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Recombinant Mouse Beta-NGF Protein (110AA, E. coli) 重组小鼠β-NGF蛋白 (110AA, E. coli)

目录号 M11232 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. β-NGF acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival.

Recombinant Mouse Beta-NGF Protein (110AA, E. coli)结构式

别名:β-NGF; NGFB

规格 价格 库存状态
10ug ¥ 1125 中国库存现货
50ug ¥ 2250 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >95%, Endotoxin <1 EU/μg
  • COA
  • MSDS
生物活性

Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. β-NGF acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. It is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems.

Measured by the cell proliferation assay using TF‑1 human erythroleukemic cells, the ED50 for this effect is 68.52 ng/ml.


Accession: P01139

APMol Mass: 13 KDa, reducing conditions

Endotoxin < 1 EU/µg

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, pH 8.0.

化学性质
性状 Lyophilized powder
溶解性(25°C) Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml.
储存条件 Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at ≤ -20°C for 3 months.
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Kevin O Rivera, et al. Sci Rep. Local injections of β-NGF accelerates endochondral fracture repair by promoting cartilage to bone conversion

[2] Caroline Pinet-Charvet, et al. Sci Rep. Beta-nerve growth factor stimulates spontaneous electrical activity of in vitro embryonic mouse GnRH neurons through a P75 mediated-mechanism

[3] Jun Yuan, et al. Mol Cell Biochem. Overexpression of β-NGF promotes differentiation of bone marrow mesenchymal stem cells into neurons through regulation of AKT and MAPK pathway

[4] G Heinrich, et al. Biochem Biophys Res Commun. Nerve growth factor (NGF) is present in human placenta and semen, but undetectable in normal and Paget's disease blood: measurements with an anti-mouse-NGF enzyme immunoassay using a recombinant human NGF reference

[5] L A Cunningham, et al. Exp Neurol. Survival and differentiation within the adult mouse striatum of grafted rat pheochromocytoma cells (PC12) genetically modified to express recombinant beta-NGF

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