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Recombinant Rat CXCL2/CINC-2 Protein (E. coli) 重组大鼠CXCL2/CINC-2蛋白 (E. coli)

目录号 M22458 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


CXCL2/CINC-2,又称巨噬细胞炎症蛋白2(MIP-2)、生长调节蛋白β(Gro-beta)和Gro-2,属于CXC 趋化因子家族。CXCL2/MIP-2 在赋予耐受性的 APC 中被选择性上调,并用于将 NKT 细胞募集到脾脏边缘区,在那里它们与 APC 和 T 细胞形成簇。

Recombinant Rat CXCL2/CINC-2 Protein (E. coli)结构式

别名:GROb; Gro2; MIP-2

规格 价格 库存状态
20ug ¥ 3330 中国库存现货
其他规格数量报价?

质量标准及产品资料
生物活性

CXCL2/CINC-2,又称巨噬细胞炎症蛋白2(MIP-2)、生长调节蛋白β(Gro-beta)和Gro-2,属于CXC 趋化因子家族。CXCL2/MIP-2 在赋予耐受性的 APC 中被选择性上调,并用于将 NKT 细胞募集到脾脏边缘区,在那里它们与 APC 和 T 细胞形成簇。在没有 CXCL2/MIP-2 的高亲和力受体或存在 CXCL2/MIP-2 阻断抗体的情况下,外周耐受性被阻止,并且不会产生 Ag 特异性 T 调节细胞。研究表明 CXCL2 趋化因子在脓毒症的发展中起中介作用。CXCL2/MIP-2 在介导啮齿动物肺部对石英、青石棉石棉等颗粒以及高剂量其他相对无害粉尘(如二氧化钛)的中性粒细胞炎症反应中也起着重要作用。


编码大鼠 Cxcl2 (NP_446099.1) (Ser32-Asn100) 的 DNA 序列在 N 末端用两个额外的氨基酸 (Gly & Pro) 表达。

重组大鼠 Cxcl2 由 69 个氨基酸组成,预测分子量为 7.6 kDa。

剂型描述:从无菌 20 mM Tris、500 mM NaCl、pH 8 中冻干。

化学性质
储存条件 Stable for up to twelve months from date of receipt at -20℃ to -80℃
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] F Shibata, et al. Cytokine. Identification of a common receptor for three types of rat cytokine-induced neutrophil chemoattractants (CINCs)

[2] F Shibata, et al. Cytokine. Differential changes in the concentrations of cytokine-induced neutrophil chemoattractant (CINC)-1 and CINC-2 in exudate during rat lipopolysaccharide-induced inflammation

[3] F Shibata, et al. Eur J Biochem. Recombinant production and biological properties of rat cytokine-induced neutrophil chemoattractants, GRO/CINC-2 alpha, CINC-2 beta and CINC-3

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