重组小鼠RANK 由哺乳动物表达系统产生，编码 Val31-Ser214 的靶基因在 C 端用 6His 标签表达。RANK与其配体RANKL结合后，可通过TRAF蛋白磷酸化激活NF-κB、JNK、ERK、p38、Akt/PKB等信号通路。
别名：Receptor activator of NF-KB; NFKB activator
重组小鼠RANK 由哺乳动物表达系统产生，编码 Val31-Ser214 的靶基因在 C 端用 6His 标签表达。RANK与其配体RANKL结合后，可通过TRAF蛋白磷酸化激活NF-κB、JNK、ERK、p38、Akt/PKB等信号通路。Receptor activator of NF-κB(RANK,TNFRSF11A)属于肿瘤坏死因子受体家族的一员，是TNFSF11/RANKL/TRANCE/OPGL的受体。RANK在小梁骨、胸腺、小肠、肺、脑和肾中普遍高表达，但在脾脏和骨髓中微弱表达。RANK/TNFRSF11A 信号在很大程度上被认为是促进生长和减少细胞凋亡，例如在破骨细胞中观察到的作用。
蛋白编号：O35305
表观分子量：26-30 KDa，还原条件
剂型描述：从 0.2 μm 过滤的 PBS 溶液中冻干，pH 7.4。
| 溶解性（25°C） | Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| 储存条件 | Stored at ≤ -20°C, stable for one year after receipt |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
[3] Jingxuan Yang, et al. Methods Mol Biol. Osteoclast Differentiation Assay
[4] Emilia Mia Sordillo, et al. Cancer. RANK-Fc: a therapeutic antagonist for RANK-L in myeloma
| 其他相关的Recombinant Proteins产品 |
|---|
| Recombinant Mouse Lumican (Mammalian, C-6His)
Lumican binds to laminin. It has positive regulation of transcription from RNA polymerase II promoter and transforming growth factor beta1 production. |
| Recombinant Human Serpin A12 (E.coli, N-GST)
Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. |
| Recombinant Human B2M Protein (Mammalian, C-6His)
β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. |
| Recombinant Mouse E-Selectin/CD62E Protein (HEK293)
E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involved in cancer cell metastasis. |
| Recombinant Human DPP4/CD26 (Mammalian, C-6His)
DPP4/CD26 is a signal-anchor for type II membrane protein that belongs to the peptidase S9B family. DPP4/CD26 acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. It’s binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. |
产品仅供科学研究或药证申报的用途使用，不为任何个人或者非科研性质的其他用途提供服务。
Copyright © 2010-2022 AbMole版权所有 沪ICP备16047849号 沪公网安备 31011502012228号
蛋白质研究