找到约 19 条 “Lipoxygenase” 相关结果 （用时 0.421 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M4574
|
Wedelolactone | 蟛蜞菊内脂；蟛蜞菊内酯 | Caspase |
| Wedelolactone是一种来自 Ecliptae herba 的天然产物，通过直接抑制 IKK 复合物来抑制 LPS 诱导的 caspase-11 表达。且通过氧自由基清除机制抑制 5-脂氧合酶 (5-lipoxygenase, 5-Lox) (IC50~2.5 μM) 活性。Wedelolactone 通过下调 PKCε 诱导前列腺癌细胞中 caspase 依赖性细胞凋亡 (apoptosis) 而不抑制 Akt。具有抗癌，抗炎和抗氧化活性。 | |||
| M7983 | 9,12-Octadecadiynoic acid | 9,12-Octadecadiynoic acid | Others |
| Potent cyclooxygenase and lipoxygenase inhibitor. | |||
| M8251 | CJ-13610 | CJ-13610 | Others |
| CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC50 = 70 nM). | |||
| M8370 | NCTT-956 | NCTT-956 | Others |
| NCTT-956 is a very potent, specific inhibitor of 12-lipoxygenase (12-LO) activity, with an IC50 of 800 nM, no activity against 5-LO and greater than 25-fold selectivity over 15-LO. | |||
| M8506
|
ML351 | ML351 | Lipoxygenase |
| ML351 is a cell penetrant, selective and highly potent human lipoxygenase-12/15 (15-Lipoxygenase-1, 12/15-LOX) inhibitor that exhibits protective effects against oxidative glutamate toxicity in mouse neuronal HT22 cells. | |||
| M8805 | Terameprocol | Terameprocol | Others |
| Terameprocol is a synthetic derivative of NDGA, a non-selective lipoxygenase inhibitor. | |||
| M9133
|
AKBA | 11-羰基-Β-乙酰乳香酸 | Lipoxygenase |
| 3-O-Acetyl-11-keto-β-boswellic acid; Acetyl-11-keto-β-boswellic acid | |||
| AKBA是一种从乳香中提取出的活性化合物，具有抗炎活性，能非竞争性地抑制5-脂氧合酶（Lipoxygenase），拓扑异构酶和白细胞弹性蛋白酶，还能活化Nrf2。AKBA在咪喹莫特诱导的银屑病小鼠模型中，能抑制MAT2A的活性。 | |||
| M10499
|
FPL 62064 | FPL 62064 | Lipoxygenase |
| FPL62064 | |||
| FPL 62064 是一种有效的 5-lipoxygenase (5-LOX) 和 prostaglandin synthetase (cyclooxygenase, COX) 的双重抑制剂，它对RBL-1 胞质 5-脂氧合酶和前列腺素合成酶prostaglandin synthetase的IC50值分别为3.5 μM和3.1 μM。 | |||
| M11119
|
11-Keto-beta-boswellic acid | 11-酮基-BETA-乳香酸 | Lipoxygenase |
| 11-Keto-β-boswellic acid | |||
| 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) 是一种五环三萜酸，来自俗称印度乳香 (Indian Frankincense) 的乳香树 (Boswellia serrate) 树皮的油树脂。 11-Keto-beta-boswellic acid 具有抗炎活性，主要是由于抑制 5-脂氧合酶 (5-lipoxygenase; 5-LOX)，白三烯 (leukotriene)，NF-κB的激活和肿瘤坏死因子 α 的产生。 | |||
| M15061
|
Atuliflapon | Atuliflapon | Lipoxygenase |
| AZD5718 | |||
| Atuliflapon (AZD5718) 是一款5-LOX激活蛋白（5 -脂氧合酶激活蛋白，FLAP）抑制剂，可减弱5-Lipoxygenase途径的活性并减少促炎性和血管活性白三烯（LT）的产生，体外半数最大抑制浓度 (IC50 ) 为 39nM。 | |||
| M19155
|
Entadamide A | 榼藤酰胺A | Lipoxygenase |
| Entadamide A is a natural product found in Entada rheedei and Entada gigas. Entadamide A inhibited the 5-lipoxygenase activity of RBL-1 cells at 10(-4) g/ml. | |||
| M20500 | Phenidone | Phenidone | COX |
| 1-phenyl-3-pyrazolidinone | |||
| Phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer. | |||
| M29823 | Masoprocol | 马索罗酚 | Lipoxygenase |
| meso-Nordihydroguaiaretic acid; meso-NDGA | |||
| Masoprocol (马索罗酚) 是一种有效的，具有口服活性的脂氧合酶 (lipoxygenase) 抑制剂以及Nrf2通路激活剂，能降低体内葡萄糖浓度和肝脏甘油三酯浓度，具有抗高血糖活性可用于II型糖尿病的相关研究。 | |||
| M42482 | h15-LOX-2 inhibitor 1 | h15-LOX-2 inhibitor 1 | Lipoxygenase |
| h15-LOX-2 inhibitor 1 是一种人上皮细胞 15-lipoxygenase-2 (h15-LOX-2) 抑制剂，其 IC50 值为 0.34 μM。 | |||
| M42487 | 5-LOX-IN-3 | 5-LOX-IN-3 | Lipoxygenase |
| 5-LOX-IN-3 是一种 5-Lipoxygenase 抑制剂 (IC50: <1 μM)。 | |||
| M56345 | Eicosatetraynoic acid | Eicosatetraynoic acid | COX |
| ETYA | |||
| Eicosatetraynoic acid (ETYA) 是 cyclooxygenase 和 lipoxygenase 的非特异性抑制剂 (ID50=8 μM 和 4 μM)。Eicosatetraynoic acid (ETYA) 10 μM 激活 PPARα 和 PPARγ 嵌合体。 | |||
| M56389 | (E)-KME-4 | (E)-KME-4 | PGE synthase |
| (E)-KME-4是有效的前列腺素合成酶 (prostaglandin synthetase) 抑制剂，IC50 值为0.28 μM；也可抑制5-脂肪氧合酶 (5-lipoxygenase) 的活性，IC50 值为 1.05 μM。 | |||
| M56710 | Aureusidin | Aureusidin | Lipoxygenase |
| Aureusidin 是一种黄酮类化合物，具有抗氧化（antioxidant）和抑制脂氧合酶（lipoxygenase）活性。Aureusidin 也具有抗炎活性。 | |||
| M56711 | 5-LOX-IN-1 | 5-LOX-IN-1 | Lipoxygenase |
| 5-LOX-IN-1 是 5-Lipoxygenase (5-LOX) 的抑制剂，IC50 值为 2.3 μM。5-LOX-IN-1 可用于癌症的研究。 | |||
