Streptomycin sulfate 硫酸链霉素

生物活性

Streptomycin Sulfate is the sulfate salt form of streptomycin, an aminoglycoside antibiotic derived from Streptomyces griseus with antibacterial property. Streptomycin sulfate binds to the S12 protein of the bacterial 30S ribosomal subunit, thereby inhibiting peptide elongation and protein synthesis, consequently leading to bacterial cell death. Streptomycin sulfate is a sulfate salt of streptomycin that is a protein synthesis inhibitor.

使用AbMole产品发表的文献

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产品使用成果展示

	数据来源	Pharmaceuticals 2020 Mar. Figure 1. Streptomycin (Abmole Bioscience, USA)
	方法	Vitro Antiproliferative Assays
	细胞系/动物模型	HepG2
	浓度	-
	处理时间	48 h
	实验结果	At a fixed concentration of 100 g/mL, EL-MeOH and fractions from E. lanceolatus displayed antiproliferative activity depending on studied cells.

化学性质

分子量	581.57
分子式	C21H39N7O12
CAS号	3810-74-0
溶解性（25°C）	Water 86 mg/mL
储存条件	-20°C, protect from light, sealed
运输方式	冰袋运输，根据产品的不同，可能会有相应调整。

储备液配制

*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前，需考虑其在不同溶剂中的溶解度限制。

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.7195 mL	8.5974 mL	17.1948 mL
5 mM	0.3439 mL	1.7195 mL	3.439 mL
10 mM	0.1719 mL	0.8597 mL	1.7195 mL

不同实验动物依据体表面积的等效剂量转换表（参考来源于公开文献）

	小鼠	大鼠	兔	豚鼠	仓鼠	狗
重量 (kg)	0.02	0.15	1.8	0.4	0.08	10
体表面积 (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km 系数	3	6	12	8	5	20

动物 A (mg/kg) = 动物 B (mg/kg) ×	动物 B的Km系数
	动物 A的Km系数

例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的K_m系数（3），再除以大鼠的K_m系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。

参考文献

[1] Sharma D,et.al. J Mol Biol Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome.