基质细胞衍生因子-1α / CXCL12 (SDF-1α)和SDF-1β是趋化因子α亚家族成员，缺乏ELR结构域，最初使用信号序列陷阱克隆策略从小鼠骨髓基质细胞系中鉴定。蛋白构造：SDF-1α/CXCL12 (Lys22-Lys89)，Accession #： Q4FJL5。
别名：SDF-1-α; SDF1α; CXCL-12; IRH
种属：Mouse
表达系统：E. coli
纯度：SDS-PAGE分析> 97%，高效液相色谱分析> 97%
内毒素：LAL法测定蛋白质含量< 1 EU/μg
理论分子量：8 kDa
存储及稳定性：在接收后，该产品在-70°C或-20°C下保持稳定长达6个月。重组后，产品应在4°C下稳定1周或在-20°C下稳定3个月。避免反复的冻融循环。
生物活性：与标准相比完全具有生物活性。使用人外周血单核细胞的趋化性生物测定法测定的生物活性在50.0-100.0 ng/ml的浓度范围内。SDF-1α和SDF-1β cdna分别编码89和93个氨基酸残基的前体蛋白。SDF-1α和SDF-1β均由单一基因编码，并通过交替剪接产生。这两种蛋白除了SDF-1β羧基端存在四个氨基酸残基而SDF-1α缺失外，其余均相同。SDF-1/PBSF在物种间高度保守，成熟的人和小鼠蛋白之间只有一个氨基酸替换。SDF-1/PBSF通过趋化因子受体CXCR4起作用，已被证明是t淋巴细胞、单核细胞、前B细胞和前B细胞的趋化剂，但不是中性粒细胞。研究发现，缺乏SDF-1或CXCR4的小鼠在中枢神经系统中会受损b淋巴细胞生成、骨髓生成、血管发育、心脏发生以及异常的神经细胞迁移和模式。
| 溶解性（25°C） | Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. |
| 储存条件 |
Stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
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蛋白质研究