找到约 7 条 “Cholesterol-d7” 相关结果 （用时 0.105 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
| M22127 | Cholesterol-d7 | Cholesterol-d7 | Others |
| Cholesterol-d7 | |||
M6474
|
AY 9944 | AY 9944 | Others |
| AY 9944 dihydrochloride | |||
| AY 9944 是一种特异的胆固醇生物合成 (cholesterol biosynthesis) 抑制剂。AY 9944 抑制 7- 脱氢胆固醇 Δ7- 还原酶 (DHCR7) 酶，其 IC50 值为 13 nM。 | |||
| M15098
|
Recombinant Human PCSK9 (HEK293,C-6His) | 重组人PCSK9 蛋白 (HEK293,C-6His) | Cytokines and Growth Factors |
| Proprotein Convertase Subtilisin/Kexin Type 9 | |||
| Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. Accession #: Q8NBP7. | |||
| M18414
|
7-Dehydrocholesterol | 7-去氢胆固醇；7-脱氢胆固醇 | Ferroptosis |
| 7-DHC | |||
| 7-Dehydrocholesterol（7-DHC，7-去氢胆固醇）是一种胆固醇合成过程中的代谢中间体，同时也是不饱和甾醇，其甾醇B环上的共轭双键可以使7-DHC吸收自由基，从而抵消自由基触发脂质氧化和铁死亡的能力。 | |||
| M28685 | Cholesterol 24-hydroxylase-IN-1 | Cholesterol 24-hydroxylase-IN-1 | Cytochrome P450 (e.g. CYP17) |
| Cholesterol 24-hydroxylase-IN-1 (compound 17) 是一种强效、口服活性和高选择性的胆固醇24-羟化酶 (CH24H or CYP46A1) 抑制剂 (IC50=8.5 nM)。Cholesterol 24-hydroxylase-IN-1 能透过血脑屏障。 | |||
| M30042 | Cholesterol 5beta,6beta-epoxide | Cholesterol 5beta,6beta-epoxide | Others |
| Cholesterol beta-epoxide | |||
| Cholesterol 5beta,6beta-epoxide 是胆固醇的一种氧化代谢物，通过胆固醇在 5,6 双键处的自由基和非自由基氧化形成。在巨噬细胞分化的 U937 细胞中诱导乳酸脱氢酶 (LDH) 的释放和细胞凋亡。 | |||
| M30428 | 7α,25-Dihydroxycholesterol | 7α,25-Dihydroxycholesterol | GPR/FFAR |
| 7α, 25-dihydroxycholesterol (7α,25-OHC) 是一种孤儿 GPCR 受体 EBI2 (GPR183) 的有效选择性激动剂和内源性配体。7α, 25-dihydroxycholesterol 对激活 EBI2 有很强的作用 (EC50=140 pM; Kd=450 pM)。7α, 25-dihydroxycholesterol 可作为一种趋化因子，指导 B 细胞、T 细胞和树突状细胞的迁移。 | |||
