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Recombinant Mouse HSP70 Protein (HEK293, His Tag) 重组小鼠Hsp70蛋白(HEK293, His Tag)

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HSPA1A 是 Hsp70 蛋白家族的成员。Hsp70s 是广泛表达的热休克蛋白家族。Hsp70 家族稳定先前存在的蛋白质以防止聚集,并介导细胞质和细胞器内新翻译的多肽的折叠。

Recombinant Mouse HSP70 Protein (HEK293, His Tag)结构式

别名:HSPA1A; heat shock 70kDa protein 1A

规格 价格 库存状态
100ug ¥ 5742 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >95%, Endotoxin < 1 EU/μg
  • COA
  • MSDS
生物活性

HSPA1A 是 Hsp70 蛋白家族的成员。Hsp70s 是广泛表达的热休克蛋白家族。Hsp70 家族稳定先前存在的蛋白质以防止聚集,并介导细胞质和细胞器内新翻译的多肽的折叠。HSP 是存在于所有细胞中的丰富且保守的蛋白质。在温度冲击或其他应激刺激下,HSP 在细胞内合成,可保护细胞免于蛋白质变性或死亡。在细胞外,HSP 可以发挥细胞因子功能,通过激活 APC 启动先天免疫和适应性免疫。HSP 还具有伴侣功能并有助于将抗原肽呈递给 T 细胞。Hsp70 家族的分子伴侣在细胞中具有多种功能。它们协助折叠新合成的和应激变性的蛋白质,以及将蛋白质导入细胞器,和聚集蛋白的解离。 

重组小鼠 HSP70 由 651 个氨基酸组成,预测分子量为 71.5 kDa。它在还原条件下在 SDS-PAGE 中以约 64.3 kDa 的条带迁移。 

编码小鼠 HSP70 (NP_034609.2) (Ala2-Asp641) 的 DNA 序列在 N 末端用多组氨酸标签表达。 

剂型描述:从无菌 PBS 中冻干,pH 7.4。

化学性质
溶解性(25°C) Reconstitute the lyophilized powder in ddH2O or PBS at 100 μg/mL
储存条件 Stable for up to twelve months from date of receipt at -20℃ to -80℃
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] S Demyanenko, et al. Cell Stress Chaperones. Exogenous recombinant Hsp70 mediates neuroprotection after photothrombotic stroke

[2] Vasily Golotin, et al. Biomolecules. Recombinant Fusion Protein Joining E Protein Domain III of Tick-Borne Encephalitis Virus and HSP70 of Yersinia pseudotuberculosis as an Antigen for the TI-Complexes

[3] Stefan Stangl, et al. Radiother Oncol. Detection of irradiation-induced, membrane heat shock protein 70 (Hsp70) in mouse tumors using Hsp70 Fab fragment

[4] Gabriele Multhoff, et al. Cell Stress Chaperones. Distinguishing integral and receptor-bound heat shock protein 70 (Hsp70) on the cell surface by Hsp70-specific antibodies

[5] Seiji Takemoto, et al. Pharm Res. Pharmacokinetic and tissue distribution mechanism of mouse recombinant heat shock protein 70 in mice

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