole (PBSA) 是一种水溶性防晒成分，一种磺化的UV吸收剂，其特征是可强烈吸收UVB和部分吸收UVA。Ensulizole 可以在紫外线或阳光照射下通过产生活性氧 (ROS) 来破坏 DNA。 | |||
| M16158
|
Koenimbine | Koenimbine | Alkaloids |
| NSC 127152; Koenimbin; Kenimbine | |||
| Koenimbine is a natural product isolated from Murraya koenigii. The IC50 values of koenimbine in HT-29 and SW48 was calculated to be 50 μg/ml based on the MTT assay. The IC50 value was 75 μg/ml in IEC-18 cells. | |||
| M18010 | 5-hydroxy-3',4',6,7-tetramethoxyflavone | 5-羟基-3',4',6,7-四甲氧基黄酮 | Antibiotic |
| 5-desmethylsinensetin 可从 Stevia satureiifolia var. satureiifolia 中分离得到，具有抗原生动物的活性。 | |||
| M18163 | Isovitexin 2''-O-arabinoside | 异牡荆素-2''-O-阿拉伯糖苷 | Others |
| Isovitexin 2''-O-arabinoside 是 Avena sativa L. 幼苗中的一种非活性类黄酮。 | |||
| M20400 | Morin Hydrate | Morin Hydrate | Others |
| Aurantica | |||
| Morin hydrate(Aurantica) is a flavonoid isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and from leaves of Psidium guajava (common guava). | |||
| M20453 | Mupirocin calcium | Mupirocin calcium | Antibiotic |
| pseudomonic acid A | |||
| Mupirocin Calcium is the calcium salt form of mupirocin, a natural crotonic acid derivative extracted from Pseudomonas fluorescens,which inhibits bacterial protein synthesis and is used as an antibiotic. | |||
| M20467 | Paroxetine mesylate | Paroxetine mesylate | 5-HT Receptor |
| Paroxetine Mesylate is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. | |||
| M20475
|
Safinamide | Safinamide | Others |
| EMD-1195686, PNU-15774E | |||
| Safinamide is an orally active, selective, reversible |
|||
| M20606 | SAR125844 | SAR125844 | c-Met |
| SAR125844 is a potent intravenously active and highly selective MET kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively). | |||
| M20614 | NSC-87877 disodium salt | NSC-87877 disodium salt | Phosphatase |
| NSC-87877 disodium is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. NSC-87877 disodium salt also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation. | |||
| M20914 | Isosorbide dinitrate | Isosorbide dinitrate | Others |
| Sorbide nitrate, Sorbidnitrate, Isordil, Nitrosorbide | |||
| Isosorbide Dinitrate is the dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. It is used in the treatment of angina pectoris. | |||
| M20927 | Betahistine mesylate | Betahistine mesylate | Histamine Receptor |
| Betahistine mesylate is the mesylate salt form of Betahistine, a histamine analog and H3 receptor agonist that serves as a vasodilator. | |||
| M20937 | Midodrine hydrochloride | Midodrine hydrochloride | Adrenergic Receptor |
| Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor. | |||
| M20942 | Choline Fenofibrate | Choline Fenofibrate | PPAR |
| Choline fenofibrate is a newly developed choline salt of fenofibric acid, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity that acts as an PPARα agonist. | |||
