找到约 34 条 “PTIO” 相关结果 （用时 0.09 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M5624
|
Eslicarbazepine Acetate | 醋酸艾司利卡西平 | BACE |
| BIA 2093, Zebinix, Exalief, Stedesa, Aptiom | |||
| Eslicarbazepine acetate是一种抗癫痫药物。 | |||
| M6561
|
Carboxy-PTIO, potassium salt | 一氧化氮清除剂 | NO Synthase |
| Carboxy-PTIO potassium 是一种有效的一氧化氮 (NO) 清除剂，能与 NO 快速反应产生 NO2。 | |||
| M40802
|
PTIO | PTIO | Others |
| PTIO是一种 NO 清除剂，*NO的监测器，*NO2的化学计量源，以及生化和生理效应物，PTIO 能与 NO 反应生成相应的亚氨基氮氧化物和 *NO2。 | |||
| M43836
|
Recombinant Human AP2 Gamma/TFAP2C Protein (E. coli, His Tag) | 重组人AP2 Gamma/TFAP2C 蛋白 (E. coli, His Tag) | Cytokines and Growth Factors |
| hAP-2g Protein; transcription factor AP-2 gamma | |||
| TFAP2C, also known as AP2-GAMMA, is a member of the activating protein 2 family of transcription factors. TFAP2C may be prognostic indicators for breast tumors. | |||
| M51429 | Transcriptional Intermediary Factor 2 (TIF2) (740-753) | Transcriptional Intermediary Factor 2 (TIF2) (740-753) | Others |
| Transcriptional Intermediary Factor 2 (TIF2) (740-753) 是转录中介因子 2 (TIF2) 的共激活肽，由 TIF-2 蛋白的 14 个氨基酸残基 (740KENALLRYLLDKDD753) 组成。 | |||
| M25395
|
GSK1379725A | GSK1379725A | Epigenetic Reader Domain |
| AU1; AU-1 | |||
| GSK1379725A（AU1）是首个选择性的BPTF（Bromodomain PHD Finger Transcription Factor）配体，Kd值为2.8uM，对Brd4无结合活性。 | |||
| M7009 | Muristerone A | 米乐甾酮A | Others |
| Muristerone A is a stimulates Bcl-XL mRNA transcription; antiapoptotic. | |||
| M7965 | Neridronate | 奈立膦酸 | Others |
| Neridronate is a bone resorption inhibitor. | |||
| M7972 | NSC308848 | NSC308848 | Others |
| NSC308848 is a small molecular transcription factor inhibitor. | |||
| M7980
|
Ouabain octahydrate | 毒毛旋花苷G；乌本(箭毒)苷；哇巴因 | Others |
| Acocantherine; G-Strophanthin | |||
| Cardiac glycoside, inhibits Na(+)/K(+) ATPase, regulates transcription of MDR (increase, Pgp) and MRP (increase MRP1 and decrease CFTR, cyctic fibrosis transport receptor or cAMP-activated Cl- channel) genes, also alters localization of MRP1. | |||
| M8263 | LY255582 | LY255582 | Others |
| LY255582 inhibits the diet-associated increases in mesolimbic dopamine levels and reduces the consumption of highly-palatable food intake. | |||
| M8334 | FQI1 | FQI1 | Others |
| FQI1 inhibits the DNA-binding activity of LSF, a ubiquitous transcription factor that is up regulated in many hepatocellular carcinomas (HCC). | |||
| M8452
|
ELN484228 | ELN484228 | Others |
| ELN-484228 | |||
| ELN484228 is a cell penetrant α-synuclein ligand that rescues of α-synuclein induced disruption of vesicle trafficking and dopaminergic neuronal loss and neurite retraction. | |||
| M8525 | CCT031374 hydrobromide | CCT031374 hydrobromide | Others |
| CCT031374 is an inhibitor of TCF-dependent transcription. | |||
| M8595 | DC_AC50 | DC_AC50 | Others |
| DC_AC50 is an inhibitor of copper trafficking proteins Atox1 and CCS, resulting in a disruption of cellular copper transport. | |||
| M8655 | SI-2 | SI-2 | Others |
| SI-2 targets the receptor-interacting domain (RID) of steroid receptor coactivators (SRCs) and suppresses cellular transcriptional activity (Effec. | |||
| M8693 | DSHN | DSHN | Others |
| DSHN is a potent and selective activator of SHP (small heterodimer partner, NR0B2) that transcriptionally activates SHP mRNA and stabilized the SHP protein by preventing its ubiquitination and degradation. | |||
| M8860
|
X80 | X80 | DNA/RNA Synthesis |
| X80 is an inhibitor of xeroderma pigmentosum group A protein (XPA protein) required for the removal of all types of DNA lesions repaired by nucleotide excision repair Including both transcription coupled and global genomic nucleotide excision repair. | |||
| M9302
|
CBL0137 | CBL0137 | p53 |
| Curaxin 137; CBL-C137 | |||
| CBL0137是一种组蛋白伴侣蛋白FACT（Facilitates Chromatin Transcription）的抑制剂。CBL0137通过抑制FACT的功能，干扰染色质的动态平衡，从而影响DNA复制、转录和损伤修复过程。此外，它还具有激活p53通路、抑制NF-κB信号通路以及诱导免疫原性细胞死亡等多种活性。 | |||
| M15095
|
Recombinant Mouse RANKL (HEK293, N-6His) | 重组小鼠RANKL蛋白 (HEK293, N-6His) | Cytokines and Growth Factors |
| Tnfsf11 | |||
| Recombinant Mouse RANKL/TNFSF11 is a member of the tumor necrosis factor (TNF) cytokine family. Tnfsf11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune response and enhancing bone-resorption in humoral hypercalcemia of malignancy. It augments the ability of dendritic cells to stimulate naive T-cell proliferation. | |||
| M20096 | WAY-321873 | WAY-321873 | Others |
| WAY-321873 is a modulator of GATA4-NKX2-5 transcriptional synergy | |||
| M20380 | WAY-306955 | WAY-306955 | p38 MAPK |
| WAY-306955 is a modulator of transcriptional repression. | |||
| M20567 | Salicylamide | Salicylamide | Immunology/Inflammation |
| o-hydroxybenzamide | |||
| Salicylamide is a non-prescription drug with analgesic and antipyretic properties. | |||
| M20625 | HJC0152 | HJC0152 | STAT |
| HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor with remarkably improved aqueous solubility. | |||
| M20750 | A2764 dihydrochloride | A2764 dihydrochloride | Potassium Channel |
| A2764 dihydrochloride is a selective inhibitor of TRESK (TWIK-related spinal cord K+ channel, K2P18.1) with IC50 of 11.8 μM for the activated mTRESK channel. A2764 dihydrochloride has the potential for probing the role of TRESK channel in migraine and nociception. | |||
| M20775 | SEC inhibitor KL-1 | SEC inhibitor KL-1 | Others |
| KL-1 | |||
| SEC inhibitor KL-1 (KL-1) is a potent and selective inhibitor of super elongation complex (SEC) that disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with Ki of 3.48 μM. | |||
| M20806 | EN4 | EN4 | Others |
| EN4, a covalent ligand that targets cysteine 171 (C171) of MYC, is selective for c-MYC over N-MYC and L-MYC. EN4 inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis. | |||
| M20870 | Sodium phenylpyruvate | Sodium phenylpyruvate | Others |
| Phenylpyruvic acid sodium salt | |||
| Sodium phenylpyruvate (Phenylpyruvic acid sodium salt) inhibits amino acid formation and depresses oxygen consumption. | |||
| M20885 | KKL-10 | KKL-10 | Anti-infection |
| KKL-10 is an inhibitor of ribosome rescue that exhibits exceptional broad-spectrum antimicrobial activity against bacteria. | |||
| M20990 | Norethindrone acetate | Norethindrone acetate | Estrogen Receptor |
| 19-Norethindrone acetate, NA | |||
| Norethindrone acetate (19-Norethindrone acetate, NA) is a common synthetic hormone used in oral contraceptives. Norethindrone acetate is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis. | |||
| M21009
|
L-Ornithine hydrochloride | L-Ornithine hydrochloride | Others |
| (S)-2,5-Diaminopentanoic acid | |||
| L-ornithine hydrochloride ((S)-2,5-Diaminopentanoic acid) has an antifatigue effect by increasing the efficiency of energy consumption and promoting the excretion of ammonia. It is one of the key reactants in the urea cycle. | |||
| M21013 | Clodronate disodium tetrahydrate | Clodronate disodium tetrahydrate | Others |
| Clodronate is a non-nitrogenous bisphosphonate that can bind to bone to reduce the bone resorption. It is used as an anti-osteoporotic drug for the prevention of osteoporosis in post-menopausal women and men. | |||
| M21156
|
BI-3802 | BI-3802 | Bcl-2 |
| BI-3802 是一种高效的 oncogenic transcription factor BCL6 的降解物，对目标基因有很强的抑制作用，具有抗增殖作用。BI-3802 可抑制BCL6的BTB结构域，对应的IC50值 ≤ 3 nM。BI-3802 具有抗肿瘤的活性。 | |||
| M25383
|
Recombinant Human KEAP1 Protein (Baculovirus-Insect) | 重组人KEAP1蛋白 (Baculovirus-Insect) | Cytokines and Growth Factors |
| Kelch-like ECH-associated protein 1; INRF2 | |||
| Kelch-like ECH-associated protein 1 (KEAP1) is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB (POZ) domain, and six Kelch repeats. KEAP1 is a key regulator of the NRF2 transcription factor, which transactivates the antioxidant response element (ARE) and upregulates numerous proteins involved in antioxidant defense. | |||
