找到约 18 条 “P1” 相关结果 （用时 0.048 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
| M7096 | P1075 | P1075 | Others |
| P1075 is a potent K ir6 (K ATP) channel opener. | |||
M7126
|
PF CBP1 | PF CBP1 | Epigenetic Reader Domain |
| PF CBP1是一种高度选择性的CREB结合蛋白（CBP）溴结构域（bromodomain，Brd）抑制剂，其对CBP和BRD4的IC50值分别为0.13 µM和18.1 µM，同时还能下调神经元中与帕金森病（PD）相关的靶点RGS4的表达，可用于神经系统疾病的研究。 | |||
| M7448 | UBP1112 | UBP1112 | Others |
| UBP1112 is a group III mGlu antagonist. | |||
| M8261 | TVP1022 | TVP1022 | Monoamine Transporter |
| (S)-Rasagiline; S-PAI | |||
| TVP1022是 Rasagiline 的低活性 S-对映体形式。Rasagiline 是一种高效的不可逆的选择性线粒体单胺氧化酶 (MAO) 抑制剂，抑制大鼠脑 MAO B 和 MAO A 的 IC50 分别为 4.43 nM 和 412 nM。 | |||
| M8641 | LP117 | LP117 | Others |
| LP117 is a pirinixic acid derivative that interferes with ATP-binding cassette (ABC) transporter ABCB1-mediated substrates transport, including vincristine, vinorelbine, paclitaxel, and actinomycin D, but not doxorubicin, rhodamine 123, or JC-1. | |||
M10197
|
(Glp1)-Apelin-13 human, bovine | 人,牛(GLP1)-APELIN-13肽；[PYR1]-爱帕琳肽-13 | Apelin Receptor |
| [Pyr1]-Apelin-13 | |||
| (Glp1)-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist. | |||
| M15093
|
Recombinant Human EpCAM/Trop1 (Expi293, C-His) | 重组人EpCAM/Trop1 蛋白 (Expi293, C-His) | Cytokines and Growth Factors |
| CD326 antigen; CD326; EGP; EGP-2 | |||
| 上皮细胞粘附分子(EpCAM)，也被称为KS1/4、gp40、GA733-2、17-1A和TROP -1，是一个40 kDa的跨膜糖蛋白，由242个氨基酸(aa)的胞外结构域(有两个EGF样重复)、一个23 aa的跨膜片段和一个26 aa的细胞质结构域组成。 | |||
| M25384
|
Recombinant Human KEAP1 Protein (Baculovirus-Insect, His & GST Tag) | 重组人KEAP1蛋白 (Baculovirus-Insect, His & GST Tag) | Cytokines and Growth Factors |
| Kelch-like ECH-associated protein 1; INRF2 | |||
| Kelch-like ECH-associated protein 1 (KEAP1) is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB (POZ) domain, and six Kelch repeats. KEAP1 is a key regulator of the NRF2 transcription factor, which transactivates the antioxidant response element (ARE) and upregulates numerous proteins involved in antioxidant defense. | |||
| M25383
|
Recombinant Human KEAP1 Protein (Baculovirus-Insect) | 重组人KEAP1蛋白 (Baculovirus-Insect) | Cytokines and Growth Factors |
| Kelch-like ECH-associated protein 1; INRF2 | |||
| Kelch-like ECH-associated protein 1 (KEAP1) is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB (POZ) domain, and six Kelch repeats. KEAP1 is a key regulator of the NRF2 transcription factor, which transactivates the antioxidant response element (ARE) and upregulates numerous proteins involved in antioxidant defense. | |||
| M25440
|
Recombinant Human Osteopontin/SPP1 Protein (HEK293, C-6His) | 重组人Osteopontin/SPP1蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
| OPN; Secreted Phosphoprotein 1 | |||
| Osteopontin/SPP1 is a secreted multifunctional glycoprotein. Its putative functions include roles in bone metabolism, immune regulation, wound healing, cell survival, and tumor progression. Osteopontin/SPP1 acts as a cytokine that is involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10. | |||
| M43971
|
Recombinant Human MMP12 Protein (E. coli) | 重组人MMP12 蛋白 (E. coli) | Enzymes & Regulators |
| Matrix metalloproteinase-12 | |||
| Matrix metalloproteinase-12 (MMP12) is a macrophage-secreted elastase that is highly induced in the liver and lung in response to S. mansoni eggs and contains four hemopexin-like domains. MMP12 is a proteolytic enzyme responsible for the cleavage of plasminogen to angiotensin, which has an angiostatic effect. | |||
| M54866
|
Recombinant Human USP14 (E.coli, N-6His) | 重组人USP14 (E.coli, N-6His) | Cytokines and Growth Factors |
| Ubiquitin Carboxyl-Terminal Hydrolase 14; Deubiquitinating Enzyme 14 | |||
| USP14 belongs to the ubiquitin-specific processing (USP) family which is a deubiquitinating enzyme (DUB) with His and Cys domains. USP14 acts also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. | |||
| M55225
|
PTD-p65-P1 Peptide TFA | PTD-p65-P1 肽 TFA | NF-κB |
| PTD-p65-P1 肽 TFA 是一种强效的、选择性的核转录因子 NF-κB 抑制剂，来源于 NF-κB 的 p65 亚基氨基酸残基 271-282，可选择性地抑制各种炎症刺激诱导的 NF-κB 激活，下调 NF-κB 介导的基因表达，上调细胞凋亡。 | |||
| M55373
|
Recombinant Human THOP1 (E.coli, C-6His) | 重组人THOP1蛋白 (E.coli, C-6His) | Cytokines and Growth Factors |
| Thimet Oligopeptidase | |||
| Thimet Oligopeptidase (THOP1) is involved in the metabolism of neuropeptides under 20 amino acid residues and degradation of cytoplasmic peptide. In addition, THOP1 also can degrade the beta-amyloid precursor protein and generate amyloidogenic fragments. | |||
| M55642 | LY3540378 | LY3540378 | RXFP |
| LY-3540378 | |||
| LY3540378是一种有效的体外RXFP1激动剂，并且对RXFP2的选择性与天然人类松弛素-2相当。LY3540378在RXFP3和RXFP4受体上没有表现出任何活性。LY3540378是一种长效单体融合蛋白，由单链松弛素2类似物以B链/连接子/A链配置与血清白蛋白结合VHH结构域(albVHH)结合，以延长半衰期。对人血清白蛋白的亲和力为81pM。 | |||
| M55681
|
Recombinant Human MMP13 Protein (E. coli, N-His) | 重组人MMP13 蛋白 (E. coli, N-His) | Enzymes & Regulators |
| Matrix metalloproteinase-13; Collagenase 3 | |||
| MMP-13 蛋白在细胞外基质蛋白，尤其是纤维状胶原、纤连蛋白、TNC 和 ACAN 的降解中发挥作用。它可裂解三螺旋胶原蛋白，优先裂解 II 型胶原蛋白，还可以靶向其他胶原蛋白类型。 | |||
| M58339
|
Recombinant ACIBA PBP1a (E.Coli) | 重组ACIBA PBP1a (E.Coli) | Cytokines and Growth Factors |
| AC-PBP1a | |||
| ACIBA PBP1a（青霉素结合蛋白 1A）可参与细胞壁的形成，并在从脂质中间体合成交联肽聚糖的过程中发挥着至关重要的作用。该酶具有双功能结构，由一个对青霉素不敏感的转糖基酶 N 端结构域负责线性聚糖链的形成，另一个对青霉素敏感的转肽酶 C 端结构域促进肽亚基的交联。 | |||
| M58348
|
Recombinant Human PTP1B (E.Coli) | 重组人PTP1B (E.Coli) | Cytokines and Growth Factors |
| PTP1B蛋白，即蛋白酪氨酸磷酸酶1B，是内质网折叠蛋白反应的调节剂。PTP1B与蛋白酪氨酸激酶（PTK）共同维持着酪氨酸蛋白磷酸化的平衡，这是细胞信号转导的关键过程。 | |||
