CXCL2/CINC-2,又称巨噬细胞炎症蛋白2(MIP-2)、生长调节蛋白β(Gro-beta)和Gro-2,属于CXC 趋化因子家族。CXCL2/MIP-2 在赋予耐受性的 APC 中被选择性上调,并用于将 NKT 细胞募集到脾脏边缘区,在那里它们与 APC 和 T 细胞形成簇。
别名:GROb; Gro2; MIP-2
CXCL2/CINC-2,又称巨噬细胞炎症蛋白2(MIP-2)、生长调节蛋白β(Gro-beta)和Gro-2,属于CXC 趋化因子家族。CXCL2/MIP-2 在赋予耐受性的 APC 中被选择性上调,并用于将 NKT 细胞募集到脾脏边缘区,在那里它们与 APC 和 T 细胞形成簇。在没有 CXCL2/MIP-2 的高亲和力受体或存在 CXCL2/MIP-2 阻断抗体的情况下,外周耐受性被阻止,并且不会产生 Ag 特异性 T 调节细胞。研究表明 CXCL2 趋化因子在脓毒症的发展中起中介作用。CXCL2/MIP-2 在介导啮齿动物肺部对石英、青石棉石棉等颗粒以及高剂量其他相对无害粉尘(如二氧化钛)的中性粒细胞炎症反应中也起着重要作用。
编码大鼠 Cxcl2 (NP_446099.1) (Ser32-Asn100) 的 DNA 序列在 N 末端用两个额外的氨基酸 (Gly & Pro) 表达。
重组大鼠 Cxcl2 由 69 个氨基酸组成,预测分子量为 7.6 kDa。
剂型描述:从无菌 20 mM Tris、500 mM NaCl、pH 8 中冻干。
储存条件 | Stable for up to twelve months from date of receipt at -20℃ to -80℃ |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
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